Association between direct measurement of active serum calcium and risk of type 2 diabetes mellitus: A prospective study

Zaccardi, Francesco; Webb, David R.; Carter, Patrice; Pitocco, Dario; Davies, Melanie J.; Kurl, Sudhir; Laukkanen, Jari A.

doi:10.1016/j.numecd.2015.02.013

Cited by 9 publications

(15 citation statements)

References 33 publications

(41 reference statements)

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“…In addition, significant differences were observed across all quartiles of serum calcium concentration in terms of female ratio, alcohol drinking ratio, the ratio of diabetes, and the ratio of hypertension. These findings were in accordance with some previous studies that indicated that serum calcium levels are associated with alcohol drinking, 31 , 32 sex difference, 33 , 34 diabetes, 35 , 36 and hypertension, 37 , 38 and need future studies to elaborate further.…”

Section: Discussionsupporting

confidence: 93%

Serum Calcium Concentration Is Inversely Associated With Radiographic Knee Osteoarthritis

Zeng

Wei

et al. 2016

Medicine

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To examine the relationship between serum calcium (Ca) concentration and radiographic knee osteoarthritis (OA).This study covered a total of 2855 subjects. The serum Ca concentration was detected by the Arsenazo III method. The radiographic OA of the knee was defined as changes equivalent to Kellgren–Lawrence grade 2 on 1 side at least. The serum Ca concentration was categorized into 4 quartiles, which are ≤2.27, 2.28–2.34, 2.35–2.41, and ≥2.42 mmol/L, respectively. The relationship between serum Ca and radiographic knee OA was examined using the multivariable logistic analysis after adjusting a series of potential confounding factors. For each quartile of the relationship between serum Ca concentration and radiographic knee OA, the OR with 95% CI was calculated, and the one with the lowest value was considered to be the reference.An inverse association existed between serum Ca concentration and radiographic OA of the knee in the multivariable model and the model where the factors of age, sex, and BMI were adjusted. The multivariable-adjusted OR (95% CI) for radiographic knee OA in the second, third, and fourth quartiles of serum Ca concentration were 1.05 (95% CI: 0.83–1.31), 1.01 (95% CI: 0.80–1.27), and 0.79 (95% CI: 0.62–1.00), respectively, in comparison with the reference (first) quartile. A trend approaching to statistical significant (P = 0.06) was observed. Meanwhile, the relative odds of radiographic OA of the knee were decreased by 0.79 times in the fourth quartile in comparison with the reference.There is likely to be an inverse association between serum Ca concentration and radiographic OA of the knee.

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Section: Discussionsupporting

confidence: 93%

Serum Calcium Concentration Is Inversely Associated With Radiographic Knee Osteoarthritis

Zeng

Wei

et al. 2016

Medicine

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“…Recently, limited number of studies have reported that higher serum calcium levels are associated with an increased risk of T2D development [ 2 – 5 ]. However, the association between serum calcium levels and T2D development was not observed in another epidemiological study [ 6 ]. In addition, the positive associations between serum calcium levels and T2D were unexpected, considering that higher calcium intake has been associated with lower T2D risk [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 92%

Associations of serum calcium levels and dietary calcium intake with incident type 2 diabetes over 10 years: the Korean Genome and Epidemiology Study (KoGES)

Kim

Hong

2018

Diabetol Metab Syndr

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BackgroundPrevious evidence regarding the associations between serum calcium concentrations, dietary calcium intake, and type 2 diabetes (T2D) is limited. We investigated the longitudinal associations of serum calcium levels and dietary calcium intake with T2D development.MethodsThis study used data from the Ansung–Ansan cohort, a community-based, prospective cohort that was followed up for 10 years. Cox regression models adjusted for potential confounders were used to evaluate the associations of serum calcium levels (mean, 9.41 mg/dL) and dietary calcium intake (median, 389.59 mg/day) with T2D incidence. Association between dietary calcium intake and serum calcium levels was assessed using linear regression models.ResultsAlbumin-adjusted serum calcium levels were not associated with T2D risk (hazard ratio [HR] = 1.07, 95% confidence interval [CI] 0.96, 1.19, p-value = 0.2333). A one-unit increase in log-transformed, energy-adjusted dietary calcium intake was associated with a decreased risk of T2D (HR = 0.88, 95% CI 0.77, 1.00, p-value = 0.0460) and lower albumin-adjusted serum calcium levels (β = − 0.04, 95% CI − 0.07, − 0.02, p-value = 0.0014). The associations did not differ according to sex (all p-values for interaction > 0.10).ConclusionsSerum calcium levels were not associated with T2D risk, while higher dietary calcium intake was associated with a decreased risk of T2D development. These results have public health implications for predicting and preventing T2D development, as well as providing guidelines for diet and calcium supplementation.

