Temporal influence of ascorbic acid dose on the endogenous formation of N-nitrosoproline and N-nitrosothiazolidine-4-carboxylic acid in humans

Helser, Michael A.; Hotchkiss, Joseph H.; Roe, Daphne A.

doi:10.1016/0955-2863(91)90087-l

Cited by 11 publications

(3 citation statements)

References 15 publications

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“…Previous studies have shown that vitamin C supplementation is capable of reducing urinary NOC formation [30,31]. Vitamin C supplementation was only capable of inhibiting a significant increase after consumption of a single bottle of BRJ, as was measured in urine.…”

Section: Discussionmentioning

confidence: 89%

“…Several studies are in alignment with our findings. Mirvish et al (1996) and Helser et al (1991) established that proline ingestion with simultaneous vitamin C supplementation resulted in a reduced formation of endogenous NPRO ( N -nitrosoproline), a non-carcinogenic NOC, after one day [30,31]. However, Vermeer et al showed that the mean NDMA excretion decreased after a couple days of consumption of a nitrate-rich diet and 1000 mg of vitamin C, which is in contrast to the findings of our study [24].…”

Section: Discussionmentioning

confidence: 99%

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Consumption of Nitrate-Rich Beetroot Juice with or without Vitamin C Supplementation Increases the Excretion of Urinary Nitrate, Nitrite, and N-nitroso Compounds in Humans

Berends

Berg

Guggeis

et al. 2019

IJMS

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Consumption of nitrate-rich beetroot juice (BRJ) by athletes induces a number of beneficial physiological health effects, which are linked to the formation of nitric oxide (NO) from nitrate. However, following a secondary pathway, NO may also lead to the formation of N-nitroso compounds (NOCs), which are known to be carcinogenic in 39 animal species. The extent of the formation of NOCs is modulated by various other dietary factors, such as vitamin C. The present study investigates the endogenous formation of NOCs after BRJ intake and the impact of vitamin C on urinary NOC excretion. In a randomized, controlled trial, 29 healthy recreationally active volunteers ingested BRJ with or without additional vitamin C supplements for one week. A significant increase of urinary apparent total N-nitroso Compounds (ATNC) was found after one dose (5 to 47 nmol/mmol: p < 0.0001) and a further increase was found after seven consecutive doses of BRJ (104 nmol/mmol: p < 0.0001). Vitamin C supplementation inhibited ATNC increase after one dose (16 compared to 72 nmol/mmol, p < 0.01), but not after seven daily doses. This is the first study that shows that BRJ supplementation leads to an increase in formation of potentially carcinogenic NOCs. In order to protect athlete’s health, it is therefore important to be cautious with chronic use of BRJ to enhance sports performances.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Consumption of Nitrate-Rich Beetroot Juice with or without Vitamin C Supplementation Increases the Excretion of Urinary Nitrate, Nitrite, and N-nitroso Compounds in Humans

Berends

Berg

Guggeis

et al. 2019

IJMS

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show abstract

“…Although the evidence that endogenously formed N-nitrosamines are involved in human cancers is far from conclusive, it is important to discover naturally occurring or synthetic compounds which can suppress or prevent the toxicity, mutagenicity, and carcinogenicity of N-nitrosamines. Several studies have quantified the inhibition of nitrosation by food components including ascorbic acid in vitro (Mirvish et al, 1983;Bartsch et al, 1988) and in vivo (Lin et al, 1986;Liu et al, 1986;Leaf et al, 1987;Mei et al, 1989;Helser et al, 1991Helser et al, , 1992. However, few authors have quantified the inhibition of N-nitrosamines effect by natural compounds present in fruits and vegetables.…”

Section: Introductionmentioning

confidence: 99%

Antimutagenic Effect of Fruit and Vegetable Ethanolic Extracts against N-Nitrosamines Evaluated by the Ames Test

Ikken

Morales

Martínez

et al. 1999

J. Agric. Food Chem.

113

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The inhibitory effect of nine fruit and vegetable ethanolic extracts against the mutagenicity of N-nitrosodimethylamine (NDMA), N-nitrosopyrrolidine (NPYR), N-nitrosodibutylamine (NDBA), and N-nitrosopiperidine (NPIP) was evaluated by means of the Ames test. Licorice ethanolic extract was the only one that showed an inhibitory effect (ranging from moderate to strong) against mutagenicity of all N-nitrosamines tested. This ethanolic extract showed the greatest inhibition effect against NPIP (72%), NDMA (45%), and NPYR (39%). The greatest inhibition effect (51%) of the mutagenicity of NDBA was shown by kiwi ethanolic extract. Vegetable and fruit ethanolic extracts that exhibited an antimutagenic effect (at the range 50-2000 microg/plate), in decreasing order, against NDMA and NPYR were as follows: licorice > kiwi > carrot and licorice > broccoli > pineapple > kiwi, respectively. Decreasing orders against NDBA and NPIP were, respectively, kiwi > onion > licorice = garlic > green pepper > carrot and licorice > garlic > pineapple > carrot.

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Quantitative relationship between oral nitrate-reducing activity and the endogenous formation of N-nitrosoamino acids in humans

Shapiro

Hotchkiss

Roe

1991

Food and Chemical Toxicology

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Temporal influence of ascorbic acid dose on the endogenous formation of N-nitrosoproline and N-nitrosothiazolidine-4-carboxylic acid in humans

Cited by 11 publications

References 15 publications

Consumption of Nitrate-Rich Beetroot Juice with or without Vitamin C Supplementation Increases the Excretion of Urinary Nitrate, Nitrite, and N-nitroso Compounds in Humans

Consumption of Nitrate-Rich Beetroot Juice with or without Vitamin C Supplementation Increases the Excretion of Urinary Nitrate, Nitrite, and N-nitroso Compounds in Humans

Antimutagenic Effect of Fruit and Vegetable Ethanolic Extracts against N-Nitrosamines Evaluated by the Ames Test

Quantitative relationship between oral nitrate-reducing activity and the endogenous formation of N-nitrosoamino acids in humans

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