Terpenes on Rhipicephalus (Boophilus) microplus: Acaricidal activity and acetylcholinesterase inhibition

Cardoso, Alana dos Santos; Santos, Everton Gomes Guimarães dos; Lima, Aldilene da Silva; Temeyer, Kevin B.; León, Adalberto A. Pérez de; Costa, Lívio Martins; Soares, Alexandra Martins dos Santos

doi:10.1016/j.vetpar.2020.109090

Cited by 46 publications

(18 citation statements)

References 42 publications

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“…Therefore, even if observing some time-dependent fractionation, the relative composition in terpenes of the different fractions is quite similar and, consequently, not significant differences in bioactivities could be expected. In this sense, as mentioned above, distinct biological activities have been associated to the presence of different families of terpenes [40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56], and therefore, a better separation of these terpenes is mandatory. Moreover, a different selectivity would make the identification of the different terpenes easier.…”

Section: Time-dependent Scco2 Fractionation Of Terpenes From Olive Leavesmentioning

confidence: 99%

Extraction and Mass Spectrometric Characterization of Terpenes Recovered from Olive Leaves Using a New Adsorbent-Assisted Supercritical CO2 Process

Montenegro

Álvarez‐Rivera

Mendiola

2021

Foods

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This work reports the use of GC-QTOF-MS to obtain a deep characterization of terpenoid compounds recovered from olive leaves, which is one of the largest by-products generated by the olive oil industry. This work includes an innovative supercritical CO2 fractionation process based on the online coupling of supercritical fluid extraction (SFE) and dynamic adsorption/desorption for the selective enrichment of terpenoids in the different olive leaves extracts. The selectivity of different commercial adsorbents such as silica gel, zeolite, and aluminum oxide was evaluated toward the different terpene families present in olive leaves. Operating at 30 MPa and 60 °C, an adsorbent-assisted fractionation was carried out every 20 min for a total time of 120 min. For the first time, GC-QTOF-MS allowed the identification of 40 terpenoids in olive leaves. The GC-QTOF-MS results indicate that silica gel is a suitable adsorbent to partially retain polyunsaturated C10 and C15 terpenes. In addition, aluminum oxide increases C20 recoveries, whereas crystalline zeolites favor C30 terpenes recoveries. The different healthy properties that have been described for terpenoids makes the current SFE-GC-QTOF-MS process especially interesting and suitable for their revalorization.

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Section: Time-dependent Scco2 Fractionation Of Terpenes From Olive Leavesmentioning

confidence: 99%

Extraction and Mass Spectrometric Characterization of Terpenes Recovered from Olive Leaves Using a New Adsorbent-Assisted Supercritical CO2 Process

Montenegro

Álvarez‐Rivera

Mendiola

2021

Foods

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“…We believe the behavioral features of ixodes play a significant role in the transmission of pathogens, in particular, the activity of ticks, their mobility and ability to seek and attack their prey and it depends on the effectiveness of transmission of pathogens of various etiologies. Later, Alana Dos Santos Cardoso and co-authors (Cardoso et al, 2020) showed the ability of thymol and carvacrol to inhibit one of the most important central nervous system enzymes acetylcholinesterase, which is similar to the action of classical acaricides, in particular propoxur. Also, thymol affects the reproductive function of females of Rhipicephalus sanguineus thereby suppressing their ability to reproduce (Matos et al, 2020).…”

Section: Discussionmentioning

confidence: 90%

The effectiveness of acaricidic drugs based on herbal raw material

Voronova

Horban

Bohatkina

2021

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Limitation the number of ixodes ticks is one of the most important tasks of modern science and requires the search for new, highly effective and environmentally hazardous acaricides, so our experiment was aimed at identifying acaricidal properties of essential oils and their individual active components in the population of ixodes ticks in Zaporizhzhia region. The study of acaricidal properties of essential oils was performed in the laboratory conditions. Tampons with wool were soaked in various concentrations of 0.5%, 1%, 3%, 5% and 10% aqueous emulsion of essential oils such as Caryophyllus floris aetheroleum and Limonis aetheroleum, and essential oils of Thymus serpyllum L., Рinus sylvestris L., Salvia officinalis L., Mentha x piperita L. and Eucalyptus viminalis Labill. The essential oils had a significant effect on the lifespan of adult ticks. The results showed the acaricidal effect of Thymus serpyllum essential oils. When searching the acaricidal and repellent properties of individual essential oils components thymole, menthol and citral showed the high activity as acaricides. In the same time, eugenol and borneol proved the effectiveness as repellent. Our research schowed that essential oils are promising as alternative methods of controlling the number of Ixodes ticks in areas where there are conditions for infection with tick infections.

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“…The pesticidal activity of this oil was associated with a high content of 1.8-cineole, also known as eucalyptol (Miresmailli et al, 2006;George et al, 2009). In a previous study with R. microplus, eucalyptol showed greater AChE inhibition against the resistant strain (IC 50 0.36 mg.mL -1 ) than the susceptible strain (IC 50 3.41 mg.mL -1 ) (Cardoso et al, 2020). Furthermore, 0.01 M of eucalyptol inhibited AChE 64.9% in larvae of the beetle Tribolium castaneum (Abdelgaleil et al, 2009).…”

Section: Resultsmentioning

confidence: 96%

Effects of essential oils on native and recombinant acetylcholinesterases of Rhipicephalus microplus

Santos

Bezerra

Temeyer

et al. 2021

Rev. Bras. Parasitol. Vet.

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This study reports the action of essential oils (EO) from five plants on the activity of native and recombinant acetylcholinesterases (AChE) from Rhipicephalus microplus. Enzyme activity of native susceptible AChE extract (S.AChE), native resistant AChE extract (R.AChE), and recombinant enzyme (rBmAChE1) was determined. An acetylcholinesterase inhibition test was used to verify the effect of the EO on enzyme activity. EO from Eucalyptus globulus, Citrus aurantifolia, Citrus aurantium var.dulcis inhibited the activity of S.AChE and R.AChE. Oils from the two Citrus species inhibited S.AChE and R.AChE in a similar way while showing greater inhibition on R.AChE. The oil from E. globulus inhibited native AChE, but no difference was observed between the S.AChE and R.AChE; however, 71% inhibition for the rBmAChE1 was recorded. Mentha piperita oil also inhibited S.AChE and R.AChE, but there was significant inhibition at the highest concentration tested. Cymbopogon winterianus oil did not inhibit AChE. Further studies are warranted with the oils from the two Citrus species that inhibited R.AChE because of the problem with R. microplus resistant to organophosphates, which target AChE. C. winterianus oil can be used against R. microplus populations that are resistant to organophosphates because its acaricidal properties act by mechanism(s) other than AChE inhibition.

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Terpenes on Rhipicephalus (Boophilus) microplus: Acaricidal activity and acetylcholinesterase inhibition

Cited by 46 publications

References 42 publications

Extraction and Mass Spectrometric Characterization of Terpenes Recovered from Olive Leaves Using a New Adsorbent-Assisted Supercritical CO2 Process

Extraction and Mass Spectrometric Characterization of Terpenes Recovered from Olive Leaves Using a New Adsorbent-Assisted Supercritical CO2 Process

The effectiveness of acaricidic drugs based on herbal raw material

Effects of essential oils on native and recombinant acetylcholinesterases of Rhipicephalus microplus

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