Consensus statement on the worldwide standardisation of the HbA1c measurement

Hicks, Jocelyn M.; Müller, Markus; Panteghini, Mauro; John, Garry; Deeb, Larry C.; Buse, John B.; Nathan, David M.; Kahn, Richard; Ferrannini, Eleuterio; Heine, Robert J.; Silink, Martin; Mbanya, Jean Claude

doi:10.1007/s00125-007-0789-7

Cited by 106 publications

(18 citation statements)

References 13 publications

(9 reference statements)

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“…A possible reason for this is unavailability or scarcity of this test in Nigeria at this time. While daily blood glucose monitoring tells how blood sugar is doing at a specific point in time (allowing necessary changes in medicine, food, and exercise), the HbA1c test show an individual’s glucose control and thus risk of complications [17]. It also identifies changes in response to alterations in management and therefore gives a picture of long term diabetes management success [17].…”

Section: Discussionmentioning

confidence: 99%

“…While daily blood glucose monitoring tells how blood sugar is doing at a specific point in time (allowing necessary changes in medicine, food, and exercise), the HbA1c test show an individual’s glucose control and thus risk of complications [17]. It also identifies changes in response to alterations in management and therefore gives a picture of long term diabetes management success [17]. The result in the present study would therefore portray that a majority of Nigerian diabetics are unaware of their risk of developing complications, and in the dark in terms of the long term management of their condition.…”

Section: Discussionmentioning

confidence: 99%

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Determinants of diabetes knowledge in a cohort of Nigerian diabetics

Jasper

Ogundunmade

Opara

et al. 2014

J Diabetes Metab Disord

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BackgroundOne of the consequences of the generational paradigm shift of lifestyle from the traditional African model to a more "western" standard is a replacement of communicable diseases by non-communicable or life style related diseases like diabetes. To address this trend, diabetes education along with continuous assessment of diabetes related knowledge has been advocated. Since most of the Nigerian studies assessing knowledge of diabetes were hospital-based, we decided to evaluate the diabetes related knowledge and its sociodemographic determinants in a general population of diabetics.MethodsDiabetics (n = 184) attending the 2012 world diabetes day celebration in a Nigerian community were surveyed using a two part questionnaire. Section A elicited information on their demographics characteristics and participation in update courses, and exercise, while section B assessed knowledge of diabetes using the 14 item Michigan Diabetes Research and Training Centre's Brief Diabetes Knowledge Test.ResultsWe found that Nigerian diabetics had poor knowledge of diabetes, with pervasive fallacies. Majority did not have knowledge of "diabetes diet", "fatty food", "free food", effect of unsweetened fruit juice on blood glucose, treatment of hypoglycaemia, and the average duration glycosylated haemoglobin (haemoglobin A1) test measures blood glucose. Attaining tertiary education, falling under the 51-60 years age group, frequent attendance at seminars/updates and satisfaction with education received, being employed by or formerly working for the government, and claiming an intermediate, or wealthy income status was associated with better knowledge of diabetes.ConclusionNigerian diabetics' knowledge of diabetes was poor and related to age, level of education, satisfaction with education received, employment status and household wealth.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Determinants of diabetes knowledge in a cohort of Nigerian diabetics

Jasper

Ogundunmade

Opara

et al. 2014

J Diabetes Metab Disord

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“…Assays for HbA1c concentrations, which reflect average plasma glucose across the past 120 days, were performed on a Tosoh A1C G7. HbA1c values were converted to the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) standardized units (25). …”

Section: Methodsmentioning

confidence: 99%

Prolonged Nightly Fasting and Breast Cancer Risk: Findings from NHANES (2009–2010)

