Nanomedicine to advance the treatment of bacteria-induced acute lung injury

Su, Ruonan; Zhang, Jiabin; Wang, Haixia; Luo, Yun; Chan, Hon Fai; Tao, Yu; Chen, Zhuang‐Gui; Li, Mingqiang

doi:10.1039/d1tb01770e

Cited by 7 publications

(5 citation statements)

References 164 publications

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“…FH and FJH cannot infiltrate completely into the intact alveolae during blood circulation, but they can be quickly accumulated in the alveolar air space when the permeability of the alveolarcapillary barrier vessel is dramatically increased in the ALI mouse model. 4,44 Furthermore, the cationic group enables lung retention of FH and FJH through bonding with the negatively charged protein on the surface of the alveolar and capillary basement membrane. 36 As expected, the fluorescence imaging of the dissected main organs also showed that FH and FJH can accumulate in the lungs (Figure 1e,f).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

De Novo Design of Activatable Photoacoustic/Fluorescent Probes for Imaging Acute Lung Injury In Vivo

et al. 2022

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Effective monitoring of the physiological progression of acute lung injury (ALI) in real time is crucial for early theranostics to reduce its high mortality. In particular, activatable fluorescence and photoacoustic molecule probes have attracted attention to assess ALI by detecting related indicators. However, the existing fluorophores often encounter issues of low retention in the lungs and slow clearance from the body, which compromise the probe’s actual capability for in situ imaging by intravenous injection in vivo. Herein, a novel near-infrared hemicyanines fluorophore (FJH) bearing a quaternary ammonium group was first developed by combining with the rational design and screening strategy. The properties of good hydrophilicity and blood circulation effectively enable FJH accumulation for lung imaging. Inspired by the high retention efficiency, the probe FJH-C that turns on fluorescence and photoacoustic signals in response to the ALI indicator (esterase) was subsequently synthesized. Notably, the probe FJH-C successfully achieved the selectivity and sensitivity toward esterase in vitro and in living cells. More importantly, FJH-C can be further used to assess lipopolysaccharides and silica-induced ALI through the desired fluo-photoacoustic signal. Therefore, this study not only shows the first activatable probe for real-time imaging of lung function but also highlights the fluorophore structure with high lung retention. It is believed that FJH and FJH-C can serve as an efficient platform to reveal the pathological progression of other lung diseases for early diagnosis and medical intervention.

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Section: ■ Results and Discussionmentioning

confidence: 99%

De Novo Design of Activatable Photoacoustic/Fluorescent Probes for Imaging Acute Lung Injury In Vivo

et al. 2022

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“…Exposure of lung surface to air pollution, micro-organisms, occupational chemicals, and dust often leads to chronic or acute lung disorders. 144 Idiopathic pulmonary fibrosis (IPF) is an incurable lung disease with high mortality rate, which manifests as the formation of scar tissues and loss of the ability to exchange gases. 145,146 Recently, cell-free treatment based on stem cell secretome has shown some promising results in the repair of lung injuries.…”

Section: Therapeutic Applications Of Stem Cell Secretomementioning

confidence: 99%

Delivery of Stem Cell Secretome for Therapeutic Applications

Zhang

et al. 2022

ACS Appl. Bio Mater.

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Intensive studies on stem cell therapy reveal that benefits of stem cells attribute to the paracrine effects. Hence, direct delivery of stem cell secretome to the injured site shows the comparative therapeutic efficacy of living cells while avoiding the potential limitations. However, conventional systemic administration of stem cell secretome often leads to rapid clearance in vivo. Therefore, a variety of different biomaterials are developed for sustained and controllable delivery of stem cell secretome to improve therapeutic efficiency. In this review, we first introduce current approaches for the preparation and characterization of stem cell secretome as well as strategies to improve their therapeutic efficacy and production. The up-to-date delivery platforms are also summarized, including nanoparticles, injectable hydrogels, microneedles, and scaffold patches. Meanwhile, we discuss the underlying therapeutic mechanism of stem cell secretome for the treatment of various diseases. In the end, future opportunities and challenges are proposed.

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“…Polymeric nanoparticles are being used as potential candidates to carry anticancer agents to the specific site of tumors and facilitate targeted delivery to cancer cells. [209][210][211] The polymeric nanoparticles help in the controlled release of the drug in a time-dependent manner. 212 These nanoparticle surfaces can also be decorated with targeting ligands and labeled with imaging molecules for the specificity and effectiveness of cancer theranostics.…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%