tert-Butyl nitrite catalyzed synthesis of benzimidazoles from o-phenylenediamine and aldehydes at room temperature

Ionic‐Liquid‐Catalyzed Synthesis of Imines, Benzimidazoles, Benzothiazoles, Quinoxalines and Quinolines through C−N, C−S, and C−C Bond Formation

“…2‐(4‐ tert ‐Butylyphenyl)‐1H‐benzoimidazole (7 i) [26] Yield (216 mg, 86 % yield, white solid), m.p. 248 – 250 °C.…”

Development of bioactive 2-substituted benzimidazole derivatives using an MnOx/HT nanocomposite catalyst

“…Benzimidazole and its derivatives have showcased a variety of therapeutical applications such as anticancer, anti-inflammatory, antihypertensive, antifungal, and antiviral activities. [1][2][3][4][5][6][7][8][9][10][11] They also have potent biological significance against some viruses such as herpes (HSV-1), influenza, and HIV due to their unique fused ring structure, imidazole ring, and benzene ring. 12,13 The acidic and salt-forming abilities of benzimidazole are also the reason for its biological activeness.…”

Sunlight‐Assisted Photocatalytic Sustainable Synthesis of 1,4‐Disubstituted 1,2,3‐Triazoles and Benzimidazoles Using TiO2−Cu2(OH)PO4 Under Solvent‐Free Condition

“…[27][28][29] In general, benzimidazoles are synthesized by the reaction of o-phenylenediamines with carbonyl compounds in the presence of different homogeneous and heterogeneous catalytic systems. [30][31][32][33] Even though the synthesis of 1,4-disubstituted 1,2,3triazoles and benzimidazoles are proficiently performed in conventional (heating) reaction condition, product stability and reduction in the yields are the prime disadvantageous of those methods. Thus, there is an increasing claim for green synthesis using sustainable catalytic conditions.…”

“…Moreover, based on optical properties of benzimidazoles based materials, they can be also used as dyes, energy storage device, chemosensors and LED applications [27–29] . In general, benzimidazoles are synthesized by the reaction of o‐phenylenediamines with carbonyl compounds in the presence of different homogeneous and heterogeneous catalytic systems [30–33] …”