Synthesis of Antibacterial Gelatin/Sodium Alginate Sponges and Their Antibacterial Activity

Wen, Yanyi; Yu, Bing; Zhu, Zhongjie; Yang, Zhuoran; Shao, Wei

doi:10.3390/polym12091926

Cited by 23 publications

(7 citation statements)

References 31 publications

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“…However, the main disadvantages of gelatin are its low thermal stability and insufficient mechanical properties. Gelatin is used, inter alia , as a dressing material, in the production of soft and hard capsules, drug delivery systems, and in tissue engineering [ 50 , 51 , 52 , 53 , 54 , 55 ].…”

Section: Biopolymers Used To Prepare Hydrogelsmentioning

confidence: 99%

Are Natural Compounds a Promising Alternative to Synthetic Cross-Linking Agents in the Preparation of Hydrogels?

2023

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The main aim of this review is to assess the potential use of natural cross-linking agents, such as genipin, citric acid, tannic acid, epigallocatechin gallate, and vanillin in preparing chemically cross-linked hydrogels for the biomedical, pharmaceutical, and cosmetic industries. Chemical cross-linking is one of the most important methods that is commonly used to form mechanically strong hydrogels based on biopolymers, such as alginates, chitosan, hyaluronic acid, collagen, gelatin, and fibroin. Moreover, the properties of natural cross-linking agents and their advantages and disadvantages are compared relative to their commonly known synthetic cross-linking counterparts. Nowadays, advanced technologies can facilitate the acquisition of high-purity biomaterials from unreacted components with no additional purification steps. However, while planning and designing a chemical process, energy and water consumption should be limited in order to reduce the risks associated with global warming. However, many synthetic cross-linking agents, such as N,N’-methylenebisacrylamide, ethylene glycol dimethacrylate, poly (ethylene glycol) diacrylates, epichlorohydrin, and glutaraldehyde, are harmful to both humans and the environment. One solution to this problem could be the use of bio-cross-linking agents obtained from natural resources, which would eliminate their toxic effects and ensure the safety for humans and the environment.

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Section: Biopolymers Used To Prepare Hydrogelsmentioning

confidence: 99%

Are Natural Compounds a Promising Alternative to Synthetic Cross-Linking Agents in the Preparation of Hydrogels?

2023

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“…The bands around 1025 cm − 1 are the C-O-C bonds as identi ed in sodium alginate as well 34 . Furthermore, the peak at about 1415-1460 cm − 1 is attributed to COO-, which is linked to the alginate hydrogen 35 . The peak at 1526 cm − 1 is due to the N-H group of amide II and that observed at 1266 cm − 1 is associated with the N-H group of amide III of gelatin 35,36 .…”

Section: Rna Extraction and Real Time-pcrmentioning

confidence: 99%

“…Furthermore, the peak at about 1415-1460 cm − 1 is attributed to COO-, which is linked to the alginate hydrogen 35 . The peak at 1526 cm − 1 is due to the N-H group of amide II and that observed at 1266 cm − 1 is associated with the N-H group of amide III of gelatin 35,36 . The peak appeared at 1625 cm − 1 is the characteristic of-CONH 2 group, indicating that the negative group of alginate is probably linked with positive load of gelatin 37 .…”

Section: Rna Extraction and Real Time-pcrmentioning

confidence: 99%

Development of a hydrogel-based three Dimensional (3D) Glioblastoma Cell lines Culture as a Model System for CD73 inhibitor response study

Bahraminasab

Asgharzade

Doostmohamadi

et al. 2023

Preprint

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Despite the development of various therapeutic approaches over the past decades, the glioblastoma (GBM) treatment remains a major challenge. The extracellular adenosine-generating enzyme CD73 is involved in the pathogenesis and progression of GBM, and targeting CD73 may represent a novel approach to this cancer. This study characterized three-dimensional culture systems based on three compositions of hydrogel and chose an optimum type for local delivery of CD73 to target GBM cells as a possible therapeutic approach for this disease. Rheology measurements, Fourier Transform Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy (SEM), and cell proliferation assay were conducted to analyze the synthesized hydrogel and choose an optimal formula. The viability of tumor cells in the optimal hydrogel was assessed by histology and confocal microscopy imaging. Furthermore, tumor cells' sensitivity to CD73 inhibitor was investigated by cell proliferation assay and real-time PCR. The data demonstrated that the hydrogel with 5 w% gelatin and 5 w% sodium alginate had superior rheological properties and cell viability. Therefore, it could provide a more suitable environment for GBM cells and mimic the natural microenvironment more properly. CD73 inhibitor-treated GBM cells significantly decreased proliferation rate and expressions of VEGF and HIF1-α within the optimal hydrogel. Our current research revealed the great potential of CD73 inhibitor for clinical translation of cancer study by analyzing 3D tumor cell behavior and function, and therefore for more effective treatment protocols for GBM.

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“…The in vitro studies showed that the TCH-loaded sponges exhibited a controlled release profile with good antibacterial efficacy against E. coli ATCC25, ATCC922, as well as B. subtilis ATCC 9372 and S. aureus ATCC 6538. The fabricated gelatin-sodium alginate sponges are potential wound dressings for treating bacteria-infected wounds [ 73 ].…”

Section: Gelatin-based Hybrid Wound Dressingsmentioning

confidence: 99%

Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings

et al. 2021

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Wound care is a major biomedical field that is challenging due to the delayed wound healing process. Some factors are responsible for delayed wound healing such as malnutrition, poor oxygen flow, smoking, diseases (such as diabetes and cancer), microbial infections, etc. The currently used wound dressings suffer from various limitations, including poor antimicrobial activity, etc. Wound dressings that are formulated from biopolymers (e.g., cellulose, chitin, gelatin, chitosan, etc.) demonstrate interesting properties, such as good biocompatibility, non-toxicity, biodegradability, and attractive antimicrobial activity. Although biopolymer-based wound dressings display the aforementioned excellent features, they possess poor mechanical properties. Gelatin, a biopolymer has excellent biocompatibility, hemostatic property, reduced cytotoxicity, low antigenicity, and promotes cellular attachment and growth. However, it suffers from poor mechanical properties and antimicrobial activity. It is crosslinked with other polymers to enhance its mechanical properties. Furthermore, the incorporation of antimicrobial agents into gelatin-based wound dressings enhance their antimicrobial activity in vitro and in vivo. This review is focused on the development of hybrid wound dressings from a combination of gelatin and other polymers with good biological, mechanical, and physicochemical features which are appropriate for ideal wound dressings. Gelatin-based wound dressings are promising scaffolds for the treatment of infected, exuding, and bleeding wounds. This review article reports gelatin-based wound dressings which were developed between 2016 and 2021.

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Synthesis of Antibacterial Gelatin/Sodium Alginate Sponges and Their Antibacterial Activity

Cited by 23 publications

References 31 publications

Are Natural Compounds a Promising Alternative to Synthetic Cross-Linking Agents in the Preparation of Hydrogels?

Are Natural Compounds a Promising Alternative to Synthetic Cross-Linking Agents in the Preparation of Hydrogels?

Development of a hydrogel-based three Dimensional (3D) Glioblastoma Cell lines Culture as a Model System for CD73 inhibitor response study

Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings

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