“…Moreover, symptoms, perceived stress and neurobiological markers may fluctuate over time, dissociate from, or converge with each other at various points, and trajectories of specific markers may ultimately differ across high-risk groups. For example, although diurnal cortisol elevations may develop proximally to the onset of illness, there is evidence that other static markers (such as HV) emerge much earlier in the course of illness (Francis et al, 2013;Lawrie et al, 2002). Ultimately, longitudinal studies of subjects at familial and clinical high-risk for psychosis will be required to illuminate the dynamic course of stress-vulnerability along the psychosis continuum.…”