Genes Involved in the Development of Myopia

Yamashiro, Kenji; Yoshimura, Nagahisa

doi:10.1007/978-1-4614-8338-0_2

Cited by 1 publication

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References 89 publications

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“…But whether high myopia that is caused by environmental factors gradually develops into pathologic myopia remains unclear. The occurrence of myopia and high myopia may also have a genetic cause, as at least 19 myopia loci have been identified through family studies and twin studies (Yamashiro 2014). However, the pathogenic myopia genes are not fully characterized, nor have genes associated with fundus lesions been identified.…”

Section: Introductionmentioning

confidence: 99%

Design and Pilot data of the high myopia registration study: Shanghai Child and Adolescent Large‐scale Eye Study (SCALE‐HM)

Deng

et al. 2020

Acta Ophthalmologica

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Purpose To describe the methodology and pilot data of the Shanghai Child and Adolescent Large‐scale Eye Study (SCALE‐HM). Methods This is a population‐based, prospective, examiner‐masked study with annual follow‐up. Patients are 4‐ to 18‐year‐olds with high myopia. The participants will fill out questionnaires and then undergo visual acuity, axial length (AL), intraocular pressure, ophthalmologist assessment, microperimetry, cycloplegic refraction, Pentacam, wavefront aberration, fundus, blood and saliva examinations. To describe the pilot data, intergroup differences were assessed with t‐tests or analysis of variance and a logistic regression model was used to determine the independent factors associated with peripapillary atrophy (PPA). Results Overall, 134 eyes of 79 participants met the pilot study recruitment criteria. The mean AL and spherical equivalent were 26.91 ± 1.07 mm and −9.40 ± 1.77 D, respectively. Peripapillary atrophy (PPA) (N = 112) and tessellated fundus (N = 67) were the most common fundus changes. The mean AL was significantly longer in PPA (27.08 ± 0.93 mm) than in non‐PPA eyes (26.06 ± 1.31 mm; p < 0.001). Axial length (AL) (p = 0.041) was the only independent factor associated with PPA. Axial length (AL) was significantly longer in eyes with diffuse chorioretinal atrophy (N = 11; 28.02 ± 1.31 mm) than without myopic retinal lesions (N = 56; 26.48 ± 0.91 mm, p < 0.001) or with tessellated fundus (N = 67; 27.09 ± 0.97 mm, p = 0.012). The myopic degree was higher in eyes with diffuse chorioretinal atrophy than without myopic retinal lesions (−10.51 ± 2.76 D versus −9.06 ± 1.58 D, p = 0.039). Conclusion Peripapillary atrophy and tessellated fundus were common in children and adolescents with high myopia. Results from this prospective study will help to understand the mechanisms, development and prognosis of these changes and can guide early myopia screening.

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Section: Introductionmentioning

confidence: 99%

Design and Pilot data of the high myopia registration study: Shanghai Child and Adolescent Large‐scale Eye Study (SCALE‐HM)

Deng

et al. 2020

Acta Ophthalmologica

View full text Add to dashboard Cite

show abstract

Genes Involved in the Development of Myopia

Cited by 1 publication

References 89 publications

Design and Pilot data of the high myopia registration study: Shanghai Child and Adolescent Large‐scale Eye Study (SCALE‐HM)

Design and Pilot data of the high myopia registration study: Shanghai Child and Adolescent Large‐scale Eye Study (SCALE‐HM)

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