Association between lipid profile and circulating concentrations of estrogens in young men

Tomaszewski, Maciej; Charchar, Fadi J.; Maric, Christine; Kuźniewicz, Roman; Gola, Mateusz; Grzeszczak, W; Samani, Nilesh J.; Żukowska-Szczechowska, E

doi:10.1016/j.atherosclerosis.2008.06.002

Cited by 29 publications

(17 citation statements)

References 34 publications

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“…Additionally, males may be more sensitive to the cardiovascular effects of estrogens. Higher levels of estradiol levels have been associated with an increased risk of stroke, (39) severity of coronary artery disease (40) and elevated total cholesterol (41) lending credence to the hypothesis that males respond differently to estrogens compared to females. Furthermore, the association of elevated levels of estradiol with diseases of the cardiovascular system in men suggest that men may have more severe endothelial dysfunction in response to estradiol compared to females.…”

Section: Discussionmentioning

confidence: 93%

Postoperative Estradiol Levels Associate With Development of Primary Graft Dysfunction in Lung Transplantation Patients

et al. 2012

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Primary graft dysfunction (PGD) frequently complicates lung transplantation in the immediate postoperative period. Both female gender and estradiol modulate the body’s response to injury and may influence the rate of alveolar fluid clearance. We hypothesized that female gender and higher estradiol levels would be associated with a lower risk of PGD after lung transplantation. We measured plasma estradiol levels pre-operatively, 6 hours postoperatively and 24 hours postoperatively in a cohort of 111 lung transplant recipients at two institutions. The mean age was 57 years (+/− 12.5) and 52% were female. The median postoperative estradiol level was 63.9 pg/ml (IQR 28.8–154.3) in men and 65.1 pg/ml (IQR 28.4–217.2) in females. Contrary to our hypothesis, higher estradiol levels at 24 hours were associated with an increased risk of PGD at 72 hours in males (p=0.001). This association was preserved when accounting for other factors known to be associated with PGD. However, there was no relationship between gender and risk of PGD or between estradiol levels and PGD in females. These findings suggest that there may be different biologic effects of estrogens in males and females and highlight the importance of considering gender differences in future studies of PGD.

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Section: Discussionmentioning

confidence: 93%

Postoperative Estradiol Levels Associate With Development of Primary Graft Dysfunction in Lung Transplantation Patients

et al. 2012

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“…16,17 In the present study decreased HDL levels were observed which are non-significantly negatively correlated with estrodial this finding was similar with the other studies. 18…”

Section: Discussionmentioning

confidence: 99%

Estradiol and lipid levels in men with acute myocardial infarction

et al. 2020

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Background: The incidence of myocardial infarction (MI) is more common in men when compared with women and women after menopause are at high risk of MI. This gender difference in CVD risk might be because of the difference in the circulating estrogen levels in men and women. Dyslipidemia is also one of the major causes of MI. The present study was aimed to estimate the levels of serum estradiol and serum lipids in newly diagnosed male MI cases and to find out any correlation between these two.Methods: The study was conducted on 50 newly diagnosed MI admitted in Cardiology department Narayana general hospital and Medical College, Nellore. Only males were included in the study. Fifty age and sex-matched healthy individuals were selected as controls. Lipid levels are estimated by endpoint colorimetric assay (HUMANSTAR kit) and estradiol was estimated by Chemiluminance immune assay (CLIA).Results: Significantly raised levels of estradiol (p-value <0.0001) and low HDL cholesterol (p-value =0.0085) levels were noticed among the cases compared to controls. No significant correlation was observed between estradiol and lipoproteins (HDL and LDL).Conclusions: The results of the present study in acute MI compared to controls show hyper estrogenemia in Male MI cases, which may be the underlying cause for thrombosis in acute MI. Decreased levels of HDL cholesterol are observed in the MI cases which are known to increase the risk of Atherosclerosis. No significant correlation were noticed between Estradiol and HDL cholesterol in men with acute MI.

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“…Similarly, a study of 809 adult men in the USA 25 reveals that testosterone levels negatively associate with CRP; yet total and free E2 positively associate with CRP and white blood cell levels. Several studies repeatedly report that increased E2 levels in middle-age men indicate worse cardiovascular risk phenotype such as atherogenic lipid profile 25 , coronary artery disease 26 , and increased carotid artery intima-media thickness 27 . Hence, the present study suggests that there is a continuum in the association of E2 with cardiovascular risk and low grade inflammation in men, starting from childhood to adulthood.…”

Section: Discussionmentioning

confidence: 99%

Free estradiol index levels associated with high sensitivity CRP levels in male children

2017

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Ağırbaşlı M, Tanrıkulu A, Azizy M. Free estradiol index levels associated with high sensitivitiy CRP levels in male children. Turk J Pediatr 2017; 59: 49-55. Biomarkers of inflammation such as high-sensitivity C-reactive protein (hs-CRP) associate with subclinical atherosclerosis. Atherosclerosis is an early onset disease in life. Sex hormones and puberty modulate metabolism in children. Studies indicate that low sex hormone binding globulin (SHBG) levels associate with insulin resistance and metabolic syndrome in children. The aim of this study is to study the correlation between sex hormones and hs-CRP levels in children and adolescents. The study sample was derived from a cross sectional survey on the prevalence of cardiovascular risk factors in a representative sample of school children (8-17 year-old) in Istanbul, Turkey. In addition to anthropometric and biochemical characteristics of cardiovascular risk, sex hormones such as free androgen index, free estradiol index (FEI), SHBG and hs-CRP levels were measured in all study participants: 91 boys (12.4 ± 3.4 years) and 77 girls (12.7 ± 3.4 years) were included in the study. Median (interquartile range) hs-CRP levels were similar among boys and girls [0.36 (0.9) versus 0.45 (0.7) mg/dl, p= 0.725]. Gender stratified analysis displayed that hs-CRP levels positively correlated with FEI levels (r=0.438, p < 0.001) in boys. Linear regression analysis was performed to determine the predictors of hs-CRP. Among covariates of FEI, homeostasis model assessment-estimated insulin resistance, body mass index, age, and SHBG; FEI was shown to significantly and independently predict hs-CRP levels in boys [β=2.758, p < 0.001, 95% confidence interval (CI) for β 1.471-4.045]. FEI levels associate with subclinical inflammation in boys. Future studies may elucidate the role of sex hormone levels in inflammation among children.

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Association between lipid profile and circulating concentrations of estrogens in young men

Cited by 29 publications

References 34 publications

Postoperative Estradiol Levels Associate With Development of Primary Graft Dysfunction in Lung Transplantation Patients

Postoperative Estradiol Levels Associate With Development of Primary Graft Dysfunction in Lung Transplantation Patients

Estradiol and lipid levels in men with acute myocardial infarction

Free estradiol index levels associated with high sensitivity CRP levels in male children

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