Tensile strength of tablets containing two materials with a different compaction behaviour

Veen, Bert van; Maarschalk, Kees van der Voort; Bolhuis, G.K.; Zuurman, K.; Frijlink, Henderik W.

doi:10.1016/s0378-5173(00)00450-6

Cited by 65 publications

(18 citation statements)

References 16 publications

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“…Dissolution rate is a highly sensitive test that can be influenced by numerous factors related to the physicochemical properties of the drug substance, product formulation, manufacturing processes and dissolution testing conditions (Lee et al, 2008). The mechanical strength of a tablet depends on both formulation and processing parameters (van Veen et al, 2000). So, on one hand, it was not surprising that formulation variables correlated so strongly with the mean dissolution time and tensile strength and, on the other, it was interesting to note, as discussed before, that no quantifiable effect was found for the manufacture process.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the ability of powdered milk to produce minitablets containing paracetamol for the paediatric population

Pinto

Brachkova

Fernandes

et al. 2016

Chemical Engineering Research and Design

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The work aims at evaluating the usefulness of powdered milk as a drug matrix for the production of minitablets specifically designed for children. Mixtures made of powdered milk, paracetamol, mannitol, sodium croscarmellose and magnesium stearate (evaluated for flow properties, cohesiveness and caking tendency) were compacted into beams (evaluated for deformation, elasticity and stiffness) and minitablets (evaluated for uniformity of mass, thickness, tensile strength and paracetamol mean dissolution time) and a 2 3 factorial design performed. The increase on milk fraction in the formulation improved the compressibility of paracetamol and hardness of compacts, reducing weight variation and paracetamol release. A marked decrease on the dissolution time was observed as sodium croscarmellose was added to the milk rich formulations. The increase of the compression force resulted in the production of thinner compacts but had little effect on dissolution time. The production of beams has shown that deformation, bending strength and stiffness increased with both milk and compaction pressure, and decreased with sodium croscarmellose, whereas elasticity decreased when all variables increased. Tensile strength and mean dissolution time described minitablets well, unlike compaction force. The study has proved that powdered milk is suitable for the production of minitablets by direct compression of poor compressible drugs. Highlights-Powdered milk can be used as a matrix to deliver poorly compressible drugs.-Minitablets can be produced by direct compression of drug and powdered milk.-Materials' behaviour is different as powders, compacts or tablets.-The complexity of milk materials justifies unexpected outcomes for compacts and tablets.-Mean drug dissolution time was the most sensitive parameter to assess tablets' performance.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the ability of powdered milk to produce minitablets containing paracetamol for the paediatric population

Pinto

Brachkova

Fernandes

et al. 2016

Chemical Engineering Research and Design

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“…1c shows the linear relationship of effect of compression force and tablet diameter on tablet porosity. Compression decreases the intermolecular voids resulting in densification, inter-particle bonding to enhanced binding and densification of tablets (Van Veen et al, 2000). Both enhanced binding and densification results in increased tablet hardness and tensile strength.…”

Section: Analysis Of the Fitted Data -Hardness (Y1) And Porosity (Y3)mentioning

confidence: 99%

Application of face centred central composite design to optimise compression force and tablet diameter for the formulation of mechanically strong and fast disintegrating orodispersible tablets

Pabari¹,

Ramtoola²

2012

International Journal of Pharmaceutics

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“…When compression forces are low (Figure 7c), sodium chloride particles partially fragment or maintain their original shapes and predominantly deform at the particle corners. 16 Several sodium chloride particles preserve their smooth surfaces and related mirror facets (Figure 7a). Nevertheless, the tablet surface is rough at a macroscopic scale because of the random packing of relative large and unaltered sodium chloride particles (106-212 μm) and large pores between the particles as measured by stylus profilometer (Figure 3).…”

Section: Sem Images Of Sodium Chloride Tablet Surfacesmentioning

confidence: 99%

“…At higher compression forces (Figure 7d), particles fragment and deform completely and cracks occur in the sodium chloride crystal structure. 16,17 The mirror property of single particles becomes worse, which leads to a reduction in gloss (Figure 7b). The tablet surface roughness at a macroscopic scale is flattened out at higher compression forces, while the highly deformed sodium chloride particles and cracked crystal structures maintain less gloss.…”

Section: Sem Images Of Sodium Chloride Tablet Surfacesmentioning

confidence: 99%

Local and average gloss from flat-faced sodium chloride tablets

et al. 2006

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The purpose of this study was to detect local gloss and surface structure changes of sodium chloride tablets. The changes in surface structure were reflected by gloss variation, which was measured using a diffractive optical element-based glossmeter (DOG). By scanning a surface area, we constructed a 2-dimensional gloss map that characterized the tablet's surface structure. The gloss variation results were compared with scanning electron microscopy (SEM) images and average surface roughness values that were measured by conventional diamond stylus profilometry. The profilometry data showed a decrease in tablet surface roughness as a function of compression force. In general, a smoother surface contributes to higher average gloss values. The average gloss values for this material, in contrast, showed a decrease as a function of the compression force. The sequence of particle fragmentation and deformation together with crack formation in sodium chloride particles resulted in a loss of gloss for single sodium chloride particles at the tablet surfaces, which could be detected by the DOG. These results were supported by the SEM images. The results show that detailed information regarding tablets' surface structure changes can be obtained by detection of local gloss variation and average gloss.

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Tensile strength of tablets containing two materials with a different compaction behaviour

Cited by 65 publications

References 16 publications

Evaluation of the ability of powdered milk to produce minitablets containing paracetamol for the paediatric population

Evaluation of the ability of powdered milk to produce minitablets containing paracetamol for the paediatric population

Application of face centred central composite design to optimise compression force and tablet diameter for the formulation of mechanically strong and fast disintegrating orodispersible tablets

Local and average gloss from flat-faced sodium chloride tablets

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