Alcohol Intake Interacts with Functional Genetic Polymorphisms of Aldehyde Dehydrogenase (ALDH2) and Alcohol Dehydrogenase (ADH) to Increase Esophageal Squamous Cell Cancer Risk

Suo, Chen; Yang, Yajun; Yuan, Ziyu; Zhang, Tiejun; Yang, Xiaorong; Qing, Tao; Gao, Pei; Shi, Leming; Fan, Min; Cheng, Hongwei; Lü, Ming; Jin, Li; Chen, Xingdong; Ye, Weimin

doi:10.1016/j.jtho.2018.12.023

Cited by 40 publications

(33 citation statements)

References 25 publications

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“…The research design and flow of subject recruitment have been described in detail previously ( 17–19 ). In brief, we performed a population-based, case-control study from 2010–2014 in Taixing, Jiangsu province, China, where the incidence of ESCC is high ( 11 ).…”

Section: Methodsmentioning

confidence: 99%

Associations Between Gastric Atrophy and Its Interaction With Poor Oral Health and the Risk for Esophageal Squamous Cell Carcinoma in a High-Risk Region of China: A Population-Based Case-Control Study

Ekheden¹,

Yang²,

Chen³

et al. 2020

American Journal of Epidemiology

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Abstract Previous findings concerning gastric atrophy as a potential risk factor for esophageal squamous cell carcinoma (ESCC) have been inconsistent. We aimed to test whether gastric atrophy and, further, its interaction with poor oral health elevated the risk of ESCC in a high-risk region of China. Our population-based case-control study in Taixing, China (2010–2014), recruited cases from local hospitals and the local cancer registry. Controls were selected randomly from the local population registry. Ultimately, 1,210 cases and 1,978 controls answered questionnaires and provided blood samples for assay of pepsinogens. Unconditional logistic regression models were used to estimate odds ratios and 95% confidence intervals. Gastric atrophy (defined as a serum level of pepsinogen I of <55 μg/L) was associated with an increased risk for ESCC (odds ratio = 1.61; 95% confidence interval: 1.33, 1.96), even after full adjustment for potential confounding factors. In addition, suggestion of an additive interaction between gastric atrophy and poor oral health was observed (relative excess risk due to interaction = 1.28, 95% confidence interval: 0.39, 2.18). We conclude that gastric atrophy appears to be a risk factor for ESCC in a high-risk region of China, and there is a suggested additive interaction with poor oral health that increases this risk even further.

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Section: Methodsmentioning

confidence: 99%

Associations Between Gastric Atrophy and Its Interaction With Poor Oral Health and the Risk for Esophageal Squamous Cell Carcinoma in a High-Risk Region of China: A Population-Based Case-Control Study

Ekheden¹,

Yang²,

Chen³

et al. 2020

American Journal of Epidemiology

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“…Interestingly, Wu et al reported that consumption of alcohol only increased the risk of ESCC in males but not in females ( 36 ), as supported by another study that indicated that only males who drank alcohol had a 2.2-fold (95% CI: 1.79–2.70) higher ESCC risk ( 37 ). Mechanistically, a case-control study that enrolled 1,190 patients and 1,883 controls revealed that alcohol consumption could interact with aldehyde dehydrogenase and alcohol dehydrogenase (ADH), resulting in a markedly elevated ESCC incidence ( 38 ).…”

Section: Risk Factors Of Ecmentioning

confidence: 99%

Understanding Esophageal Cancer: The Challenges and Opportunities for the Next Decade

et al. 2020

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Esophageal cancer (EC) is the seventh most common cancer worldwide with over 570,000 new cases annually. In China, the incidence of EC is particularly high where approximately 90% of cases are defined as esophageal squamous cell carcinoma (ESCC). Although various risk factors have been identified, the knowledge of genetic drivers for ESCC is still limited due to high mutational loading of the cancer and lack of appropriate EC models, resulting in inadequate treatment choices for EC patients. Currently, surgery, chemotherapy, radiation, and limited targeted therapy options can only bring dismal survival advantages; thus, the prognosis for ESCC is very poor. However, cancer immunotherapy has unleashed a new era of cancer treatment with extraordinary therapeutic benefits for cancer patients, including EC patients. This review discusses the latest understanding of the risk factors and clinical rational for EC treatment and provides accumulated information, which describes the ongoing development of immunotherapy for EC with a specific emphasis on ESCC, the most prevalent EC subtype in the Chinese population.

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“…Also the adverse role of loss-of-functional ADH and ALDH variants will increase in alcohol drinkers. Third, the mechanism of tumorigenesis may not be same with and without a family history of the esophageal cancer [52,53].…”

Section: Adhmentioning

confidence: 99%

Genetic Polymorphism and Alcohol Metabolism

Jain¹,

Sedha²,

Mishra³

2020

The Recent Topics in Genetic Polymorphisms

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Throughout the world, human population experiment with alcohol, result into short-and long-term consequences including increased risk of accidental injuries, risky sexual behavior and lower education attainment. Due to polymorphism in the gene whose product enzymes are responsible for alcohol metabolism, serious health consequences including liver cirrhosis and hepatocarcinoma can occur. Enzyme alcohol dehydrogenase, CYP450 and catalase are alcohol metabolizing enzymes. Polymorphism in any one or all of the enzymes will result in defective alcohol metabolism and acetaldehyde accumulation cause serious health problems. This article mainly focuses on the consequences of alcohol consumption at genetic level that ultimately affect alcohol metabolism resulting in various health disorders.

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Alcohol Intake Interacts with Functional Genetic Polymorphisms of Aldehyde Dehydrogenase (ALDH2) and Alcohol Dehydrogenase (ADH) to Increase Esophageal Squamous Cell Cancer Risk

Cited by 40 publications

References 25 publications

Associations Between Gastric Atrophy and Its Interaction With Poor Oral Health and the Risk for Esophageal Squamous Cell Carcinoma in a High-Risk Region of China: A Population-Based Case-Control Study

Associations Between Gastric Atrophy and Its Interaction With Poor Oral Health and the Risk for Esophageal Squamous Cell Carcinoma in a High-Risk Region of China: A Population-Based Case-Control Study

Understanding Esophageal Cancer: The Challenges and Opportunities for the Next Decade

Genetic Polymorphism and Alcohol Metabolism

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