Terpenoid and biflavonoid constituents of Calophyllum calaba and Garcinia spicata from Sri Lanka

Endodesmiadiol, a Friedelane Triterpenoid, and Other Antiplasmodial Compounds from Endodesmia calophylloides

“…The location of the two hydroxy groups at C-2 and C-28 on the friedelane skeleton comes from correlations observed with the methine and methylene protons at d 3.78 (1H, t, Jϭ3.2 Hz) and 3.42 (2H, br s), respectively, on the HMBC spectrum of 1 (Table 1). This was further confirmed by the mass spectrum fragmentation pattern and by comparison of 13 C-NMR chemical shifts of 1 with those of canophyllol, 17) which shares with 1 identical BCDE ring moieties. The stereochemistry at C-2 was elucidated by the analysis of the ROESY NMR data.…”

“…These 1 H-and 13 C-NMR data suggested a triterpene skeleton for 1. The presence in the MS spectrum of 1 of characteristic fragments with m/z 317, 289, 203, 151 and 109 were in accord with a friedelane type triterpene, 23,24) with the carbonyl and one hydroxy group in the ring A or B and the second in the ring E. Higher plant triterpenoids being derived from oxidosqualene cyclization, 25,26) an oxygenated function has been assigned to C-3.…”

“…IR spectra were obtained with a Perkin-Elmer 881 Infrared spectrophotometer or a Nicolet Avatar 320 FT-IR with KBr discs and [a] D with a Perkin-Elmer 341 polarimeter. NMR spectra were recorded on a Bruker AC300 instrument equipped with a 5 mm 1 H and 13 C probe operating at 300 and 75 MHz respectively with CHCl 3 (dϭ7.26) and CDCl 3 (dϭ77.0) as internal standards. 2D experiments were performed using Bruker WP400 spectrometer.…”

Antifungal and antibacterial activities of different extracts ofHarungana madagascariensisstem bark

“…The family Clusiaceae is well known for the production of various phenolic compounds such as anthraquinones, xanthones, coumarins, biflavonoids, and anthrone derivatives (Gunatilaka et al, 1984;Iinuma et al, 1995;Ritchie & Taylor, 1964) which are known to exhibit antimicrobial activities (Kitanov & Blinova, 1987;Rabanal et al, 2002). The ability of the extracts of this plant to inhibit the growth of several bacteria and fungi is an indication of the broad-spectrum antimicrobial potential that further validates the use of this plant for the treatment of various ailments in Africa.…”

Chromanone Derivatives from the Pericarps of Calophyllum polyanthum

“…The UV data (l max 371, 314, 301, 277 nm) suggested the presence of a pyranochromanone moiety, which is common to chapelieric acid [11], isocalolongic acid [12], and other oxo-pyranochroman-carboxylic acids. The IR absorptions at ñ max 3433 and 1706 cm À1 indicated OH and CO groups, respectively.…”