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“…Ca, an essential mineral, exerts a wide range of biological functions, including bone and tooth mineralisation, blood coagulation, muscle contraction, nerve impulse transmission and cellular signalling transduction (4,6–9) . Additionally, Ca plays a pivotal role in insulin secretion and glucose homeostasis (4,10,11) . Glucose-dependent insulin secretion is a Ca-regulated process, which depends on intracellular Ca concentration in pancreatic β -cells (10,12) .…”

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confidence: 99%

“…Additionally, Ca plays a pivotal role in insulin secretion and glucose homeostasis (4,10,11) . Glucose-dependent insulin secretion is a Ca-regulated process, which depends on intracellular Ca concentration in pancreatic β -cells (10,12) . Moreover, increased cytosolic Ca also affects glucose uptake in the myocyte (10,13,14) .…”

mentioning

confidence: 99%

“…Glucose-dependent insulin secretion is a Ca-regulated process, which depends on intracellular Ca concentration in pancreatic β -cells (10,12) . Moreover, increased cytosolic Ca also affects glucose uptake in the myocyte (10,13,14) . Consequently, abnormal Ca homeostasis could potentially be involved with defects in insulin action and disorders in glucose homeostasis, contributing to T2DM development (4,10,11,15,16) .…”

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confidence: 99%

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Circulating calcium levels and the risk of type 2 diabetes: a systematic review and meta-analysis

et al. 2019

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Abnormal Ca homeostasis has been associated with impaired glucose metabolism. However, the epidemiological evidence is controversial. We aimed to assess the association between circulating Ca levels and the risk of type 2 diabetes mellitus (T2DM) or abnormal glucose homeostasis through conducting a systematic review and meta-analysis. Eligible studies were identified by searching electronic database (PubMed, Embase and Google Scholar) and related references with de novo results from primary studies up to December 2018. A random-effects meta-analysis was performed to estimate the weighted relative risks (RR) and 95 % CI for the associations. The search yielded twenty eligible publications with eight cohort studies identified for the meta-analysis, which included a total of 89 165 participants. Comparing the highest with the lowest category of albumin-adjusted serum Ca, the pooled RR was 1·14 (95 % CI 1·05, 1·24) for T2DM (n 51 489). Similarly, serum total Ca was associated with incident T2DM (RR 1·25; 95 % CI 1·10, 1·42) (n 64 502). Additionally, the adjusted RR for 1 mg/dl increments in albumin-adjusted serum Ca or serum total Ca levels was 1·16 (95 % CI 1·07, 1·27) and 1·19 (95 % CI 1·11, 1·28), respectively. The observed associations remained with the inclusion of a cohort study with ionised Ca as the exposure. However, data pooled from neither case–control (n 4) nor cross-sectional (n 8) studies manifested a significant correlation between circulating Ca and glucose homeostasis. In conclusion, accumulated data from the cohort studies suggest that higher circulating Ca levels are associated with an augmented risk of T2DM.

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Association between direct measurement of active serum calcium and risk of type 2 diabetes mellitus: A prospective study

Cited by 9 publications

References 33 publications

Serum Calcium Concentration Is Inversely Associated With Radiographic Knee Osteoarthritis

Serum Calcium Concentration Is Inversely Associated With Radiographic Knee Osteoarthritis

Associations of serum calcium levels and dietary calcium intake with incident type 2 diabetes over 10 years: the Korean Genome and Epidemiology Study (KoGES)

Circulating calcium levels and the risk of type 2 diabetes: a systematic review and meta-analysis

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