2017
DOI: 10.1038/srep40866
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Temporal variations in presynaptic release probability in the lateral habenula

Abstract: Rhythmicity plays an important role in a number of biological systems. The habenular complex is reported to contain an intrinsic molecular clock and to show rhythmic expression of circadian clock genes and proteins including per2/PER2. In this study, we observed that there is a temporal rhythmicity in the presynaptic efficacy of the lateral habenula (LHb) neurons. We collected a substantial number of recordings at different time points of the day during the light phase. The frequency and amplitude of spontaneo… Show more

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Cited by 10 publications
(9 citation statements)
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“…Ventral to the hippocampus lies the PVT and LHb. The PVT has recently been proposed to be involved in long-term fear memory storage (Arruda-Carvalho and Clem, 2015 ; Do-Monte et al, 2015b ; Penzo et al, 2015 ), and the LHb is related to depression-like behaviors (Matsumoto and Hikosaka, 2007 , 2009 ; Li et al, 2011 ; Park et al, 2017a , b , c ). 129S1 mice exhibited higher activity in the PVT after contextual fear extinction.…”
Section: Discussionmentioning
confidence: 99%
“…Ventral to the hippocampus lies the PVT and LHb. The PVT has recently been proposed to be involved in long-term fear memory storage (Arruda-Carvalho and Clem, 2015 ; Do-Monte et al, 2015b ; Penzo et al, 2015 ), and the LHb is related to depression-like behaviors (Matsumoto and Hikosaka, 2007 , 2009 ; Li et al, 2011 ; Park et al, 2017a , b , c ). 129S1 mice exhibited higher activity in the PVT after contextual fear extinction.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, whole‐cell recordings in the LHb reveal that the time of day changes in LHb firing frequency—which is usually lower in early day compared to the late day—are lost in Cry1/2 ‐deficient mice (Sakhi, Wegner, et al., ). It is important to note that temporal differences in firing frequency (Zhao & Rusak, ) may be due to presynaptic input rather than intrinsic LHb activity because Park, Cheon, Kim, and Chung () reported an increase in mini‐excitatory postsynaptic current (mEPSC) frequency and paired‐pulse ratio (when stimulating in stria medullaris) in afternoon compared to morning.…”
Section: Epithalamus: Habenula (Medial and Lateral)mentioning
confidence: 99%
“…Further research into the mechanisms underlying co-released glutamate and GABA in LHb may provide novel insights into such motivational states as well as disorders involving the LHb. Some recent observations include that excitatory and inhibitory LHb synapses exhibit differential plasticity modulated by distinct mechanisms (Valentinova and Mameli, 2016), that glutamate and GABA release are differentially regulated by mu opioid receptor activation (Margolis and Fields, 2016), that GABA receptors are specifically internalized in response to stress (Lecca et al, 2016), that AMPA receptors are enhanced at excitatory synapses following cocaine exposure (Marteau and Mamelli, 2012; Meye et al, 2015), and that LHb neurotransmission undergoes circadian modulations (Park et al, 2017). …”
Section: Afferent Connectionsmentioning
confidence: 99%