Endodesmiadiol, a Friedelane Triterpenoid, and Other Antiplasmodial Compounds from Endodesmia calophylloides

Non-toxic melanin production inhibitors from Garcinia livingstonei (Clusiaceae)

“…The activity of morelloflavone (1) as an antiinflammatory (Gil et al, 1997;Castardo et al, 2008) and antioxidant (Sanz et al, 1994;Deachathai et al, 2005;Hutadilok-Towatana et al, 2007) are well-documented; it has also been found to be a potent tyrosinase inhibitor (Masuda et al, 2005), anti-HIV-1 (Lin et al, 1997), and anti-bacterial (Verdi et al, 2004) agent, and to have antimalarial (Ngouamegne et al, 2008) and analgesic (Luzzi et al, 1997) properties. Isojacareubin (5) is known for its activity as an anticoagulant (Wu et al, 1998), and 6-deoxyisojacareubin (6) for its antifungal (Morel et al, 2002) and antibacterial (Kuete et al, 2007) properties, while sargaol (4) shows marked activity as an antioxidant (Nahas et al, 2007).…”

Triterpenoids from Camellia japonica and Their Cytotoxic Activity

“…The known compounds were identified as 3a-hydroxy-1-oxo friedelan (1), 19) friedelin (2), 20,21) 3b-friedelanol (3), 21,22) canophyllol (4), 21,23) 3-oxo friedelan-1(2)-ene (5), 21) b-amyrin (9), 21) camellenodiol (10), 8) and camelledionol (11) C-NMR spectrum of 7 revealed 32 carbon signals, which were sorted by DEPT experiment as nine methyls, eight methylenes, six methines, and nine quaternary carbons, of which, two oxygenated methine, two olefinic and two carbonyl carbons were suggested on the basis of the chemical shifts. The above data suggested that compound 7 was an oleanane-type triterpene with the presence of an a,b-unsaturated carbonyl {d H 5.65, (1H, s, H-12), d C 128.3 (C-12), 168.5 (C-13) and 200.1 (C-11)} in the structure compared with that of 11-keto-b-amyrenyl acetate from Vellozia compacta.…”

Antimicrobial activity and phytochemical fingerprints of five crude extracts obtained from indigenous medicinal plants of Uganda

“…The presence of these compounds indicates that the examined extracts could be used as templates for the development of new antimalarial or antibiotic medicines. The biological function of these compounds against the plasmodium parasite has been reported (Dolabela et al, 2008;Ngouamegne et al, 2008;Murata et al, 2008;Likhiwitayawuid et al, 1997;Ramanandraibe et al, 2008;Ajaiyeoba et al, 2007).…”