Tensile testing of a single ultrafine polymeric fiber

Tan, Eunice X.; Ng, Sun Pui; Lim, Chwee Teck

doi:10.1016/j.biomaterials.2004.05.021

Cited by 312 publications

(223 citation statements)

References 14 publications

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“…Evidence for this comes from the data presented in Table 2 for electrospun fibre networks. Data for single electrospun fibres is scarce in the literature, but one study has reported tensile moduli of *120 MPa for single PCL fibres [30]. A value of 6 MPa for the PCL networks [6] (it is noted that this value is with fillers) is much lower than 1/3 of 120 MPa (40 MPa), and so it is reasonable to assume that Eq.…”

Section: Micromechanical Modelling Of Tensile Modulus Of Composite Fimentioning

confidence: 99%

Orientation of cellulose nanocrystals in electrospun polymer fibres

et al. 2015

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Polystyrene and poly(vinyl alcohol) nanofibres containing cellulose nanocrystals (CNCs) were successfully produced by electrospinning. Knowledge of the local orientation of CNCs in electrospun fibres is critical to understand and exploit their mechanical properties. The orientation of CNCs in these electrospun fibres was investigated using transmission electron microscopy (TEM) and Raman spectroscopy. A Raman band located at *1095 cm -1 , associated with the C-O ring stretching of the cellulose backbone, was used to quantify the orientation of the CNCs within the fibres. Raman spectra were fitted using a theoretical model to characterize the extent of orientation. From these data, it is observed that the CNCs have little orientation along the direction parallel to the axis of the fibres. Evidences for both oriented and nonoriented regions of CNCs in the fibres are presented from TEM images of nanofibres. These results contradict previously published work in this area and micromechanical modelling calculations suggest a uniform orientation of CNCs in electrospun polymer fibres. It is demonstrated that this explains why the mechanical properties of electrospun fibre mats containing CNCs are not always the same as that would be expected for a fully oriented system.

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Section: Micromechanical Modelling Of Tensile Modulus Of Composite Fimentioning

confidence: 99%

Orientation of cellulose nanocrystals in electrospun polymer fibres

et al. 2015

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“…Of these few, perhaps most common is the microtensile testing of single fibers. In one study by Tan and colleagues, 97 single PCL fibers were collected across a small gap, and uniaxial extension applied until failure was achieved. They reported that smaller fibers have a higher modulus, but are less ductile than larger fibers.…”

Section: Single-fiber Mechanicsmentioning

confidence: 99%

Engineering on the Straight and Narrow: The Mechanics of Nanofibrous Assemblies for Fiber-Reinforced Tissue Regeneration

Mauck

Baker

Nerurkar

et al. 2009

Tissue Engineering Part B: Reviews

189

177

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Tissue engineering of fibrous tissues of the musculoskeletal system represents a considerable challenge because of the complex architecture and mechanical properties of the component structures. Natural healing processes in these dense tissues are limited as a result of the mechanically challenging environment of the damaged tissue and the hypocellularity and avascular nature of the extracellular matrix. When healing does occur, the ordered structure of the native tissue is replaced with a disorganized fibrous scar with inferior mechanical properties, engendering sites that are prone to re-injury. To address the engineering of such tissues, we and others have adopted a structurally motivated approach based on organized nanofibrous assemblies. These scaffolds are composed of ultrafine polymeric fibers that can be fabricated in such a way to recreate the structural anisotropy typical of fiber-reinforced tissues. This straight-and-narrow topography not only provides tailored mechanical properties, but also serves as a 3D biomimetic micropattern for directed tissue formation. This review describes the underlying technology of nanofiber production and focuses specifically on the mechanical evaluation and theoretical modeling of these structures as it relates to native tissue structure and function. Applying the same mechanical framework for understanding native and engineered fiber-reinforced tissues provides a functional method for evaluating the utility and maturation of these unique engineered constructs. We further describe several case examples where these principles have been put to test, and discuss the remaining challenges and opportunities in forwarding this technology toward clinical implementation.

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“…To accurately investigate the mechanical behavior of nanofibrous scaffolds, it is essential to measure the mechanical properties of individual fibers that make up the scaffold [63]. Such tensile testers must possess the capability of measuring the small load and elongation required for the deformation of these ultrafine fibers, including individual fibers [63,64].…”

Section: Mechanical Propertiesmentioning

confidence: 99%

Electrospinning Technology for Nanofibrous Scaffolds in Tissue Engineering

Li¹,

Shanti²,

Tuan³

2003

Nanotechnologies for the Life Sciences

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The sections in this article are Introduction Nanofibrous Scaffolds Fabrication Methods for Nanofibrous Scaffolds Phase Separation Self‐assembly Electrospinning The Electrospinning Process History Setup Mechanism and Working Parameters Properties of Electrospun Nanofibrous Scaffolds Architecture Porosity Mechanical Properties Current Development of Electrospun Nanofibrous Scaffolds in Tissue Engineering Evidence Supporting the Use of Nanofibrous Scaffolds in Tissue Engineering Nanofibrous Scaffolds Enhance Adsorption of Cell Adhesion Molecules Nanofibrous Scaffolds Induce Favorable Cell– ECM Interaction Nanofibrous Scaffolds Maintain Cell Phenotype Nanofibrous Scaffolds Support Differentiation of Stem Cells Nanofibrous Scaffolds Promote in vivo ‐like 3 D Matrix Adhesion and Activate Cell Signaling Pathway Biomaterials Electrospun into Nanofibrous Scaffolds Natural Polymeric Nanofibrous Scaffolds Synthetic Polymeric Nanofibrous Scaffolds Composite Polymeric Nanofibrous Scaffolds Nanofibrous Scaffolds Coated with Bioactive Molecules Engineered Tissues using Electrospun Nanofibrous Scaffolds Skin Blood Vessel Cartilage Bone Muscle Ligament Nerve Current Challenges and Future Directions Conclusion

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Tensile testing of a single ultrafine polymeric fiber

Cited by 312 publications

References 14 publications

Orientation of cellulose nanocrystals in electrospun polymer fibres

Orientation of cellulose nanocrystals in electrospun polymer fibres

Engineering on the Straight and Narrow: The Mechanics of Nanofibrous Assemblies for Fiber-Reinforced Tissue Regeneration

Electrospinning Technology for Nanofibrous Scaffolds in Tissue Engineering

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