Terminalia pallida fruit ethanolic extract ameliorates lipids, lipoproteins, lipid metabolism marker enzymes and paraoxonase in isoproterenol-induced myocardial infarcted rats

Shaik, Althaf; Shaik, Nayab Rasool; Mohammed, Abdul Kareem; Alomar, Suliman Yousef; Mohammad, Altaf; Mohaya, Talal Abdulaziz; Kodidhela, Lakshmi Devi

doi:10.1016/j.sjbs.2017.11.002

Cited by 7 publications

(3 citation statements)

References 32 publications

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“…AAPH and SIN-1 decreased PON-1 activity, but AE and NDGA could only revert the effect exerted by SIN-1.NDGA played a key role in the effect exerted by the extract. The PON-1 protective activity of plant extracts has been reported by other authors [ 35 , 36 ].…”

Section: Discussionsupporting

confidence: 71%

Larrea divaricata: anti-inflammatory and antioxidant effects on macrophages and low density lipoproteins

Peralta

Marrassini

Martin

et al. 2022

BMC Complement Med Ther

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Background The oxidized low density lipoprotein (ox-LDL) contributes to inflammation and oxidative stress through the activation of macrophages under hyperglycemia contributing to the development of diabetes mellitus and to atherosclerosis. Plants are a source of effective and innocuous antioxidants. Larrea divaricata Cav. (Zygophyllaceae) is used in Argentina folk medicine for its anti-inflammatory properties. Methods The aim of this work was to study the antioxidant and anti-inflammatory effects of the aqueous extract (AE) of L. divaricata on macrophages under glucose stimulation and on human LDL and HDL particles under free radical generators. Results AE reduced the lipid peroxidation (17%), nitric oxide (NO) (47-50%), tumor necrosis factor-α (TNF-α) (32%) and free radicals (50%) induced by glucose on macrophages. Also prevented HDL nitration (28%), thus preserving its function and structure and inhibited LDL oxidation. The effect on the nitrosative stress was mainly driven by nordihydroguaiaretic acid (NDGA). Conclusions These results suggest a potential usefulness of AE as an adjuvant phytotherapy in patients with diabetes mellitus and atherosclerosis.

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Section: Discussionsupporting

confidence: 71%

Larrea divaricata: anti-inflammatory and antioxidant effects on macrophages and low density lipoproteins

Peralta

Marrassini

Martin

et al. 2022

BMC Complement Med Ther

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“…The ethanol solution extract was found to exhibit cardioprotective activity owing to its antioxidant effects (Shaik et al, ). In addition, it was reported to attenuate lipid metabolism marker enzymes and paraoxonase activity (Shaik et al, ). It is a commonly used herb in a large number of Ayurvedic formulations recommended for various digestive and cardiac ailments.…”

Section: Natural Products and Their Pharmacological Potential In Allementioning

confidence: 99%

Isoproterenol‐induced cardiac ischemia and fibrosis: Plant‐based approaches for intervention

Allawadhi

Khurana

Sayed

et al. 2018

Phytotherapy Research

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Heart is the most active and incumbent organ of the body, which maintains blood flow, but due to various pathological reasons, several acute and chronic cardiac complications arise out of which myocardial infarction is one of the teething problems. Isoproterenol (ISP)-induced myocardial ischemia is a classical model to screen the cardioprotective effects of various pharmacological interventions. Phytochemicals present a novel option for treating various human maladies including those of the heart. A large number of plant products and their active ingredients have been screened for efficacy in ameliorating ISP-induced myocardial ischemia including coriander, curcumin, Momordica, quercetin, and Withania somnifera. These phytochemicals constituents may play key role in preventing disease and help in cardiac remodeling. Reactive oxygen species scavenging, antiinflammatory, and modulation of various molecular pathways such as Nrf2, NFкB, p-21 activated kinase 1 (PAK1), and p-smad2/3 signaling modulation have been implicated behind the claimed protection. In this review, we have provided a focused overview on the utility of ISP-induced cardiotoxicity, myocardial ischemia, and cardiac fibrosis for preclinical research. In addition, we have also surveyed molecular mechanism of various plant-based interventions screened for cardioprotective effect in ISP-induced cardiotoxicity, and their probable mechanistic profile is summarized.

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“…Human serum PON has been shown to hydrolyze oxidized lipids and thus to decrease oxidative stress on serum lipoproteins [25]. Low activity of serum PON has been reported in diseases associated with hypercholesterolemia, atherosclerosis and increased prevalence of CVD [26].…”

Section: Introductionmentioning

confidence: 99%

Hydroalcoholic Extract of Matricaria Chamomilla Linn. Ameliorates Lipids, Lipoproteins, and Paraoxonase in Isoproterenol-Induced Myocardial Infarction in Wistar Rats

Ramachandran¹,

Adhikari

2019

Asian J Pharm Clin Res

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Objective: The objective of this study was to evaluate the effect of the hydroalcoholic extract of Matricaria Chamomilla Linn. (CHAE) on lipids, lipoproteins, and antioxidants activity in isoproterenol (ISO)-induced myocardial infarcted rats. Methods: ISO (85 mg/kg, s.c.)-induced myocardial infarction for 2 consecutive days at an interval of 24 h. Rats were pretreated with CHAE (100 and 200 mg/kg, oral) for a period of 20 days and ISO was injected on 21 and 22 days at 24 h intervals and after 24 h, blood was collected through retro-orbital plexus for the estimation of lipids, lipoproteins, and antioxidants assay. Results: In the present study, ISO caused a significant increase in the concentration of total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), very LDL-C, and lipid peroxidation whereas a significant decrease in the concentration of high-density lipoprotein-C. ISO administration also significantly decreased the activities of paraoxonase (PON) enzyme. Oral pre-treatment of CHAE at doses of 100 and 200 mg/kg body weight (bw) for 20 days challenged with a concurrent injection of ISO (85 mg/kg bw) on 21 and 22 days significantly attenuated these alterations and restored the levels of lipids and lipoproteins. In addition, CHAE significantly elevated the serum antioxidants enzyme PON and catalase (CAT). Conclusion: The report revealed that pre-treatment with CHAE ameliorated lipid and lipoprotein and increased the antioxidant PON and CAT activity and decreased LPO level in ISO-treated male albino Wistar rats.

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Terminalia pallida fruit ethanolic extract ameliorates lipids, lipoproteins, lipid metabolism marker enzymes and paraoxonase in isoproterenol-induced myocardial infarcted rats

Cited by 7 publications

References 32 publications

Larrea divaricata: anti-inflammatory and antioxidant effects on macrophages and low density lipoproteins

Larrea divaricata: anti-inflammatory and antioxidant effects on macrophages and low density lipoproteins

Isoproterenol‐induced cardiac ischemia and fibrosis: Plant‐based approaches for intervention

Hydroalcoholic Extract of Matricaria Chamomilla Linn. Ameliorates Lipids, Lipoproteins, and Paraoxonase in Isoproterenol-Induced Myocardial Infarction in Wistar Rats

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