Marinac

Sears

Gallo

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background A novel line of research has emerged suggesting that daily feeding-fasting schedules that are synchronized with sleep-wake cycles have metabolic implications that are highly relevant to breast cancer. We examined associations of nighttime fasting duration with biomarkers of breast cancer risk among women in the 2009-2010 U.S. National Health and Nutrition Examination Survey. Methods Dietary, anthropometric and HbA1c data were available for 2,212 women, and 2-hour postprandial glucose concentrations were available for 1,066 women. Nighttime fasting duration was calculated using 24-hour food records. Separate linear regression models examined associations of nighttime fasting with HbA1c and 2-hour glucose concentrations. Logistic regression modeled associations of nighttime fasting with elevated HbA1c (HbA1c ≥ 39 mmol/mol or 5.7%) and elevated 2-hour glucose (glucose ≥ 140 mg/dL). All models adjusted for age, education, race/ethnicity, BMI, total kcal intake, evening kcal intake, and the number of eating episodes per day. Results Each 3-hour increase in nighttime fasting (roughly one standard deviation) was associated with a 4% lower 2-hour glucose measurement (β 0.96, 95% CI 0.93-1.00; p<0.05), and a non-statistically significant decrease in HbA1c. Logistic regression models indicate that each 3-hour increase in nighttime fasting duration was associated with roughly a 20% reduced odds of elevated HbA1c (OR 0.81, 95% CI 0.68, 0.97; p<0.05) and non-significantly reduced odds of elevated 2-hour glucose. Conclusions A longer nighttime duration was significantly associated with improved glycemic regulation. Impact Randomized trials are needed to confirm whether prolonged nighttime fasting could improve biomarkers of glucose control, thereby reducing breast cancer risk.

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“…The HbA1c values are reported as the percent of total hemoglobin that is glycosylated as well as the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) reference method which reports it as mmol/mol (ADA et al. 2007 ).…”

Section: Methodsmentioning

confidence: 99%

Gastric electrical stimulation treatment of type 2 diabetes: effects of implantation versus meal-mediated stimulation. A randomized blinded cross-over trial

Ludvik

Kozakowski

Tarnowski³

et al. 2015

Physiol Rep

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Gastric electrical stimulation with the implanted DIAMOND device has been shown to improve glycemic control and decrease weight and systolic blood pressure in patients with type 2 diabetes inadequately controlled with oral antidiabetic agents. The objective of this study was to determine if device implantation alone (placebo effect) contributes to the long-term metabolic benefits of DIAMOND® meal-mediated gastric electrical stimulation in patients with type 2 diabetes. The study was a 48 week randomized, blinded, cross-over trial in university centers comparing glycemic improvement of DIAMOND® implanted patients with type 2 diabetic with no activation of the electrical stimulation (placebo) versus meal-mediated activation of the electrical signal. The endpoint was improvement in glycemic control (HbA1c) from baseline to 24 and 48 weeks. In period 1 (0–24 weeks), equal improvement in HbA1c occurred independent of whether the meal-mediated electrical stimulation was turned on or left off (HbA1c −0.80% and −0.85% [−8.8 and −9.0 mmol/mol]). The device placebo improvement proved to be transient as it was lost in period 2 (25–48 weeks). With electrical stimulation turned off, HbA1c returned toward baseline values (8.06 compared to 8.32%; 64.2 to 67.4 mmol/mol, P = 0.465). In contrast, turning the electrical stimulation on in period 2 sustained the decrease in HbA1c from baseline (−0.93%, −10.1mmol/mol, P = 0.001) observed in period 1. The results indicate that implantation of the DIAMOND device causes a transient improvement in HbA1c which is not sustained beyond 24 weeks. Meal-mediated electrical stimulation accounts for the significant improvement in HbA1c beyond 24 weeks.

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Consensus statement on the worldwide standardisation of the HbA1c measurement

Cited by 106 publications

References 13 publications

Determinants of diabetes knowledge in a cohort of Nigerian diabetics

Determinants of diabetes knowledge in a cohort of Nigerian diabetics

Prolonged Nightly Fasting and Breast Cancer Risk: Findings from NHANES (2009–2010)

Gastric electrical stimulation treatment of type 2 diabetes: effects of implantation versus meal-mediated stimulation. A randomized blinded cross-over trial

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