Testosterone and coronary heart disease: is there a link?

English, K; Steeds, RP; Jones, T. Hugh; Channer, KS

doi:10.1093/qjmed/90.12.787

Cited by 55 publications

(32 citation statements)

References 39 publications

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“…This is reported to result from the unfavourable effects of the male sex hormone, testosterone (3). However, numerous clinical and epidemiological studies reported a controversial relationship between testosterone and cardiovascular disease.…”

Section: Introductionmentioning

confidence: 99%

Testosterone Relaxes Isolated Human Radial Artery by Potassium Channel Opening Action

et al. 2007

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Abstract. Preliminary clinical studies of testosterone therapy in male patients with coronary artery disease obtained promising results. However, little is known about the in vitro effects of testosterone in human isolated arteries. We investigated the effect of testosterone on contractile tone of human isolated radial artery (RA). Testosterone was added (0.1 -300 µM ) cumulatively to organ baths after precontraction with KCl (45 mM) and phenylephrine (PE, 10 µM). Testosterone-induced relaxations were tested in the presence of the cyclooxygenase inhibitor indomethacin (10 µM), nitric oxide synthase inhibitor N ω -nitro-L-arginine methyl ester (L-NAME, 100 µM), non-selective large conductance Ca

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Section: Introductionmentioning

confidence: 99%

Testosterone Relaxes Isolated Human Radial Artery by Potassium Channel Opening Action

et al. 2007

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“…In men, levels of testosterone fall with increasing age (9,10) and it is in the elderly population that the highest rates of CHD are found. Low plasma testosterone levels in men are associated with known risk factors for CHD including age, hypertension, obesity, raised fibrinogen, hyperinsulinaemia, diabetes mellitus and adverse lipid profile (11). Males with CHD have lower serum levels of bioavailable testosterone than men of a similar age with normal coronary angiograms (12).…”

Section: Introductionmentioning

confidence: 99%

Testosterone does not adversely affect fibrinogen or tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) levels in 46 men with chronic stable angina

et al. 2005

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Objective: In women, sex hormones cause increased morbidity and mortality in patients with coronary heart disease (CHD) and adversely affect the coagulation profile. We have studied the effect of physiological testosterone replacement therapy in men on coagulation factor expression, to determine if there is an increased risk of thrombosis. Methods: Double-blind, randomized, placebo-controlled trial of testosterone in 46 men with chronic stable angina. Measurements of free, total and bioavailable testosterone, luteinising hormone (LH) and follicle-stimulating hormone (FSH), estradiol, plasminogen activator inhibitor-1 (PAI-1), fibrinogen, tissue plasminogen activator (tPA) and full blood count were made at 0, 6 and 14 weeks.

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“…Indeed, hypotestosteronaemia is associated with numerous risk factors for CAD including hypertension, hyperinsulinaemia, diabetes, obesity, age and adverse thrombotic profile (reviewed in ref. 9), and testosterone levels have been reported to be inversely proportional to atherosclerotic risk (10 -14). Recent work by our group has demonstrated that men with significant CAD (greater than 75% stenosis on angiography) have significantly lower levels of bioavailable testosterone than a group of age-and weight-matched men with normal coronary arteries (15).…”

Section: Introductionmentioning

confidence: 99%

Altered circulating hormone levels, endothelial function and vascular reactivity in the testicular feminised mouse

Jones

Pugh²,

Hall³

et al. 2003

European Journal of Endocrinology

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Objective: Testicular feminised (Tfm) mice express a non-functional androgen receptor, and also have reduced levels of circulating testosterone. Recent studies support a cardio-protective role for testosterone since it elicits systemic and pulmonary vasodilatation. The aim of the present study was to determine whether androgen insensitivity and hypotestosteronaemia in the Tfm mouse are associated with abnormal vascular reactivity or hormone status. Methods: Adult male Tfm and littermate control mice were killed and the blood collected. Femoral (diameter range = 183 -508 mm) and pulmonary (diameter range = 320-816 mm) arteries were dissected and loaded in either a wire or pressure myograph, at 100 mmHg or 17.5 mmHg respectively. Pharmacological assessment of the vasoreactivity to potassium chloride (KCl, 80 mmol/l) and either noradrenaline (NA, 1 nmol/l -100 mmol/l) and acetylcholine (ACh, 0.1 -100 mmol/l) or testosterone (1 nmol/l -100 mmol/l) was then made. Results: Tfm mice had reduced levels of testosterone (1.8^0.3 nmol/l) compared with controls (9.3^2.0 nmol/l, P , 0:001Þ and elevated levels of cholesterol (3.6+0.1 mmol/l) compared with controls ð3:2 þ 0:1 mmol=l; P , 0:05Þ: Femoral arteries from Tfm mice exhibited reduced vasoconstriction to 80 mmol/l KCl ð3:27^0:23 mN=mmÞ compared with vessels from controls ð4:44^0:41 mN=mm; P , 0:05Þ; and reduced endothelial-dependent vasodilatation to 0.1-100 mmol/l ACh ð23:3^3:6% relaxation) compared with vessels from controls ð41:6^5:4% relaxation, P , 0:05Þ: Vasoconstriction to NA (1 nmol/l -100 mmol/l) and vasodilatation to testosterone were unaffected. Conclusions: Androgen receptor deficiency and hypotestosteronaemia in the Tfm mouse reduced endothelial function and impaired voltage-operated calcium channel activity, which may pre-dispose to cardiovascular disease. Testosterone-induced vasodilatation was unaffected, demonstrating no involvement of the androgen receptor in this response.

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Testosterone and coronary heart disease: is there a link?

Cited by 55 publications

References 39 publications

Testosterone Relaxes Isolated Human Radial Artery by Potassium Channel Opening Action

Testosterone Relaxes Isolated Human Radial Artery by Potassium Channel Opening Action

Testosterone does not adversely affect fibrinogen or tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) levels in 46 men with chronic stable angina

Altered circulating hormone levels, endothelial function and vascular reactivity in the testicular feminised mouse

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