Protective effect of catechin and quercetin on chlorpyrifos-induced lung toxicity in male rats

Uzun, Fatma; Demir, Filiz; Kalender, Suna; Baş, Hatice; Kalender, Yusuf

doi:10.1016/j.fct.2010.03.051

Cited by 78 publications

(45 citation statements)

References 52 publications

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“…That decrease was statistically significant and slightly more intensive in females than in males. In similar research on male rats, Uzun et al (2010) observed increase in SOD and CAT activity and decrease in GPx in lungs after administration of chlorpyrifos during 28 days. Goel et al (2005) after exposure of rats to chlorpyrifos during 8 weeks at the dose of 13.5 mg/kg bw (1/10 LD 50 ) noted increase in SOD and GSH-Px and decrease in CAT activity in liver.…”

Section: Group Of Animalsmentioning

confidence: 76%

“…More and more information concerning co-action of phosphoroorganic insecticides and medicines with different compounds on oxidative processes has been published recently (Anderson and Zhu 2004, Sivapiriya et al 2006, Uzun et al 2010). Most of investigations however, concerns protective action of vitamins and minerals during exposure to phosphoroorganic insecticides.…”

Section: Group Of Animalsmentioning

confidence: 99%

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Activity of superoxide dysmutase, catalase and glutathione peroxidase in rats exposed to chlorpyrifos and erofloxacin

Barski¹,

Spodniewska²,

Zasadowski³

2011

Polish Journal of Veterinary Sciences

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The aim of the study was to investigate the influence of administration of chlorpyrifos and/or enrofloxacin on the activity of chosen antioxidative enzymes i.e.: superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) in erythrocytes of rats. Chlorpyrifos was administered by stomach tube during 28 days at a dose of 3 mg/kg bw (0.02 LD 50 ), and enrofloxacin was administered by stomach tube at a dose of 5 mg/kg bw during 3 subsequent days. It was stated that administration of enrofloxacin at applied dose did not cause any major changes in the activity of investigated antioxidative enzymes. The four-week exposure of rats to chlorpyrifos caused noticeable decrease in SOD and CAT activity in erythrocytes of rats at the beginning of the experiment (up to 24 th hour) in comparison with the control group. The activity of GPx during all periods of the experiment was increased. In the group of animals in which both chlorpyrifos and enrofloxacin were applied, the profile of changes in activity of examined enzymes was similar to that one, which was observed after administration of chlorpyrifos exclusively, what may indicate lack of co-action between compounds used in the experiment.

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Section: Group Of Animalsmentioning

confidence: 76%

Section: Group Of Animalsmentioning

confidence: 99%

Activity of superoxide dysmutase, catalase and glutathione peroxidase in rats exposed to chlorpyrifos and erofloxacin

Barski¹,

Spodniewska²,

Zasadowski³

2011

Polish Journal of Veterinary Sciences

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“…Que is one of the most common flavonoids in the diet, distributed in many vegetables, fruits and other foods [28]. Que is an effective antioxidant which can directly remove oxide free radicals, inhibit lipid peroxidation and change in vivo and in vitro antioxidant defense pathways [12].…”

Section: Discussionmentioning

confidence: 99%

Protection of Quercetin against Triptolide-induced apoptosis by suppressing oxidative stress in rat Leydig cells

Zhao

et al. 2015

Chemico-Biological Interactions

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“…(Eraslan et al 2009;Uzun et al 2010). It is reported that carbosulfan enhance the production of ROS, and it alters the enzyme activities associated with antioxidant defence mechanisms in the spleen of male Wistar rats (ElBini Dhouib et al 2014).…”

Section: Carbosulfan-induced Oxidative Damage Following Subchronic Exmentioning

confidence: 99%

Carbosulfan-induced oxidative damage following subchronic exposure and the protective effects of N-acetylcysteine in rats

Dhouib¹,

Annabi²,

Jrad³

et al. 2015

gpb

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Abstract. Carbosulfan (CB)-induced oxidative stress leads to the inevitable accumulation of free radicals and eventual alteration of antioxidant enzymes in various biological systems. The present study is designed to investigate the preventive effect of N-acetylcysteine (NAC) on carbosulfaninduced hepatic and renal dysfunction in rats. Rats exposed to CB and NAC were examined for toxicity by assessing various biochemical alteration and stress markers including in liver and kidney. Significant increases of blood alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma glutamyltransferase (GGT), creatinine and urea were detected in CB-treated rats. In addition, the levels of antioxidative enzymes such as catalase (CAT), superoxide dismutase (SOD) and reduced glutathione (GSH) also were assessed. According to the results, rats exposed to carbosulfan showed a significant increase in the accumulation of stress markers and an alteration in the antioxidative enzymes activity, when compared to their respective controls. Interestingly, administration of NAC to CB-treated rats attenuates the toxicity of this compound, objectified by biochemical and oxidative improvement of liver and kidney. Thus, the present study reports for the first time that NAC could be a promising therapeutic agent against CB-induced oxidative stress.

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Protective effect of catechin and quercetin on chlorpyrifos-induced lung toxicity in male rats

Cited by 78 publications

References 52 publications

Activity of superoxide dysmutase, catalase and glutathione peroxidase in rats exposed to chlorpyrifos and erofloxacin

Activity of superoxide dysmutase, catalase and glutathione peroxidase in rats exposed to chlorpyrifos and erofloxacin

Protection of Quercetin against Triptolide-induced apoptosis by suppressing oxidative stress in rat Leydig cells

Carbosulfan-induced oxidative damage following subchronic exposure and the protective effects of N-acetylcysteine in rats

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