A practical synthesis of isoxazole/isoxazoline
derivatives via
Machetti–De Sarlo reaction under sustainable conditions has
been accomplished. This protocol involves the use of readily available
2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) to catalyze
the cyclocondensation of primary nitroalkanes with alkynes/alkenes
to afford a library of isoxazole/isoxazoline products. From an eco-benign
perspective, notable advantages of this method are as follows: (i)
water as the solvent, (ii) air as the oxidant, (iii) transition metal-free,
(iv) no base required, (v) no toxic byproduct, (vi) no need of solvent
extraction, (vii) diverse substrate scope, (viii) high chemical yields,
(ix) excellent chemo- and regioselectivity, (x) short reaction time,
(xi) gram-scale synthesis, (xii) extension to heterogeneous version,
and (xiii) catalyst recyclability. For these reasons, the developed
method is appropriate for safe laboratory use and can be expected
to inspire the progress of TEMPO-based organocatalysis for the preparation
of isoxazole/isoxazoline moieties in an environmentally benign fashion.
Herein, we report the facile synthesis of 1,4‐disubstituted 1,2,3‐triazoles and benzimidazoles using TiO2−Cu2(OH)PO4 as an efficient sunlight active nanophotocatalyst under solvent‐free condition. The highlights of the proposed protocol are simple, scalable with a broad substrate scope, short reaction time, excellent regioselectivity and catalyst recyclability. The use of recyclable photocatalyst and solvent‐free condition makes the catalytic system resulted in sustainable and environmental‐friendly procedure.
Herein, we designed and synthesizeda series of 1,2,3‐triazole tethered 3‐hydroxy‐2‐oxindoles (4 a‐j) using N‐propargyl isatin derivatives as key starting materials (1 a‐d) under ball‐milling conditions by merging aldol condensation and click reaction. The synthesized compounds (4 a‐j) were examined for their corrosion inhibition behavior in mild steel using gravimetric and electrochemical analysis. The compound 4 i was identified as the most efficient compound with an efficiency of >70%. Also, the adsorption of inhibitors on the surface of mild steel and mixed type of behaviors was evidenced by impedance and Tafel polarization studies, respectively. Further, the evaluation of antibacterial and antifungal activities demonstrated that compound 4 gpossessed a significant potential to behave as an antimicrobial agent.
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