Alcohol consumption and corresponding factors: A novel perspective on the risk factors of esophageal cancer

Qiao, Peng; Chen, Hui; Huo, Jirong

doi:10.3892/ol.2016.4401

Cited by 34 publications

(29 citation statements)

References 125 publications

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“…People with a mutated ALDH2-2 allele accumulate acetaldehyde and, if they ingest alcohol, they are exposed to a much higher risk of alcohol-mediated cancers than people with a wildtype allele. ALDH2-2 mutations occur commonly in (East) Asian countries [5,17]. In Japan for example, up to 40% of the population are heterogenous for the ALDH2 gene and are therefore at a higher risk of alcohol-related upper digestive tract cancers [18].…”

Section: Genetic Susceptibilitymentioning

confidence: 99%

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Alcohol Use and Gastrointestinal Cancer Risk

Scherübl¹

2020

Visc Med

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Background: Alcohol use is an important and potentially modifiable risk factor for gastrointestinal cancers. The more and the longer a person drinks, the higher the risk of cancer becomes. Even modest use of alcohol may increase cancer risk; 100 g of alcohol per week or less is currently considered to be the limit of low-risk use. Gastrointestinal Cancer Risk: Alcohol is causally associated with oesophageal squamous cell cancer, gastric cancer, hepatocellular carcinoma, colorectal cancer, and most likely also with pancreatic cancer. Alcohol when combined with tobacco smoking or excess body weight can act synergistically to cause gastrointestinal cancer. Exposure to alcohol may have contributed to the recent incidence increases of early-onset gastrointestinal cancers in some Western countries. Conclusions: People with longterm risky alcohol use should be encouraged to join cancer screening programmes. Alcohol cessation appears to be effective in reducing the alcohol-induced, increased cancer risk.

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Section: Genetic Susceptibilitymentioning

confidence: 99%

“…The list of alcohol-associated cancers is still growing. Even modest use of alcohol may increase cancer risk, in particular when combined with either tobacco smoking or excess body weight [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Alcohol Use and Gastrointestinal Cancer Risk

Scherübl¹

2020

Visc Med

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“…Because excess alcohol consumption poses a significant global public health issue, there have been efforts to minimize exposure to alcohol, which has important implications for ESCC prevention and alcohol abuse. 2,3 However, variation in alcohol consumption alone does not explain the differing incidence between regions at high and low risk of ESCC. Other etiological factors associated with ESCC should be further explored.…”

Section: Introductionmentioning

confidence: 99%

Alcohol Intake Interacts with Functional Genetic Polymorphisms of Aldehyde Dehydrogenase (ALDH2) and Alcohol Dehydrogenase (ADH) to Increase Esophageal Squamous Cell Cancer Risk

Suo

Yang

Yuan

et al. 2019

Journal of Thoracic Oncology

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Introduction: Studies have reported alcohol consumption and genetic variants as major contributing factors for esophageal squamous cell carcinoma (ESCC). However, the complicated interactions between alcohol and genetic factors involved in alcohol metabolism have not been well elucidated with respect to augmented risk of ESCC. Alcohol Intake, ALDH2, ADH, and ESCC Risk 715 a Rs671 genotype AA is not included because of insufficient samples size.bProportion of drinkers in controls among different genotypes: of the controls with rs671 genotype GG, 458 were never-drinkers and 545 (54.3%) were drinkers, and of the controls with rs671 genotype AG, 426 were never-drinkers and 132 (23.7%) were drinkers.ALDH2, aldehyde dehydrogenase 2 family member gene; CI, confidence interval; aOR, adjusted OR.

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“…There is no final consensus on the list of risk factors for oesophageal cancer, but in many studies smoking and alcohol drinking showed a strong association with squamous cell carcinoma [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Oesophageal Cancer Magnitude and Presentation in Ethiopia

Wondimagegnehu

Hirpa

Abaya

et al. 2019

Preprint

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Background Although oesophageal cancer is a public health problem in Ethiopia, there are limited data on the magnitude and distribution of the disease in the country. The aim of this study is to assess the magnitude, socio-demographic and clinical characteristics of oesophageal cancer patients in selected referral hospitals of Ethiopia.Methods A retrospective document review was employed in ten referral hospitals in different regions of Ethiopia. Data were extracted from clinical care records of all clinically and pathologically confirmed oesophageal cancer patients who were diagnosed and treated in those hospitals from 2012 - 2017. A structured data extraction tool was used to collect important variables. Descriptive statistics such as median, interquartile range (IQR) and percentages were computed to describe the regional and national distribution of the disease.Results Over the past six years, a total of 777 oesophageal cancer cases were identified and the median age of these patients was 55 years with IQR of 19. More than half 428 (55.1%) of the cases were males and majority of them were reported from Oromia and Somali regional states with 388 (49.9%) and 202 (25.9%) respectively. The highest number of oesophageal cancer cases were recorded in 2016 with a total number of 185 (23.8%) while the lowest 98 (12.6%) was in 2012. Eighty percent of oesophageal cancer cases were diagnosed at late stage of the disease. More than one-fourth 210 (27.0%) of patients were operated with the majority 156 (74.3%) to insert a feeding tube followed by trans-hiatal oesophagostomy 23 (10.9%). Of the 118 results analysed, squamous cell carcinoma and adeno carcinoma were the predominant histologic type with 67(56.7%), and 43(36.4%) respectively. One fourth 194 (25.0%) of the patients were alive and more than two third 557 (71.7%) patients’ current status were unknown at the time of the review.Conclusions In referral hospitals of Ethiopia, many oesophageal cancer patients came at late stage of the disease and needed palliative care measures. The number of patients seen in Oromia and Somali region hospitals by far exceeds hospitals of the other regions thus postulating possibly unique risk factors in those geographic areas.

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Alcohol consumption and corresponding factors: A novel perspective on the risk factors of esophageal cancer

Cited by 34 publications

References 125 publications

Alcohol Use and Gastrointestinal Cancer Risk

Alcohol Use and Gastrointestinal Cancer Risk

Alcohol Intake Interacts with Functional Genetic Polymorphisms of Aldehyde Dehydrogenase (ALDH2) and Alcohol Dehydrogenase (ADH) to Increase Esophageal Squamous Cell Cancer Risk

Oesophageal Cancer Magnitude and Presentation in Ethiopia

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