Bilateral hippocampal volume increases after long-term lithium treatment in patients with bipolar disorder: a longitudinal MRI study

Yücel, Kaan; McKinnon, Margaret C.; Taylor, Valerie H.; MacDonald, Kathryn; Alda, Martin; Young, L. Trevor; MacQueen, Glenda

doi:10.1007/s00213-007-0906-9

Cited by 193 publications

(143 citation statements)

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“…[14][15][16][17][18] However, most of these studies were confounded by effects of medication, which is known to increase mesiotemporal volumes. 21 We controlled for potential confounding effect of medication in the design of our study.…”

Section: Discussionmentioning

confidence: 99%

“…If mesiotemporal volumes are an endophenotype for BD, then affected offspring should show the largest differences relative to control subjects, with intermediate volumes among unaffected patients. As most studies reported lack of hippocampal volume changes 21 and decreased amygdala volumes in young patients with BD, 20 we expected to find comparable hippocampal and decreased amygdala volumes both in affected and in unaffected offspring of patients with BD relative to control subjects.…”

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confidence: 86%

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Amygdala and Hippocampal Volumes in Relatives of Patients with Bipolar Disorder: A High—Risk Study

et al. 2009

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M esiotemporal structures including hippocampus and amygdala have been implicated in the pathophysiology of BD by converging evidence from structural, 1 functional neuroimaging, 2 neuropathological, 3 and neurocognitive 4 studies. Structural neuroimaging findings regarding the amygdala are markedly heterogeneous, with findings of decreased, 5-8 unchanged, 9-13 as well as increased 14-18 amygdala volumes in patients with BD relative to control subjects. Similarly, the literature regarding hippocampal volumes is inconsistent with most studies reporting lack of hippocampal volume changes, 7,14-16 but also with findings of decreased 10 as well as increased 5,19 hippocampal volumes in patients with BD. These discrepancies likely reflect clinical and treatment heterogeneity. 20,21

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Section: Discussionmentioning

confidence: 99%

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confidence: 86%

Amygdala and Hippocampal Volumes in Relatives of Patients with Bipolar Disorder: A High—Risk Study

et al. 2009

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“…Lithium treatment has been associated with increased gray matter volumes in general [Moore et al 2000], and in particular brain regions such as the hippocampus [Foland et al 2008;Yucel et al 2007], and the amygdala [Usher et al 2010;Foland et al 2008]. Recently, several studies have examined whether such gray matter changes correlate with lithium response rather than simply treatment.…”

Section: Bipolar Disordermentioning

confidence: 99%

Predictors of lithium response in bipolar disorder

Tighe

Mahon

Potash

2011

Therapeutic Advances in Chronic Disease

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While lithium is generally regarded as the first-line agent for patients with bipolar disorder, it does not work for everyone, which raises the question: can we predict who will be most likely to respond? In this paper, we review the most compelling clinical, biologic, and genetic predictors of lithium response in bipolar disorder. Among clinical factors, the strongest predictors of good response are fewer hospitalizations preceding treatment, an episodic course characterized by an illness pattern of mania followed by depression, and a later age at onset of bipolar disorder. While several biologic predictors have been studied, the results are preliminary and require replication with studies of larger patient samples over longer observation periods. Neuroimaging is a particularly promising method given that it might concurrently illuminate pathophysiologic underpinnings of bipolar disorder, the mechanism of action of lithium, and potential predictors of lithium response. The first genome-wide association study of lithium response was recently completed. No definitive results emerged, perhaps because the study was underpowered. With major new initiatives in progress aiming to identify genes and genetic variations associated with lithium response, there is much reason to be hopeful that clinically useful information might be generated within the next several years. This could ultimately translate into tests that could guide the choice of mood-stabilizing medication for patients. In addition, it might facilitate pharmacologic research aimed at developing newer, more effective medications that might act more quickly and yield fewer side effects.

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“…1,2 Some neuroimaging studies have reported findings suggestive of similar effects of Li in humans, [3][4][5][6][7] although the data continue to be limited and inconsistent. [8][9][10][11][12][13] Smaller hippocampal volumes are among the most replicated neuroimaging findings in patients with major depressive disorder compared with healthy controls.…”

Section: Introductionmentioning

confidence: 99%

“…Lithium treatment leads to increased hippocampal volumes reported in pro spective studies. 7 Lithiumexposed patients in retrospective studies have typically shown larger hippocampal volumes than unmedicated participants. 26,47,48 Thus, it is possible that hippocampal volume changes in patients with bipolar disorder are masked by exposure to putative neuroprotective effects of Li.…”

Section: Introductionmentioning

confidence: 99%

Smaller hippocampal volumes in patients with bipolar disorder are masked by exposure to lithium: a meta-analysis

Hájek

Kopeček

Höschl

et al. 2012

J Psychiatry Neurosci

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Bilateral hippocampal volume increases after long-term lithium treatment in patients with bipolar disorder: a longitudinal MRI study

Abstract: Consistent with preclinical literature supporting the neuroprotective effects of lithium, long-term treatment is associated with preservation of recollective memory function and increased hippocampal size in vivo.

Cited by 193 publications

References 89 publications

Amygdala and Hippocampal Volumes in Relatives of Patients with Bipolar Disorder: A High—Risk Study

Amygdala and Hippocampal Volumes in Relatives of Patients with Bipolar Disorder: A High—Risk Study

Predictors of lithium response in bipolar disorder

Smaller hippocampal volumes in patients with bipolar disorder are masked by exposure to lithium: a meta-analysis

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