The water‐mediated, metal‐free, 2,2,6,6‐tetramethylpiperidine‐1‐oxyl (TEMPO) promoted oxidative [3+2] cycloaddition of organic azides with electron‐deficient terminal and internal olefins was explored. A library of 1,4‐disubstituted and 1,4,5‐trisubstituted‐1,2,3‐triazoles were synthesized in moderate to excellent yields. This method was also found to be compatible not only with open‐chain olefins but also with cyclic olefins.
Herein, we report the facile synthesis of 1,4‐disubstituted 1,2,3‐triazoles and benzimidazoles using TiO2−Cu2(OH)PO4 as an efficient sunlight active nanophotocatalyst under solvent‐free condition. The highlights of the proposed protocol are simple, scalable with a broad substrate scope, short reaction time, excellent regioselectivity and catalyst recyclability. The use of recyclable photocatalyst and solvent‐free condition makes the catalytic system resulted in sustainable and environmental‐friendly procedure.
Oxidative [3 + 2] cycloaddition of activated olefins and azides is reported with readily available CuO nanoparticles. 1,4-Disubsitituted and 1,4,5-trisubstituted 1,2,3-triazoles have been achieved without use of base or additives in a shorter time.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.