Tear osteopontin level and its relationship with local Th1/Th2/Th17/Treg cytokines in children with allergic conjunctivitis

Yan, A.; Luo, Guoping; Zhou, Zhixiang; Hang, W.; Qin, Dajun

doi:10.1016/j.aller.2017.05.005

Cited by 11 publications

(9 citation statements)

References 25 publications

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“…OPN is a multifunctional extracellular matrix protein produced by a variety of cells and tissues. It is a major amplifier of the Th1-immune response and has been recognized as a proinflammatory cytokine associated with local inflammation 47. Therefore, increased level of BM OPN could promote the Th1 response, which might be a possible explanation for BM Th1 upregulation in ITP.…”

Section: Discussionmentioning

confidence: 99%

Disrupted balance of CD4⁺ T-cell subsets in bone marrow of patients with primary immune thrombocytopenia

Wang¹,

Li²,

Yu³

et al. 2019

Int. J. Biol. Sci.

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Disequilibrium of CD4 + T-cell subpopulations in peripheral blood (PB) of patients with primary immune thrombocytopenia (ITP) has been well established, whereas the profile of CD4 + T-cell subpopulations in bone marrow (BM) remains elusive. In the present study, the frequencies of T helper 22 (Th22), Th17, Th1, Th2, follicular T helper (Tfh) cells and regulatory T cells (Tregs) as well as their effector cytokines in BM and PB from active ITP patients and healthy controls (HCs) were determined. Results showed that the frequencies of Th22, Th17, Th1, and Tfh cells were significantly higher, but Treg number was remarkably lower in BM from ITP patients than from HCs. In the ITP group, it was notable that the numbers of BM Th22, Th17, Th1, Th2, and Tfh cells were significantly elevated compared with the matched PB counterparts, while Treg number in BM was considerably reduced compared with that in PB. In consistence with the BM Th subset pattern, plasma levels of interleukin (IL)-22, IL-17A, and interferon (INF)-γ in BM from ITP patients were significantly increased compared with that from HCs. Therefore, the balance of CD4 + T-cell subsets was disrupted in both BM and PB of ITP patients, suggesting that this might play important roles in the pathophysiological process of ITP.

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Section: Discussionmentioning

confidence: 99%

Disrupted balance of CD4⁺ T-cell subsets in bone marrow of patients with primary immune thrombocytopenia

Wang¹,

Li²,

Yu³

et al. 2019

Int. J. Biol. Sci.

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“…In allergic rhinitis, upregulated SPP1 expression induced by leptin facilitates Th2 inflammation, and this process is mediated by α 4 integrin and PI3K/Akt pathway [24]. Tear OPN expression in patients with perennial allergic conjunctivitis (AC) is higher than that in patients with seasonal AC due to the pollen season and in healthy controls; therefore, tear OPN expression possibly functions in local Th2/17 cytokine production and positively correlates with disease severity [25]. However, the roles of TNC and SPP1 in acne have not been reported until now.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Potential Genes and Pathways Involved in the Pathogenesis of Acne by Bioinformatics

Chen

Zheng

Liang

2019

BioMed Research International

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Acne is the eighth most frequent disease worldwide. Inflammatory response runs through all stages of acne. It is complicated and is involved in innate and adaptive immunity. This study aimed to explore the candidate genes and their relative signaling pathways in inflammatory acne using data mining analysis. Microarray data GSE6475 and GSE53795, including 18 acne lesion tissues and 18 matched normal skin tissues, were obtained. Differentially expressed genes (DEGs) were filtered and subjected to functional and pathway enrichment analyses. Protein–protein interaction (PPI) network and module analyses were also performed based on the DEGs. In this work, 154 common DEGs, including 145 upregulated and 9 downregulated, were obtained from two microarray profiles. Gene Ontology and pathway enrichment of DEGs were clustered using significant enrichment analysis. A PPI network containing 110 nodes/DEGs was constructed, and 31 hub genes were obtained. Four modules in the PPI network, which mainly participated in chemokine signaling pathway, cytokine–cytokine receptor interaction, and Fc gamma R-mediated phagocytosis, were extracted. In conclusion, aberrant DEGs and pathways involved in acne pathogenesis were identified using bioinformatic analysis. The DEGs included FPR2, ITGB2, CXCL8, C3AR1, CXCL1, FCER1G, LILRB2, PTPRC, SAA1, CCR2, ICAM1, and FPR1, and the pathways included chemokine signaling pathway, cytokine–cytokine receptor interaction, and Fc gamma R-mediated phagocytosis. This study could serve as a basis for further understanding the pathogenesis and potential therapeutic targets of inflammatory acne.

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“…Several studies have investigated the role of OPN in promoting chemotactic inflammatory cells such as eosinophils and mast cells [100,101]. e correlation between OPN and disease severity and high OPN expression during allergy season suggest that OPN can be used as a possible biomarker for the differential diagnosis of other diseases, monitoring disease activity or response to treatment [101]. [102,103].…”

Section: Opn Opn Expression Is Enhanced In 2 Diseasesmentioning

confidence: 99%

The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis

Meng

Shi

Zhang

et al. 2020

Journal of Ophthalmology

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Allergic conjunctivitis (AC) is a common allergic disease that is often associated with the onset of rhinitis or asthma. The incidence of AC has increased significantly in recent years possibly due to air pollution and climate warming. AC seriously affects patients’ quality of life and work efficiency. Th (T-helper) 2 immune responses and type I hypersensitivity reactions are generally considered the basis of occurrence of AC. It has been found that new subpopulations of T-helper cells, Th17 cells that produce interleukin-17 (IL-17), play an important role in the Th2-mediated pathogenesis of conjunctivitis. Studies have shown that Th17 cells are involved in a variety of immune inflammation, including psoriasis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, and asthma. However, the role of Th17 and IL-17 in AC is unclear. This paper will focus on how T-helper 17 cells and interleukin-17 are activated in the Th2 immune response of allergic conjunctivitis and how they promote the Th2 immune response of AC.

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Tear osteopontin level and its relationship with local Th1/Th2/Th17/Treg cytokines in children with allergic conjunctivitis

Abstract: Tear OPN reflects the local clinical status of ocular allergy and might play an important pathophysiological role in local Th2/17/Treg inflammation in children with AC.

Cited by 11 publications

References 25 publications

Disrupted balance of CD4⁺ T-cell subsets in bone marrow of patients with primary immune thrombocytopenia

Disrupted balance of CD4⁺ T-cell subsets in bone marrow of patients with primary immune thrombocytopenia

Analysis of Potential Genes and Pathways Involved in the Pathogenesis of Acne by Bioinformatics

The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis

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Tear osteopontin level and its relationship with local Th1/Th2/Th17/Treg cytokines in children with allergic conjunctivitis

Abstract: Tear OPN reflects the local clinical status of ocular allergy and might play an important pathophysiological role in local Th2/17/Treg inflammation in children with AC.

Cited by 11 publications

References 25 publications

Disrupted balance of CD4+ T-cell subsets in bone marrow of patients with primary immune thrombocytopenia

Disrupted balance of CD4+ T-cell subsets in bone marrow of patients with primary immune thrombocytopenia

Analysis of Potential Genes and Pathways Involved in the Pathogenesis of Acne by Bioinformatics

The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis

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Product

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Disrupted balance of CD4⁺ T-cell subsets in bone marrow of patients with primary immune thrombocytopenia

Disrupted balance of CD4⁺ T-cell subsets in bone marrow of patients with primary immune thrombocytopenia