Electrospinning Technology for Nanofibrous Scaffolds in Tissue Engineering

Abstract

The sections in this article are Introduction Nanofibrous Scaffolds Fabrication Methods for Nanofibrous Scaffolds Phase Separation Self‐assembly Electrospinning The Electrospinning Process History Setup Mechanism and Working Parameters Properties of Electrospun Nanofibrous Scaffolds Architecture Porosity Mechanical Properties Current Development of Electrospun Nanofibrous Scaffolds in Tissue Engineering Evidence Supporting the Use of Nanofibrous Scaffolds in Tissue Engineering Nanofibrous Scaffolds Enhance Adsorption of Cell Adhesion Molecules Nanofibrous Scaffolds Induce Favorable Cell– ECM Interaction Nanofibrous Scaffolds Maintain Cell Phenotype Nanofibrous Scaffolds Support Differentiation of Stem Cells Nanofibrous Scaffolds Promote in vivo ‐like 3 D Matrix Adhesion and Activate Cell Signaling Pathway Biomaterials Electrospun into Nanofibrous Scaffolds Natural Polymeric Nanofibrous Scaffolds Synthetic Polymeric Nanofibrous Scaffolds Composite Polymeric Nanofibrous Scaffolds Nanofibrous Scaffolds Coated with Bioactive Molecules Engineered Tissues using Electrospun Nanofibrous Scaffolds Skin Blood Vessel Cartilage Bone Muscle Ligament Nerve Current Challenges and Future Directions Conclusion

New directions in nanofibrous scaffolds for soft tissue engineering and regeneration

“…As this length scale mimics that of native collagen fibrils ex vivo , nanofibers are an ideal substrate for tissue engineering applications. Aside from the morphological similarity to collagen, scaffolds formed by electrospinning also have a high surface area-to-volume ratio, variable pore-size distribution, and high porosity [65]. …”

Design and manufacture of neural tissue engineering scaffolds using hyaluronic acid and polycaprolactone nanofibers with controlled porosity

“…When the electrical field overcomes the surface tension of solution, the solution is thrown with intensity to the rotating collector [12][13][14].This method is a powerful technique for producing fibers with controlled diameter and morphology [15]. Morphology of fibers is one of important parameters to control the properties of electrospun scaffolds in tissue engineering [16,17]. the electrospun fibrous scaffold possess useful characteristics such as, nano scale fibers which provide high-specific surface area and high porosity with very small pore size, which can mimic the extracellular matrix (ECM) and enhance the cell migration and proliferation, and are especially suitable for neural tissue applications [18][19][20][21].…”

Evaluation and comparison of the in vitro characteristics and chondrogenic capacity of four adult stem/progenitor cells for cartilage cell‐based repair

“…3 An ideal scaffold should have proper physical and topographical properties, be non-immunogenic, biodegradable and biocompatible. 17 Culturing the appropriate cells on a proper scaffold and further transplantation of the engineered cartilage construct into the lesion have proved very effective in cartilage tissue engineering. 18 Various natural and synthetic materials have been tested for cartilage tissue engineering.…”