Protection of Quercetin against Triptolide-induced apoptosis by suppressing oxidative stress in rat Leydig cells

Glycyrrhetinic Acid Accelerates the Clearance of Triptolide through P‐gp In Vitro

“…Studies reported that Farnesoid X receptor (FXR) and Nrf2 pathway played a significant role in protecting against TP‐induced toxicity (Jin et al, ; Li et al, ; Li et al, ). Some compounds including quercetin, isoliquiritigenin and GA were discovered to provide protection against TP‐induced toxicity through its antioxidant properties (Hu et al, ; Cao et al, ).…”

Chokeberries (Aronia melanocarpa) and Their Products as a Possible Means for the Prevention and Treatment of Noncommunicable Diseases and Unfavorable Health Effects Due to Exposure to Xenobiotics

“…The authors reported that anthocyanins present in chokeberry extract protected from oxidative stress in the erythrocytes of rabbits caused by cyclophosphamide (an anticancer alkylating drug) and protected healthy cells from a decrease in the activities of antioxidative enzymes during chemotherapy. The number of reports on the beneficial impact of products of A. melanocarpa berries and particular polyphenolic compounds present in them under exposure to various substances has been increasing from year to year (Braun and others ; Kujawska and others ; Prabu and others ; Szaefer and others ; Balansky and others ; Krishnakumar and others ; Brzóska and others , ,b, ; Roszczenko and others ; Wang and others ; Dietrich‐Muszalska and others ; Khandelwal and Abraham ; Koriem and Soliman ; Navaneethan and Rasool ; Papież and Krzyściak ; Podder and others ; Qader and others ; Hao and others ; Hu and others ).…”

“…Moreover, A. melanocarpa extract has been reported to protect from the harmfulness of tobacco smoke (Balansky and others ). Apart from that, a protective effect of some polyphenolic compounds present in chokeberries, such as chlorogenic acid, quercetin, kaempferol, caffeic acid, p‐coumaric acid, cyanidin, and pelargonidin, has been revealed regarding the chosen effects of toxic action of Cd (Morales and others ; Vicente‐Sánchez and others ; Renugadevi and Prabu ; Prabu and others ; Krishnakumar and others ; Wang and others ; Navaneethan and Rasool ; Hao and others ), Pb (Liu and others ), ethanol (Molina and others ; Liu and others ), paraquat (Tsuchiya and others ; Park and others ; Podder and others ), sulfur mustard (Kumar and others ; Gautam and others ), methamphetamine (Koriem and Soliman ), diepoxybutane (Khandelwal and Abraham ), urethane (Khandelwal and Abraham ), tobacco smoke (Braun and others ), and some medicines (Kuhlmann and others ; Papież and Krzyściak ; Qader and others ; Hu and others ). These findings provide confirmation of the effectiveness of aronia berry products as well as help to explain, at least partially, the possible mechanisms of the positive impact of A. melanocarpa products regarding the toxicity of xenobiotics.…”

“…Research performed in laboratory animals and with in vitro models indicates that extracts and juice from A. melanocarpa berries may protect from toxic effects connected with pro‐oxidative and pro‐inflammatory properties of some drugs, including amiodarone (an antiarrhythmic causing pneumotoxicity; Valcheva‐Kuzmanova and others ), indomethacin (a nonsteroidal anti‐inflammatory drug; Valcheva‐Kuzmanova and others ), cisplatin (a cytotoxic chemotherapy drug; Valcheva‐Kuzmanova and others ), cyclophosphamide (an anticancer alkylating drug; Niedworok and others ), and ziprasidone (an antipsychotic drug used in patients suffering from schizophrenia; Dietrich‐Muszalska and others ). Moreover, quercetin (commercially available pure compound) has been reported to prevent some side effects of paracetamol (an over‐the‐counter analgesic and antipyretic drug; El‐Shafey and others ), isoniazid (an antibiotic used as a 1st‐line agent in the prevention and treatment of tuberculosis; Qader and others ), rifampicin (an antibiotic used in the treatment of tuberculosis, influenza, and meningococcal disease; Qader and others ), etoposide (a 1st‐line anticancer drug used in the treatment of tumors, lymphomas, and leukemias; Papież and Krzyściak ), triptolide (a diterpene triepoxide with anti‐inflammatory, anticancerogenic, immunomodulatory, and proapoptotic activities obtained from the medicinal plant Triterygium wilfordii ; Hu and others ), and cisplatin (Kuhlmann and others ).…”

Tricholoma matsutake Aqueous Extract Induces Hepatocellular Carcinoma Cell Apoptosis via Caspase-Dependent Mitochondrial Pathway

“…On the other hand, hyperlevel of oxidative stress leads to the modification of amino acid residues thereby causing DNA mutations and cell apoptosis [15]. The overgeneration of reactive oxygen species (ROS) causes intracellular oxidative stress and further aggravates mitochondrial depolarization [16]. …”