Testosterone and Estradiol among Older Men

Orwoll, Eric; Lambert, Lori; Marshall, Lynn M.; Phipps, Kathy R.; Blank, Janet Babich; Barrett‐Connor, Elizabeth; Cauley, Jane A.; Ensrud, Kristine E.; Cummings, Steve

doi:10.1210/jc.2005-1830

Cited by 286 publications

(202 citation statements)

References 50 publications

Supporting

Mentioning

177

Contrasting

Unclassified

Order By: Relevance

“…On average, intra-and inter-assay coefficients of variation were: 4.1% and 5.5% (total testosterone), 5.4% and 8.2% (total estradiol), 6.3% and 8.6% (estrone), 3.9% and 7.5% (androstenedione), respectively. These coefficients were comparable with indicators of intra-and inter-assay variation in other large-scale population studies that used RIA assays to measure sex steroids in men (17)(18)(19).…”

Section: Biochemical Analysissupporting

confidence: 75%

“…Each assay was highly specific -the crossreactivity of a measured hormone with other sex steroids was minimal (generally below 1.0%). Consistent with the previous studies that examined estradiol concentrations in male population (14,17) we used an ultra-sensitive RIA designed specifically to measure estradiol in men and children. The sensitivity of other assays was also sufficient to measure circulating concentrations of sex steroids in men.…”

Section: Biochemical Analysismentioning

confidence: 99%

See 1 more Smart Citation

Association between lipid profile and circulating concentrations of estrogens in young men

et al. 2009

View full text Add to dashboard Cite

Objectives-Men show higher rates of cardiovascular morbidity and mortality than premenopausal women and this sexual dimorphism may be related to sex-specific effects of sex steroids on cardiovascular risk factors. Unlike androgens, estrogens were not extensively investigated in relation to cardiovascular phenotypes in men.Methods-We examined associations of estradiol and estrone and their precursors (total testosterone and androstenedione) with traditional cardiovascular risk factors (lipids, blood pressure, body mass) in 933 young (median age -19 years), apparently healthy Polish men.Results-Total estradiol was associated with total cholesterol (p=0.006) and HDL-cholesterol (p<0.001) and estrone showed the strongest associations with both total cholesterol (p<0.001) and LDL-cholesterol (p<0.001) in the unadjusted ANOVA analysis. In the multivariable adjusted models in which other independent variables were held as constant one standard deviation increase in estradiol level was associated with 6%-standard deviation increase in total cholesterol (standardized B=0.06, p=0.038) and 6%-standard deviation decrease in p=0.036). An increase in estrone levels by one standard deviation was associated with respective 12%-and 13%-standard deviation increases in total cholesterol (standardized B=0.12, p<0.001) and LDL-cholesterol levels (standardized B=0.12, p<0.001) after controlling for other predictors of lipids. Estrone correlated linearly with androstenedione (r=0.28, p<0.001) but there was no correlation between estradiol and testosterone. Estrogens retained their independent associations with lipids after adjustment for their biochemical precursors in the multivariable analysis.Conclusions-Increased levels of estrogens are associated with unfavourable lipid profile in men and that this association is apparent early in life, before cardiovascular disease manifestations.

show abstract

Section: Biochemical Analysissupporting

confidence: 75%

Section: Biochemical Analysismentioning

confidence: 99%

Association between lipid profile and circulating concentrations of estrogens in young men

et al. 2009

View full text Add to dashboard Cite

show abstract

“…11 In older men above the age of 65 or 70 years, the changes in total testosterone are overshadowed by more significant declines in free testosterone levels. 13,14 The observation that in a cross-sectional analysis of 3638 men aged 70 years and above total testosterone levels were stable whereas free testosterone levels declined with increasing age 14 is supported by a study describing comparable total testosterone levels in groups of men aged 18.9 vs 75.4 years. 15 At constant total testosterone, increased SHBG by providing more binding sites for testosterone would be expected to reduce the fraction of free testosterone and SHBG levels rise with increasing age.…”

Section: Testosterone Levels Decline As Men Grow Oldermentioning

confidence: 95%

“…[16][17][18] Thus, even though total testosterone and SHBG remain correlated in older men, the age-related increase in SHBG could modulate levels of free testosterone in a setting where total testosterone is relatively preserved. 13,14 However, multiple mechanisms are likely to influence the decline in testosterone levels in aging men. 19 Lower testosterone levels may result from reduced testicular responses to LH with aging coupled with incomplete hypothalamo-pituitary compensation for the fall in total and free testosterone levels.…”

Section: Testosterone Levels Decline As Men Grow Oldermentioning

confidence: 99%

“…80,81,97,99 Thus, lower testosterone levels are associated with higher body mass index (BMI), and with increased prevalence and incidence of metabolic syndrome and Type II diabetes in middle-aged and older men. 10,11,13,14,19,[100][101][102][103][104][105][106][107] In addition, lower testosterone levels are associated with surrogate markers for cardiovascular disease, including less favorable carotid intima medial thickness, 108-110 ankle/brachial index as a measure of peripheral arterial disease 111 and calcific aortic atheroma. 112 Thus, Low testosterone levels and ill-health in aging men BB Yeap lower testosterone levels, erectile dysfunction and conditions associated with higher cardiovascular risk appear to be interrelated.…”

Section: Testosterone Cardiovascular Risk and Mortality In Aging Menmentioning

confidence: 99%

See 1 more Smart Citation

Are declining testosterone levels a major risk factor for ill-health in aging men?

Yeap

2008

Int J Impot Res

View full text Add to dashboard Cite

As men grow older, testosterone levels fall, with a steeper decline in unbound or free testosterone compared with total testosterone concentrations. Lower testosterone levels have been associated with poorer cognitive function, and with impaired general and sexual health in aging men. Recently, lower testosterone levels have been linked with metabolic syndrome and type II diabetes, both conditions associated with cardiovascular disease, and shown to predict higher overall and cardiovascular-related mortality in middle-aged and older men. However, reverse causation has to be considered, as systemic illness may result in reduced testosterone levels. Thus, the strength of these associations and the likely direction of causation need to be carefully considered. Furthermore, these conditions may overlap, for example aging, lower testosterone levels, erectile dysfunction and cardiovascular disease are interrelated. Cross-sectional and longitudinal observational studies may be informative. However, ultimately randomized controlled trials of testosterone therapy are needed to clarify its role in the maintenance of general and sexual health in aging men. Testosterone therapy should be considered in hypogonadal men who meet rigorous criteria for the diagnosis of androgen deficiency. Additional consideration should be given to designing and testing interventions that may prevent or ameliorate the age-related decline in testosterone levels in men.

show abstract

Low Free Testosterone Concentration as a Potentially Treatable Cause of Depressive Symptoms in Older Men

Almeida¹,

Yeap²,

Hankey³

et al. 2008

Arch Gen Psychiatry

137

View full text Add to dashboard Cite

A free testosterone concentration in the lowest quintile is associated with a higher prevalence of depression, and this association cannot be adequately explained by physical comorbidity. A randomized controlled trial is required to determine whether the link between low free testosterone level and depression is causal because older men with depression may benefit from systematic screening of free testosterone concentration and testosterone supplementation.

show abstract

Testosterone and Estradiol among Older Men

Cited by 286 publications

References 50 publications

Association between lipid profile and circulating concentrations of estrogens in young men

Association between lipid profile and circulating concentrations of estrogens in young men

Are declining testosterone levels a major risk factor for ill-health in aging men?

Low Free Testosterone Concentration as a Potentially Treatable Cause of Depressive Symptoms in Older Men

Contact Info

Product

Resources

About