Technetium-99<sup>m</sup>diethylenetriaminepentaacetic acid radioaerosol scintigraphy in organophosphate induced pulmonary toxicity: Experimental study

Yılmaz, Yücel; Kaya, Eser; Yürümez, Yusuf; Şahin, Önder; Baş, Orhan; Fidan, Hüseyin; Sezer, Murat

doi:10.1080/15563650701584111

Cited by 9 publications

(4 citation statements)

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“…We first reviewed the literature for validated scoring systems for OP poisoning. Pulmonary histopathology from animal studies showed that exposing lungs to OP insecticide (directly or indirectly) causes edema, hemorrhage, alveolar destruction and inflammation [ 21 , 22 , 24 – 26 ]. Two of the three scoring systems described in these studies used a 4-point semi-quantitative system [ 21 , 26 ] while other studies did not score the histological changes at all, choosing to take a qualitative, descriptive approach instead [ 24 , 25 ].…”

Section: Methodsmentioning

confidence: 99%

“…Two of the three scoring systems described in these studies used a 4-point semi-quantitative system [ 21 , 26 ] while other studies did not score the histological changes at all, choosing to take a qualitative, descriptive approach instead [ 24 , 25 ]. Only one of the three studies that used a pulmonary histopathology scoring system [ 21 , 22 , 26 ] reported the location and number of samples taken [ 21 ].…”

Section: Methodsmentioning

confidence: 99%

“…Yavuz et al used a detailed pulmonary histopathology scoring system [22] to study the effects of orogastric OP administration in rabbits. It evaluated eight histopathological features, each feature being awarded a score from 0 to 5.…”

Section: Rationale For Development Of Histopathology Scoring Systemmentioning

confidence: 99%

“…We searched for a validated pulmonary histopathological scoring system for OP poisoning in the pig but found only unvalidated systems developed for small animals such as rats and rabbits [ 21 , 22 ]. Although pulmonary histopathology scoring systems exist for gastric aspiration injury, none have been used to assess changes after aspiration of OP compounds and gastric juices.…”

Section: Introductionmentioning

confidence: 99%

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Development of a histopathology scoring system for the pulmonary complications of organophosphorus insecticide poisoning in a pig model

et al. 2020

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Organophosphorus (OP) insecticide self-poisoning causes over 100,000 global deaths annually. Around a third of patients are intubated and up to half of these can die. Post-mortem analysis of OP poisoned patients' lungs reveals consolidation, edema and hemorrhage, suggesting that direct or indirect lung damage may contribute to mortality. The lung injury caused by these formulated agricultural preparations is poorly characterised in humans, and a valid histopathology scoring system is needed in a relevant animal model to further investigate the disease and potential treatments. We conducted two pilot studies in anesthetized minipigs, which are commonly used for toxicological studies. In the first, pigs were given 2.5 mL/kg of either OP (n = 4) or saline (n = 2) by gavage and compared with positive controls (iv oleic acid n = 2). The second study simulated ingestion followed by gastric content aspiration: mixtures of OP (n = 3) or saline (n = 2) (0.63-0.71mL/kg) were placed in the stomach, and then small volumes of the gastric content were placed in the lung. At post-mortem examination, lungs were removed and inflation-fixed with 10% neutral buffered formalin. Samples (n = 62) were taken from cranial and caudal regions of both lungs. Two experienced lung histopathologists separately scored these samples using 8 proposed features of damage and their scores related (Kendall rank order). Two elements had small and inconsistent scores. When these were removed, the correlation increased from 0.74 to 0.78. Eight months later, a subset of samples (n = 35) was re-scored using the modified system by one of the previous histopathologists, with a correlation of 0.88. We have developed a reproducible pulmonary histopathology scoring system for OP poisoning in pigs which will assist future toxicological research and improve understanding and treatment of human OP poisoning.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Rationale For Development Of Histopathology Scoring Systemmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development of a histopathology scoring system for the pulmonary complications of organophosphorus insecticide poisoning in a pig model

et al. 2020

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Xuebijing injection induces anti-inflammatory-like effects and downregulates the expression of TLR4 and NF-κB in lung injury caused by dichlorvos poisoning

Wang

Liu

et al. 2018

Biomedicine & Pharmacotherapy

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Protective effect of catechin and quercetin on chlorpyrifos-induced lung toxicity in male rats

Uzun

Demir

Kalender

et al. 2010

Food and Chemical Toxicology

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Technetium-99^mdiethylenetriaminepentaacetic acid radioaerosol scintigraphy in organophosphate induced pulmonary toxicity: Experimental study

Abstract: This study showed that OP toxicity caused a decrease in the alveolar clearance. Tc-99m DTPA radioaerosol inhalation lung scintigraphy was found to be a sensitive determination of acute lung damage in OP poisoning.

Cited by 9 publications

References 28 publications

Development of a histopathology scoring system for the pulmonary complications of organophosphorus insecticide poisoning in a pig model

Development of a histopathology scoring system for the pulmonary complications of organophosphorus insecticide poisoning in a pig model

Xuebijing injection induces anti-inflammatory-like effects and downregulates the expression of TLR4 and NF-κB in lung injury caused by dichlorvos poisoning

Protective effect of catechin and quercetin on chlorpyrifos-induced lung toxicity in male rats

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Technetium-99mdiethylenetriaminepentaacetic acid radioaerosol scintigraphy in organophosphate induced pulmonary toxicity: Experimental study

Abstract: This study showed that OP toxicity caused a decrease in the alveolar clearance. Tc-99m DTPA radioaerosol inhalation lung scintigraphy was found to be a sensitive determination of acute lung damage in OP poisoning.

Cited by 9 publications

References 28 publications

Development of a histopathology scoring system for the pulmonary complications of organophosphorus insecticide poisoning in a pig model

Development of a histopathology scoring system for the pulmonary complications of organophosphorus insecticide poisoning in a pig model

Xuebijing injection induces anti-inflammatory-like effects and downregulates the expression of TLR4 and NF-κB in lung injury caused by dichlorvos poisoning

Protective effect of catechin and quercetin on chlorpyrifos-induced lung toxicity in male rats

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Technetium-99^mdiethylenetriaminepentaacetic acid radioaerosol scintigraphy in organophosphate induced pulmonary toxicity: Experimental study