Herein, alkoxylation chemistry is introduced as a “one‐stone‐three‐birds” solution for exploring a new family of highly‐fluorescent octupolar 2D‐conjugated organic polymers/frameworks (OCOPs/OCOFs) combining far‐red emission, high fluorescence quantum yield (QY), and strong two‐photon absorption (TPA). Both alkoxy‐substituted OCOP and OCOF comprising acrylonitrile‐bridged strongly‐coupled donor3‐(acceptor core) chromophores densely packed in either disordered or ordered forms, exhibit significantly redshifted emission. They produce high QY of 22.2% and 27.8% in tetrahydrofuran, large TPA cross section of 600 and 1124 GM, and 2–3 folds and 15–30 folds that of non‐alkoxylate amorphous counterpart respectively. Combined theoretical and experimental studies reveal unique “one‐stone‐three‐birds” role of the alkoxylation in realizing red‐shifted‐emission, improved QY and TPA enabled by inducing steric hindrance effect for weakened π–π stacking, and triggering p–π conjugation effect for electronically engineering octupolar chromophores, while the crystalline engineering enables enforced coplanarity conformation and improved π–electron delocalization for further improved QY and TPA. The robust and biocompatible pentoxy‐substituted polymer can be used not only as metal‐free red‐emissive phosphor for efficient warm white light‐emitting diodes, but also as efficient two‐photon fluorescence probes for bio‐imaging.
Cellular senescence is a complicated process featured by irreversible cell cycle arrest and senescence-associated secreted phenotype (SASP), resulting in accumulation of senescent cells, and low-grade inflammation. Cellular senescence not only occurs during the natural aging of normal cells, but also can be accelerated by various pathological factors. Cumulative studies have shown the role of cellular senescence in the pathogenesis of chronic lung diseases including chronic obstructive pulmonary diseases (COPD) and idiopathic pulmonary fibrosis (IPF) by promoting airway inflammation and airway remodeling. Recently, great interest has been raised in the involvement of cellular senescence in asthma. Limited but valuable data has indicated accelerating cellular senescence in asthma. This review will compile current findings regarding the underlying relationship between cellular senescence and asthma, mainly through discussing the potential mechanisms of cellular senescence in asthma, the impact of senescent cells on the pathobiology of asthma, and the efficiency and feasibility of using anti-aging therapies in asthmatic patients.
Delayed neutrophil apoptosis has been proved to be closely associated with acute lung injury. Bcl-2 inhibitor, venetoclax, can improve the clinical outcome of acute lung injury based on its pro-apoptosis...
Bacteria-induced acute lung injury (ALI) is associated with a high mortality rate due to the lack of an effective treatment. Patients often rely on supportive care such as low tidal...
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