“…Similarly, higher levels of plasma lactate are associated with incident T2DM (31) and could modify calcium fractions (28). Lastly, it is worth noting that adjustment for albumin concentration has been proposed for another biomarker associated with incident T2DM (fructosamine) (32,33), although it is still unclear the appropriateness of such adjustment given (34). Interestingly, our results are in line with a previous study showing no difference in direct iCa measurement comparing subjects with and without diabetes (11); notably, the Authors speculated that 'correction' of total calcium for serum albumin would not be appropriate because of an increased serum free fatty acids concentrations.…”