Xuebijing injection induces anti-inflammatory-like effects and downregulates the expression of TLR4 and NF-κB in lung injury caused by dichlorvos poisoning

He, Fei; Wang, Jun; Liu, Yao; Wang, Xiaojing; Cai, Nan; Wu, Chao; Gao, Qiang

doi:10.1016/j.biopha.2018.07.111

Cited by 27 publications

(15 citation statements)

References 25 publications

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“…In addition, a meta-analysis revealed that the combined treatment of XBJI and western medicine showed better efficiency than western medicine treatment alone with significantly decreasing 28-day mortality and shorting ICU stay time [ 433 ]. Pharmacological research revealed that XBJI could prevent CLP-, dichlorvos-, paraquat- or I/R-induced ALI through decreasing inflammatory responses and oxidative stress; during the process, p38 MAPK and TLR4-mediated NF-κB signaling pathways were involved [ [434] , [435] , [436] , [437] ].…”

Section: Potential Clinical Use Of Natural Compounds For Alimentioning

confidence: 99%

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

Zhou

et al. 2021

Pharmacological Research

216

121

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Section: Potential Clinical Use Of Natural Compounds For Alimentioning

confidence: 99%

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

Zhou

et al. 2021

Pharmacological Research

216

121

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“…XBJ can not only anti-inflammatory but also direct action on SARS-CoV-2 in treating COVID-19. In terms of anti-inflammatory, XBJ injection reduces inflammatory reaction by down-regulating the expression of TLR4 and NF-κB, preventing lung injury caused by DDVP poisoning (He et al, 2018). XBJ improves survival in septic shock, and its mechanism is also related to inhibition of the immune response by preventing cytokine storm attack and regulating the balance of Tregs/Th17 cells (Chen et al, 2018).…”

Section: Xue Bi Jing Injectionmentioning

confidence: 99%

Potential Therapeutic Effect of Traditional Chinese Medicine on Coronavirus Disease 2019: A Review

et al. 2020

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The Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 has been rapidly spreading globally and has caused worldwide social and economic disruption. Currently, no specific antiviral drugs or clinically effective vaccines are available to prevent and treat COVID-19. Traditional Chinese medicine (TCM) can facilitate syndrome differentiation and treatment according to the clinical manifestations of patients and has demonstrated effectiveness in epidemic prevention and control. In China, TCM intervention has helped to control the epidemic; however, TCM has not been fully recognized worldwide. In this review, we summarize the epidemiology and etiological characteristics of severe acute respiratory syndrome coronavirus 2 and the prevention and treatment measures of COVID-19. Additionally, we describe the application of TCM in the treatment of COVID-19 and the identification of small molecules of TCM that demonstrate anti-coronavirus activity. We also analyze the current problems associated with the recognition of TCM. We hope that, through the contribution of TCM, combined with modern technological research and the support of our international counterparts, COVID-19 can be effectively controlled and treated.

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“…At the molecular level, XBJ regulates multiple signaling pathways to combat organ injuries. It down-regulated TLR4 signaling and stimulated the expression of Toll-interacting protein to improve organ functions (Liu et al, 2014b;Liu et al, 2014c;He et al, 2018). XBJ reduced ROS production in rats to attenuate pulmonary injury (Chen et al, 2017).…”

Section: Xbj and Organ Failurementioning

confidence: 99%

Xuebijing Injection Maintains GRP78 Expression to Prevent Candida albicans–Induced Epithelial Death in the Kidney

Shang

Ren

et al. 2020

Front. Pharmacol.

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Sepsis and septic shock threaten the survival of millions of patients in the intensive care unit. Secondary fungal infections significantly increased the risk of mortality in sepsis patients. Chinese medicine Xuebijing injection (XBJ) has been routinely used as an add-on treatment to sepsis and septic shock in China. Our network pharmacology analysis predicted that XBJ also influences fungal infection, consisting with results of pioneer clinical studies. We conducted in vivo and in vitro experiments to verify this prediction. To our surprise, XBJ rescued mice from lethal Candida sepsis in a disseminated Candida albicans infection model and abolished the colonization of C. albicans in kidneys. Although XBJ did not inhibit the growth and the virulence of C. albicans in vitro, it enhanced the viability of 293T cells upon C. albicans insults. Further RNA-seq analysis revealed that XBJ activated the endoplasmic reticulum (ER) stress pathway upon C. albicans infection. Western blot confirmed that XBJ maintained the expression of GRP78 in the presence of C. albicans. Interestingly, key active ingredients in XBJ (C0127) mirrored the effects of XBJ. C0127 not only rescued mice from lethal Candida sepsis and prevented the colonization of C. albicans in kidneys, but also sustained the survival of kidney epithelial cells partially by maintaining the expression of GRP78. These results suggested that XBJ may prevent fungal infection in sepsis patients. Pre-activation of ER stress pathway is a novel strategy to control C. albicans infection. Network pharmacology may accelerate drug development in the field of infectious diseases.

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Xuebijing injection induces anti-inflammatory-like effects and downregulates the expression of TLR4 and NF-κB in lung injury caused by dichlorvos poisoning

Cited by 27 publications

References 25 publications

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

Potential Therapeutic Effect of Traditional Chinese Medicine on Coronavirus Disease 2019: A Review

Xuebijing Injection Maintains GRP78 Expression to Prevent Candida albicans–Induced Epithelial Death in the Kidney

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