Antimutagenic Effect of Fruit and Vegetable Ethanolic Extracts against <i>N</i>-Nitrosamines Evaluated by the Ames Test

Ikken, Youssef; Morales, Paloma; Martínez, A.; Marín, María; Haza, and Ana Isabel; Cambero, M.I.

doi:10.1021/jf990166n

Cited by 113 publications

(70 citation statements)

References 67 publications

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“…Of 119 drugs still extracted from plants and used globally, 74% were discovered during an attempt to identify the chemical substances amongst medicinal plants responsible for combating human diseases (Farnsworth, 1990). More importantly, some of the plants natural products have various biological activities such as anti-inflammatory, anticarcinogenic and anti-atherosclerotic, antibacterial, antifungal, antiviral, antimutagenic and antiallergic activities (Ikken et al, 1999;Noguchi et al, 1999;Mishra et al, 2009). These biological activities may be associated with their antioxidant activity (Chung et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Antifungal Activity of Selected Medicinal Plant Extracts Against Phytopathogenic Fungi.

Mahlo¹,

Chauke²,

McGaw³

et al. 2016

Afr J Tradit Complement Altern Med

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Background: Medicinal plants are used by many ethnic groups as a source of medicine for the treatment of various ailments in both humans and domestic animals. These plants produce secondary metabolites that have antimicrobial properties, thus screening of medicinal plants provide another alternative for producing chemical fungicides that are relatively non-toxic and cost-effective. Materials and methods: Leaf extracts of selected South African plant species (Bucida buceras, Breonadia salicina, Harpephyllum caffrum, Olinia ventosa, Vangueria infausta and Xylotheca kraussiana) were investigated for activity against selected phytopathogenic fungi (Aspergillus niger, Aspergillus parasiticus, Colletotricum gloeosporioides, Penicillium janthinellum, P. expansum, Trichoderma harzianum and Fusarium oxysporum). These plant fungal pathogens causes major economic losses in fruit industry such as blue rot on nectaries and postharvest disease in citrus. Plant species were selected from 600 evaluated inter alia, against two animal fungal pathogens (Candida albicans and Cryptococcus neoformans). Antioxidant activity of the selected plant extracts were investigated using a qualitative assay (2, 2-diphenyl-1-picrylhydrazyl (DPPH)). Bioautography assay was used to determine the number of antifungal compounds in plant extracts. Results: All plant extracts were active against the selected plant phytopathogenic fungi. Moreover, Bucida buceras had the best antifungal activity against four of the fungi, with minimum inhibitory concentration (MIC) values as low as 0.02 mg/ml and 0.08 mg/ml against P. expansum, P. janthinellum, T. harzianum and F. oxysporum. The plant extracts of five plant species did not possess strong antioxidant activity. However, methanol extract of X. kraussiana was the most active radical scavenger in the DPPH assay amongst the six medicinal plants screened. No antifungal compounds were observed in some of the plant extracts with good antifungal activity as shown in the microdilution assay, indicating possible synergism between the separated metabolites. Conclusion: The results showed that acetone was the best extractant. Furthermore, our findings also confirm the traditional use of Breonadia salicina and demonstrate the potential value of developing biopesticides from plants.

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Section: Introductionmentioning

confidence: 99%

Antioxidant and Antifungal Activity of Selected Medicinal Plant Extracts Against Phytopathogenic Fungi.

Mahlo¹,

Chauke²,

McGaw³

et al. 2016

Afr J Tradit Complement Altern Med

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“…Extracts of Glycyrrhiza, and glycyrrhizinic acid and its glucoside (glycyrrhetinic acid) derived from Glycyrrhiza have been reported to show antimutagenicity (28)(29)(30)(31)(32). They inhibit the mutagenicity against indirect acting N-nitrosamines (28,29), benzo(a)pyrene (30), 2-amino‰uorene (30) and a‰atoxin B1 (30,31) in S. typhimurium TA100 and TA98, direct acting N-methyl-N?-nitro-N-nitrosoguanidine and ethyl methanesulfonate in S. typhimurium TA100 (31).…”

Section: Discussionmentioning

confidence: 99%

“…They inhibit the mutagenicity against indirect acting N-nitrosamines (28,29), benzo(a)pyrene (30), 2-amino‰uorene (30) and a‰atoxin B1 (30,31) in S. typhimurium TA100 and TA98, direct acting N-methyl-N?-nitro-N-nitrosoguanidine and ethyl methanesulfonate in S. typhimurium TA100 (31).…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Antimutagenic Effects of Aqueous Extracts from Herbal Medicines against N-Alkyl-N-nitrosoureas-induced Mutagenicity Using the umu Test

Inami

Takada

Itoh

et al. 2014

Genes and Environment

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“…The chemo-preventive effects of these natural dietary compounds in vegetables and fruits have involved various mechanisms including being an antioxidant, exhibiting anti-inflammatory activity, inducing phase II enzymes, and apoptosis [3]. Therefore, the regular intake of plant containing antioxidative and anti-inflammatory agents reduces the risk of cancer development [4]. It has now accepted that inflammation plays a crucial role in chronic inflammatory diseases and the cancer development [5,6].…”

Section: Introductionmentioning

confidence: 99%

Some Phytochemicals and Anti-inflammation Effect of Juice from <i>Tiliacora triandra</i> Leaves

Weerawatanakorn¹,

Rojsuntornkitti²,

Pan³

et al. 2018

JFNR

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Tiliacora triandra (TT), native to Southeast Asia, has been widely used as folk medicine and in cuisines in many areas. Although little scientific evidence supports the health benefits of TT leaves, the juice extracted from TT leaves has become popular for consumers among all socioeconomic classes. Thus, this study aims to evaluate the phytochemical profile and anti-inflammatory properties of juice extracted from TT leaves. The result revealed that, the highest total phenolic contents (199.92 mg GAE/g), total flavonoid contents (29.76 mg RUE/g), and extraction yield (61.2%) of the lyophilized TT leaves juice powder were found in the solvent mixture of ethanol, water, and acetone extracts. The highest DPPH radical scavenging value (90.95%) of the lyophilized TT leaves juice powder was found in hot water extract. By HPLC analysis, total phenolic compounds of the lyophilized TT leaves juice powder was 3,938.1 mg/kg. Tannic acid, gallic acid, and rutin are the major phenolic compound and the juice is a rich source of chlorophyll compound (3,551.6 mg/kg). The lyophilized TT leaves juice down-regulated the induction of inflammatory iNOS and COX-2 proteins in LPS-stimulated macrophages. The results suggest that intake of TT leaves juice, providing various phenolic and chlorophyll compounds, has great potential for reducing the inflammatory process.

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Antimutagenic Effect of Fruit and Vegetable Ethanolic Extracts against N-Nitrosamines Evaluated by the Ames Test

Cited by 113 publications

References 67 publications

Antioxidant and Antifungal Activity of Selected Medicinal Plant Extracts Against Phytopathogenic Fungi.

Antioxidant and Antifungal Activity of Selected Medicinal Plant Extracts Against Phytopathogenic Fungi.

Assessment of the Antimutagenic Effects of Aqueous Extracts from Herbal Medicines against N-Alkyl-N-nitrosoureas-induced Mutagenicity Using the umu Test

Some Phytochemicals and Anti-inflammation Effect of Juice from <i>Tiliacora triandra</i> Leaves

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