Ten SNPs of PAX6,<i>Lumican</i>, and<i>MYOC</i>genes are not associated with high myopia in Han Chinese

BackgroundsMany studies have evaluated the association between lumican (LUM) gene polymorphisms and high myopia. However, the results remain controversial. This meta-analysis aims to comprehensively evaluate the relationship between two common LUM polymorphisms (rs3759223 and rs3759222) and the risk of high myopia.MethodsA comprehensive literature search for studies published up until September of 2013 was performed. Data were extracted independently by two investigators, and the weighted Odds Ratios (ORs) and 95% Confidence Intervals (CIs) for the associations were obtained by using a random-effects model.ResultsEight studies (1425cases and 1271 controls) were identified for the analysis of the association between rs3759223 polymorphism and high myopia. The results indicated that rs3759223 polymorphism was associated with high myopia under a recessive model (OR = 1.71, 95%CI 1.04–2.81). Further subgroup analysis indicated that this polymorphism was associated with high myopia among Chinese people in the additive model (OR = 1.17, 95%CI 1.06–1.29) and a recessive model (OR = 1.75, 95%CI 1.00–3.06) with control group coming from hospital based population. Four studies (1024 cases and 1163 controls) were identified for the analysis of the association between rs3759222 polymorphism and high myopia. The results indicated that rs3759222 polymorphism was not associated with high myopia in all genetic models, even the subgroup analysis couldn't provide relative proof to assure the outcome.ConclusionThis meta-analysis suggests that LUM polymorphisms are associated with the risk of high myopia. However, well-designed studies with larger sample sizes and more ethnic groups are required to further validate this association.

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“…The LUM gene is a member of SLRP gene family [11]. Proteoglycans are major components of the scleral extracellular matrix.…”

Section: Discussionmentioning

confidence: 99%

Meta-Analysis of the Association between Lumican Gene Polymorphisms and Susceptibility to High Myopia

Wang

Ragoonundun

et al. 2014

PLoS ONE

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“…After screening, we examined the association of the rs3759223 promoter polymorphism with high myopia in Chinese populations. Of the 5 studies in this meta-analysis, 3 showed an association between the rs3759223 promoter polymorphism and high myopia [22,24,26], whereas the other 2 suggested no association [3,28]. To our knowledge, this meta-analysis provides the most comprehensive assessment thus far of the relevance of the lumican promoter polymorphism (rs3759223) to high myopia.…”

Section: Discussionmentioning

confidence: 99%

“…Studies by Chen et al [23] and Lin et al [2] were excluded because their patient samples overlapped with those of Wang et al [26] and Lin et al [22], respectively. Therefore, 5 studies involving 1,545 participants were included [3,22,24,26,28 ](table 1). All subjects were Chinese and were selected randomly without sex or age restriction.…”

Section: Resultsmentioning

confidence: 99%

“…The phenotype of the lumican-deficient mouse and zebrafish implicates lumican as a functional candidate gene for high myopia [19,21]. Several high-frequency single-nucleotide polymorphisms have been identified in lumican [22,26], some of which may contribute to the pathogenesis of high myopia [2,22,23,24,25,26]; however, other genetic association studies suggest that lumican polymorphisms are not associated with this condition [3,6,27,28]. Some lumican SNPs such as rs17018718 and rs3759222 were described in only 1 or 2 studies [24,26,27].…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, several genetic association studies have reported that lumican polymorphisms contribute to the pathogenesis of high myopia [2,22,23,24,25,26]. However, other studies have suggested lumican polymorphisms are not associated with high myopia [3,6,27,28]. We performed a meta-analysis to produce a precise, reliable estimation of the association between lumican polymorphisms and high myopia.…”

Section: Introductionmentioning

confidence: 99%

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Association between a Lumican Promoter Polymorphism and High Myopia in the Chinese Population: A Meta-Analysis of Case-Control Studies

Deng¹,

Shi

Song

et al. 2014

Ophthalmologica

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Purpose: To evaluate the relationship between lumican polymorphisms and high myopia in Chinese populations. Methods: An electronic search was conducted in Pubmed, Embase, Cochrane Library and the China Biological Medicine Database for articles published prior to September 30, 2012. A meta-analysis was performed to assess heterogeneity, combine results and determine publication bias. Results: This meta-analysis, including 1,545 subjects from 5 studies, indicated that Chinese lumican rs3759223 C allele carriers had a decreased risk of high myopia in comparison to T allele carriers (odds ratio: 0.531; 95% confidence interval, CI: 0.304-0.925; p = 0.025). There was some heterogeneity between studies. A metaregression showed that the mean axial length of controls weakens the effect of rs3759223 on high myopia (slope: -0.914; 95% CI: -1.490 to 0.337; p = 0.002). Sensitivity analysis confirmed the reliability and stability of this meta-analysis. Conclusion: Chinese lumican rs3759223 C allele carriers may be at reduced risk of high myopia.

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Genes Involved in the Development of Myopia

Yamashiro

Yoshimura

2013

Pathologic Myopia

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Ten SNPs of PAX6,Lumican, andMYOCgenes are not associated with high myopia in Han Chinese

Abstract: Our results confirm that the PAX6, Lumican, and MYOC genes were not associated with high myopia in the Han Chinese in Northeastern China.

Cited by 17 publications

References 32 publications

Meta-Analysis of the Association between Lumican Gene Polymorphisms and Susceptibility to High Myopia

Meta-Analysis of the Association between Lumican Gene Polymorphisms and Susceptibility to High Myopia

Association between a Lumican Promoter Polymorphism and High Myopia in the Chinese Population: A Meta-Analysis of Case-Control Studies

Genes Involved in the Development of Myopia

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