Hydroalcoholic Extract of Matricaria Chamomilla Linn. Ameliorates Lipids, Lipoproteins, and Paraoxonase in Isoproterenol-Induced Myocardial Infarction in Wistar Rats

Abstract

Objective: The objective of this study was to evaluate the effect of the hydroalcoholic extract of Matricaria Chamomilla Linn. (CHAE) on lipids, lipoproteins, and antioxidants activity in isoproterenol (ISO)-induced myocardial infarcted rats.
 Methods: ISO (85 mg/kg, s.c.)-induced myocardial infarction for 2 consecutive days at an interval of 24 h. Rats were pretreated with CHAE (100 and 200 mg/kg, oral) for a period of 20 days and ISO was injected on 21 and 22 days at 24 h intervals and after 24 h, blood was collected through retro-orbital plexus for the estimation of lipids, lipoproteins, and antioxidants assay.
 Results: In the present study, ISO caused a significant increase in the concentration of total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), very LDL-C, and lipid peroxidation whereas a significant decrease in the concentration of high-density lipoprotein-C. ISO administration also significantly decreased the activities of paraoxonase (PON) enzyme. Oral pre-treatment of CHAE at doses of 100 and 200 mg/kg body weight (bw) for 20 days challenged with a concurrent injection of ISO (85 mg/kg bw) on 21 and 22 days significantly attenuated these alterations and restored the levels of lipids and lipoproteins. In addition, CHAE significantly elevated the serum antioxidants enzyme PON and catalase (CAT).
 Conclusion: The report revealed that pre-treatment with CHAE ameliorated lipid and lipoprotein and increased the antioxidant PON and CAT activity and decreased LPO level in ISO-treated male albino Wistar rats.

Identifying Appropriate Therapeutic Methods in Covid-19 Originated from Persian Medicine: A Review Article

“…On the other hand, recent studies have confirmed the anti-proliferative effects of several plants such as Althaea officinalis (32,33) , Glycyrrhiza glabra L. (34,35,36) , Echium amoenum (37,38,39) , Origanum majorana (40,41) and Viola odorata (42,43,44) on viruses. Furthermore, these studies reported the antioxidant properties of Althaea officinalis (32,33) , Glycyrrhiza glabra (9,34,35,36) , Matricaria chamomilla (45,46,47) and mint (48) , the repairing effect of Althaea officinalis (32,33) and Malva sylvestris (49,50,51) and also the positive effect of Matricaria chamomilla (45,46,47) and cheese in strengthening the immune system. These effects are mediated through the multiple mechanisms, especially protecting the heart, lungs and immune system by regulating the secretion of cytokines (anti-inflammatory effects) along with the balance of absorption or reabsorption of electrolytes (potassium, calcium or sodium ions).…”

“…These plants also show their therapeutic effects by improving endogenous antioxidant enzymes, regulation of signaling pathways and related kinases, as well as inhibiting of apoptotic pathways and regenerating of damaged cells or tissues. (32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)…”