Morphological, Release and Antibacterial Performances of Amoxicillin-Loaded Cellulose Aerogels

Abstract

Cellulose has been widely used in the biomedical field. In this study, novel cellulose aerogels were firstly prepared in a NaOH-based solvent system by a facile casting method. Then amoxicillin was successfully loaded into cellulose aerogels with different loadings. The morphology and structure of the cellulose aerogels were characterized using scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). The drug release and antibacterial activities were also evaluated. The drug release results showed that cellulose aerogels have controlled amoxicillin release performance. In vitro antibacterial assay demonstrated that the cellulose aerogels exhibited excellent antibacterial activity with the amoxicillin dose-dependent activity. Therefore, the developed cellulose aerogels display controlled release behavior and efficient antibacterial performance, thus confirming their potential for biomedical applications.

Antibacterial Activity of Bacterial Cellulose Loaded with Bacitracin and Amoxicillin: In Vitro Studies

“…In this step, the water is removed. The retained water quantity is in agreement with other reports for BC [ 32 ] but is in general lower for the BC when compared with normal cellulose (~50%) [ 21 ].…”

“…This very porous structure is important and can explain some properties of BC, namely the high-water uptake, ability to absorb the exudates and toxins, but also to adsorb and release the biological active agents. It is very important to mention that the morphology is totally different compared with the cellulose aerogels’ morphology loaded or not with amoxicillin, as reported by Ye et al [ 21 ], as the bacterial cellulose fibrillar structure is not characteristic even if, in both cases, the porosity is very high.…”

“…The bacterial cellulose membranes’ functionality was demonstrated by evaluating the antibacterial effect on Escherichia coli and Staphylococcus aureus . Currently, amoxicillin has been loaded in cellulose aerogel (cellulose of vegetal origin) [ 21 ], but no paper has reported the bacitracin loading in cellulose and especially in bacterial cellulose.…”

A Review on Revolutionary Natural Biopolymer-Based Aerogels for Antibacterial Delivery

“…However, due to many reasons, including the use of minimal or less inhibitory concentrations, many bacteria have developed resistance to this antibiotic. Shan et al [ 103 ] loaded amoxicillin in cellulose aerogel with the aim of getting the better performance of the antibiotic when it is directly applied to the infected area. The loaded aerogels exhibited excellent antibacterial activity with prolonged release of the antibiotic.…”

Antibacterial cellulose-based aerogels for wound healing application: A review

“…The high capacity of aerogels to absorb water lends support to their potential use in wound dressing. Shan et al 67 have loaded Amoxicillin antibiotic inside of cellulose aerogel, aiming for better performance after they controlled amoxicillin release. The antibiotic lost its effect against many types of bacteria due to the misuse of it; most of the bacteria had already developed resistance to this antibiotic.…”