Application of face centred central composite design to optimise compression force and tablet diameter for the formulation of mechanically strong and fast disintegrating orodispersible tablets

Pabari, Ritesh M.; Ramtoola, Zebunnissa

doi:10.1016/j.ijpharm.2012.03.021

Cited by 82 publications

(55 citation statements)

References 24 publications

(20 reference statements)

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“…X 1 X 2 ) shows the changes in response when two factors are simultaneously changed (Pathan et al, 2013), while factors at higher order (X n 2 ) represents the quadratic relationships (i.e. non-linearity) (Pabari and Ramtoola, 2012;Zhang et al, 2013).…”

Section: General Multilevel Factorial Design-statistical Analysis Andmentioning

confidence: 99%

“…Great efforts have been used to enhance properties of FDTs and adapt the conventional tableting formulation or the process used (Pabari and Ramtoola, 2012) in order to compromise between the two parameters mechanical strength and disintegration time. Kuno et al (2005) evaluated rapidly disintegrating tablets manufactured by phase transition of sugar alcohols.…”

Section: Introductionmentioning

confidence: 99%

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Application of general multilevel factorial design with formulation of fast disintegrating tablets containing croscaremellose sodium and Disintequick MCC-25

Solaiman

Suliman

Shinde

et al. 2016

International Journal of Pharmaceutics

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A B S T R A C TDespite the popularity of orally fast disintegrating tablets (FDTs), their formulation can sometimes be challenging, producing tablets with either poor mechanical properties or high disintegration times. The aim of this research was to enhance the properties of FDTs produced by direct compression to have both sufficient hardness to withstand manual handling, and rapid disintegration time. General multilevel factorial design was applied to optimise and evaluate main and interaction effects of independent variables (i) disintegrant concentration, (ii) % filler (Disintequick MCC-25) to mannitol on the responses hardness, tensile strength and disintegration time. In this experiment mannitol was used as a diluent, Disintequick MCC-25 (to best of our knowledge there is no publication available yet for its use with FDTs) was termed in this study as a filler and croscaremellose sodium was used as the superdisintegrant. ) and friability of 2.2%; (ii) 7% or 10% w/w disintegrant with 33.33% w/w filler to mannitol, showing disintegration time of 84 s (for 7% disintegrant) and 107 s (for 10% disintegrant), hardness of 73.86 N (for 7% disintegrant) and 72.68 N (for 10% disintegrant) and friability of 1.44 (for 7% disintegrant) and 1.15% (for 10% disintegrant).

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Section: General Multilevel Factorial Design-statistical Analysis Andmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Application of general multilevel factorial design with formulation of fast disintegrating tablets containing croscaremellose sodium and Disintequick MCC-25

Solaiman

Suliman

Shinde

et al. 2016

International Journal of Pharmaceutics

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show abstract

“…A statistical optimization tool based on response surface methodology and experimental formulations, such as central composite, Box-Behnken, factorial, and mixture designs, 16,[30][31][32][33][34][35][36] has been used widely, because it can evaluate the main effects and interaction of all variables simultaneously. Hence, response surface methodology with a constrained mixture design was used to develop an optimal citalopram-loaded microemulsion for topical application, and the effect of composition of the microemulsion on the ability of citalopram to permeate rat skin was investigated.…”

Section: Introductionmentioning

confidence: 99%

Effect of microemulsions on transdermal delivery of citalopram: optimization studies using mixture design and response surface methodology

Huang¹,

Tsai²,

Lin³

et al. 2013

IJN

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Abstract:The aim of this study was to evaluate the potential of microemulsions as a drug vehicle for transdermal delivery of citalopram. A computerized statistical technique of response surface methodology with mixture design was used to investigate and optimize the influence of the formulation compositions including a mixture of Brij 30/Brij 35 surfactants (at a ratio of 4:1, 20%-30%), isopropyl alcohol (20%-30%), and distilled water (40%-50%) on the properties of the drug-loaded microemulsions, including permeation rate (flux) and lag time. When microemulsions were used as a vehicle, the drug permeation rate increased significantly and the lag time shortened significantly when compared with the aqueous control of 40% isopropyl alcohol solution containing 3% citalopram, demonstrating that microemulsions are a promising vehicle for transdermal application. With regard to the pharmacokinetic parameters of citalopram, the flux required for the transdermal delivery system was about 1280 µg per hour. The microemulsions loaded with citalopram 3% and 10% showed respective flux rates of 179.6 µg/cm 2 and 513.8 µg/cm 2 per hour, indicating that the study formulation could provide effective therapeutic concentrations over a practical application area. The animal study showed that the optimized formulation (F15) containing 3% citalopram with an application area of 3.46 cm 2 is able to reach a minimum effective therapeutic concentration with no erythematous reaction.

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“…This design allowed the response surface to be modelled by performing the number of experiments equal to 2k+2k+1, where k is the number of variables (k=3), which makes a total of 13 experiments to be executed as per CCD design. 18 Three-dimensional response surface plots are given in Fig. 1 and are highly imperative in order to study the effects of the factors and their interaction on the selected responses.…”

Section: Resultsmentioning

confidence: 99%

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2017

IJPSR

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A novel method of estimation and validation of Atorvastatin by Reverse Phase-High Performance Liquid Chromatography coupled with Ultra-violet detection was developed which had high potential in determining drug concentration in rat plasma samples during preclinical studies. Atorvastatin being >99% protein bound, exhibits great challenge in getting extracted from plasma samples. Hence, by treating them with strong protein precipitating agents, that is, initially with 10% w/v perchloric acid and further treating its supernatant with mixture of 2M potassium carbonate and 3M of potassium hydroxide, drug extraction was facilitated. Diclofanac sodium was the selected internal standard. Process of elution was conducted using Phenomenex C 18 column and mobile phase comprising of a mixture of methanol: water in 70:30 ratio adjusted to pH 5.5. This precise method was linear between a range of 10 to 1000 ng/ml with limit of detection and quantification as 10ng/ml and 15ng/ml respectively. 2-factor 3-level face centred Central Composite Design was employed using Design Expert Software ver. 8.0.0 to examine effect of independent chromatographic factors like pH of the mobile and methanol: water ratio on the dependent factors like retention time, theoretical plates and tailing factor. The ANOVA studies proved that the model employed for this study was significant. Further, to improve applicability, marketed drug formulation was spiked in rat plasma and developed method was applied for drug detection.

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Application of face centred central composite design to optimise compression force and tablet diameter for the formulation of mechanically strong and fast disintegrating orodispersible tablets

Cited by 82 publications

References 24 publications

Application of general multilevel factorial design with formulation of fast disintegrating tablets containing croscaremellose sodium and Disintequick MCC-25

Application of general multilevel factorial design with formulation of fast disintegrating tablets containing croscaremellose sodium and Disintequick MCC-25

Effect of microemulsions on transdermal delivery of citalopram: optimization studies using mixture design and response surface methodology

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