Quantitative relationship between oral nitrate-reducing activity and the endogenous formation of N-nitrosoamino acids in humans

Shapiro, Kenneth B.; Hotchkiss, Joseph H.; Roe, Daphne A.

doi:10.1016/0278-6915(91)90183-8

Cited by 77 publications

(54 citation statements)

References 18 publications

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“…The formation of endogenous nitrosamines in the oral cavity by nitrate-reducing bacteria is promoted by poor oral hygiene and periodontal disease, as well as by tobacco use and certain dietary factors [60][61][62]. Tooth loss resulting from poor oral hygiene may also contribute to greater nitrosamine production [40].…”

Section: Possible Explanations and Biological Mechanismsmentioning

confidence: 99%

A review of the relationship between tooth loss, periodontal disease, and cancer

Meyer

Joshipura

Giovannucci

et al. 2008

Cancer Causes Control

303

234

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Recent studies have investigated the association between periodontal disease, tooth loss, and several systemic diseases including cancer, cardiovascular disease, and preterm birth. Periodontal disease, a chronic inflammatory condition, is highly prevalent in adult populations around the world, and may be preventable. Estimates of prevalence vary between races and geographic regions, with a marked increase in the occurrence of periodontal disease with advancing age. Worldwide estimates for the prevalence of severe periodontal disease generally range from 10 to 15%. The relationship between oral health and cancer has been examined for a number of specific cancer sites. Several studies have reported associations between periodontal disease or tooth loss and risk of oral, upper gastrointestinal, lung, and pancreatic cancer in different populations. In a number of studies, these associations persisted after adjustment for major risk factors, including cigarette smoking and socioeconomic status. This review provides a summary of these findings, discusses possible biological mechanisms involved, and raises methodological issues related to studying these relationships.

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Section: Possible Explanations and Biological Mechanismsmentioning

confidence: 99%

A review of the relationship between tooth loss, periodontal disease, and cancer

Meyer

Joshipura

Giovannucci

et al. 2008

Cancer Causes Control

303

234

View full text Add to dashboard Cite

show abstract

“…As previously reported, increased yeast infections and conversions from Gram-negative to Gram-positive bacteria has been demonstrated in smokers (99,101,102). However, oral bacteria may activate the nitrosamines from tobacco smoking to carcinogenic adducts by forming hydroxylated products (103)(104)(105).…”

Section: Interactions Between Alcohol Consumption and The Correspondimentioning

confidence: 66%

Alcohol consumption and corresponding factors: A novel perspective on the risk factors of esophageal cancer

2016

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Abstract. Esophageal cancer is the eighth most common type of cancer in the world, and the sixth most common cause of mortality from cancer. Alcohol consumption is the major risk factor for esophageal cancer, due to the worldwide prevalence and high carcinogenicity of the ethanol metabolite. In epidemiological studies, the efficiency of alcohol intake to enhance the risk of esophageal cancer is altered by daily ethanol consumption, type of alcoholic beverages ingested, time since quitting drinking, age of drinking initiation, differences in population and subtypes of esophageal cancer. Corresponding factors, including gene polymorphisms, tobacco smoking, oral microorganisms and folate deficiency, reveal a synergistic effect in concurrent alcohol users that may lead to an increased risk of developing esophageal cancer. Consequently, esophageal cancer prevention involves multiple aspects, including quitting drinking and smoking, maintaining an adequate oral health and ingesting adequate quantities of folate, particularly in genetically high-risk populations.

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“…The ionic strength was kept constant (I = 1.00 M) by adding the appropriate amount of NaClO 4 . The reactions were performed by mixing in the quartz cell the appropriate amounts of FDSH 2 Cl 2 , HClO 4 , NaNO 2 , NaSCN or, alternatively, NaCl and NaBr solutions.…”

Section: Kinetic Methodsmentioning

confidence: 99%

“…4 Increasing attention is being paid to the chemistry of nitrosamines owing to the toxicity 5 and carcinogenic, 6 mutagenic, 7 and teratogenic 8 properties of these compounds. In more recent times, since the discovery of the amazing biological properties of nitric oxide there has been a large interest in the chemistry of S-nitrosothiols, these can act as possible vasodilators, anti-platelet aggregation agents etc.…”

Section: Introductionmentioning

confidence: 99%

Kinetic study of an autocatalytic reaction: nitrosation of formamidine disulfide

et al. 2008

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The reaction kinetics for the acid nitrosation of formamidine disulfide (FDS) show an autocatalytic behavior that arises from the fact that the thiocyanate ion formed as a product acts as a powerful catalyst for the nitrosation reaction. In the presence of added nucleophiles the suppression of the autocatalytic route results from competition for the nitrous acid between the added halides and the thiocyanate anion, which is formed as a reaction product. Analysis of the kinetic data enabled extraction of the bimolecular rate constants, Kinetic results are consistent with the attack on the nitrosating agent as the rate limiting step, i.e., the nitrosation of FDS behaves in a similar manner to the nitrosation of an amine. Rather different behavior is found for other substrates with an imino moiety adjacent to an amino nitrogen, such as the guanidines, which react by a mechanism in which the rate limiting step is the reorganization of the nitrosated substrate.

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Quantitative relationship between oral nitrate-reducing activity and the endogenous formation of N-nitrosoamino acids in humans

Cited by 77 publications

References 18 publications

A review of the relationship between tooth loss, periodontal disease, and cancer

A review of the relationship between tooth loss, periodontal disease, and cancer

Alcohol consumption and corresponding factors: A novel perspective on the risk factors of esophageal cancer

Kinetic study of an autocatalytic reaction: nitrosation of formamidine disulfide

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