Temporary diabetes mellitus secondary to a primary pancreatic Burkitt lymphoma

Abstract

Primary pancreatic lymphoma (PPL) is a rare form of extranodal lymphoma. So far, only in adults has a coincidence with diabetes mellitus (DM) been described. We report a nearly 9-year-old German boy presenting with a Burkitt lymphoma associated with a temporary insulin-dependent DM and exocrine insufficiency of the pancreas. After the patient went into remission, a spontaneous recovery of the endocrine pancreatic function was observed. On immunophenotyping, the lymphoma cells revealed expression of FasL suggesting a potentially apoptotic effect on pancreatic tissue. Beta cell impairment may have been caused by FasL resembling autoimmune diabetes.

Bifocal primary pancreatic Burkitt's lymphoma in a 4‐year‐old child

“…3, MARCH/APRIL 2017 described to cause bile and pancreatic duct dilatation and mimic acute cholestatic hepatitis, 6 to present as acute pancreatitis, 7 and also to induce temporary diabetes mellitus. 8 In our case, the clues for diagnosis were mainly the US features of the lesions, which were solid, homogeneous, and hypoechoic with no cystic component or calcification, and obstructive jaundice as well as rapid evolution of the clinical picture within 2 weeks.…”

“…Primary Burkitt's lymphoma of the pancreas is extremely rare with only a few cases described in the literature; some of these cases describe a single mass lesion, whereas other cases describe diffuse pancreatic involvement . Primary pancreatic lymphoma has been described to cause bile and pancreatic duct dilatation and mimic acute cholestatic hepatitis, to present as acute pancreatitis, and also to induce temporary diabetes mellitus …”

Pancreatic Involvement of Burkitt Lymphoma in a Child and Review of the Literature

“…Pancreatic involvement rarely detected in childhood NHL [1][2][3][4][7][8][9][10][11]. Table I Pancreatic involvement of BL may be considered one of the causes of pancreatitis in children and can be overlooked in differential diagnosis of pancreatic masses.…”

Primary Pancreatic Lymphoma in a Patient with Maturity Onset Diabetes of the Young type 3

“…Diabetes Mellitus has been reported as presenting symptom associated to PPL, related to the lymphoma infiltration of pancreatic tissue and the following exocrine and endocrine insufficiency, with spontaneous recovery of pancreatic function after treatment-induced lymphoma remission 5,6…”