Telomere length was similar in school‐age children with bronchopulmonary dysplasia and allergic asthma

Henckel, Ewa; Svenson, Ulrika; Nordlund, Björn; Broström, Eva Berggren; Hedlin, Gunilla; Degerman, Sofie; Bohlin, Kajsa

doi:10.1111/apa.14294

Cited by 11 publications

(16 citation statements)

References 31 publications

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“…Moreover, it has been shown that the rate of telomere shortening is most pronounced in the early years of life following birth and that this rate of attrition declines in young adulthood and reduces further still in older individuals [29,30,31,32,34]. Despite the relatively earlier onset of telomere shortening in preterm infants in comparison to term born infants overall telomere length does not appear to be significantly shortened at term equivalent age [49] or in early childhood [61]. Interestingly however, a number of studies have highlighted that telomere attrition rate in adults is most prominent in those with higher telomere length at baseline [59,62,63].…”

Section: Telomere Homeostasis Throughout a Life-timementioning

confidence: 99%

Telomere Biology and Human Phenotype

Turner

Vasu

Griffin

2019

Cells

266

223

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Telomeres are nucleoprotein structures that cap the end of each chromosome arm and function to maintain genome stability. The length of telomeres is known to shorten with each cell division and it is well-established that telomere attrition is related to replicative capacity in vitro. Moreover, telomere loss is also correlated with the process of aging in vivo. In this review, we discuss the mechanisms that lead to telomere shortening and summarise telomere homeostasis in humans throughout a lifetime. In addition, we discuss the available evidence that shows that telomere shortening is related to human aging and the onset of age-related disease.

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Section: Telomere Homeostasis Throughout a Life-timementioning

confidence: 99%

Telomere Biology and Human Phenotype

Turner

Vasu

Griffin

2019

Cells

266

223

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“…Telomere shortening may not only explain the limited proliferation ability of cells in asthmatic patients, but also highly correlated to the clinical features and severity of asthma. For example, telomere shortening in bronchial fibroblasts was associated with airway hyperresponsiveness (Hadj Salem et al, 2015) and lower forced expiratory flow (Henckel et al, 2018). Furthermore, shorter telomere served as a biomarker of life-course-persistent asthma and was linked to eosinophilic inflammation (Belsky et al, 2014).…”

Section: Telomere Shorteningmentioning

confidence: 99%

Potential Role of Cellular Senescence in Asthma

Wang

Yang

et al. 2020

Front. Cell Dev. Biol.

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Cellular senescence is a complicated process featured by irreversible cell cycle arrest and senescence-associated secreted phenotype (SASP), resulting in accumulation of senescent cells, and low-grade inflammation. Cellular senescence not only occurs during the natural aging of normal cells, but also can be accelerated by various pathological factors. Cumulative studies have shown the role of cellular senescence in the pathogenesis of chronic lung diseases including chronic obstructive pulmonary diseases (COPD) and idiopathic pulmonary fibrosis (IPF) by promoting airway inflammation and airway remodeling. Recently, great interest has been raised in the involvement of cellular senescence in asthma. Limited but valuable data has indicated accelerating cellular senescence in asthma. This review will compile current findings regarding the underlying relationship between cellular senescence and asthma, mainly through discussing the potential mechanisms of cellular senescence in asthma, the impact of senescent cells on the pathobiology of asthma, and the efficiency and feasibility of using anti-aging therapies in asthmatic patients.

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“…The AOS and control groups were composed of 80 cases with 43 males and 37 females, and aged 3–12 years. Age is associated with the risk of allergic asthma ( 32 , 33 ). In our study, age distribution (5-7, 8-10, and 11-12) was similar between the two groups ( P > 0.05).…”

Section: Resultsmentioning

confidence: 99%

Astragalus Oral Solution Ameliorates Allergic Asthma in Children by Regulating Relative Contents of CD4+CD25highCD127low Treg Cells

2018

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Objective: To explore the effects of Astragalus oral solution (AOS) on allergic asthma in children by investigating relative contents of CD4+CD25highCD127low Treg cells.Methods: The contents of Astragaloside A in AOS were detected by using HPLC. Eighty children with allergic asthma were recruited from February 2016 to June 2017, and randomly assigned into the control group (received placebo, 0.1% quinine chloride in deionized water, daily) and the AOS group (received 10 mL AOS daily). After 6-month treatment, therapeutic results were compared between the two groups. Serum levels of IL-10 and TGF-beta, Th1 cytokines (IL-2 and IFN-γ), and Th2 cytokines (IL-4 and IL-6) were measured by using ELISA kits. Relative contents of CD4+CD25highCD127low Treg cells were determined by using flow cytometry.Results: Astragaloside A was the main ingredient of AOS with 0.216 ± 0.027 mg/mL from six-batch samples. After 6-month therapy, the AOS group showed improved forced expiratory volume in 1 s (FEV1) and the Pediatric Asthma Quality of Life Questionnaire (PAQLQ) scores compared with the control group (P < 0.05). Serum level of IL-10 was higher and the levels of TGF-beta, Th1 cytokines (IL-2 and IFN-γ), and Th2 cytokines (IL-4 and IL-6) were lower in the AOS group than in the control group (P < 0.05). AOS treatment increased the percentage of gated CD4+ T cells, CD4+CD25+ T cells, CD4+CD25high Treg cells, CD4+CD25+FoxP3+ Treg cells and CD4+CD25highCD127low Treg cells when compared with the control group (P < 0.05).Conclusions: Astragaloside A was the main component of AOS, and AOS ameliorated allergic asthma in children by regulating relative contents of CD4+CD25highCD127low Treg cells.

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Telomere length was similar in school‐age children with bronchopulmonary dysplasia and allergic asthma

Abstract: Telomere length was similar in 10-year-old children born preterm with a history of BPD and term born children with allergic asthma. However, impaired lung function and male gender were associated with short telomeres.

Cited by 11 publications

References 31 publications

Telomere Biology and Human Phenotype

Telomere Biology and Human Phenotype

Potential Role of Cellular Senescence in Asthma

Astragalus Oral Solution Ameliorates Allergic Asthma in Children by Regulating Relative Contents of CD4+CD25highCD127low Treg Cells

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