The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis

Meng, Xiang-Tian; Shi, Yun-Yue; Zhang, Hong; Zhou, Hongyan

doi:10.1155/2020/6917185

Cited by 15 publications

(13 citation statements)

References 120 publications

(160 reference statements)

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“…6 The role of IL-17A in allergic and atopic diseases is unclear. The current findings shown in Table 1 are in accordance with those of a previous study, which showed that activation of Th17 cells promoted Th2 activity and was associated with symptoms of allergy, 20,21 such as allergic conjunctivitis and allergic rhinitis. This could be explained by the common pathophysiology of all atopic diseases such as asthma and allergic conjunctivitis.…”

Section: Discussionsupporting

confidence: 92%

The Diagnostic Utility of Interleukin-13 and Interleukin-17A using the ELISA Technique in Asthmatic Children

AL-Hasnawi¹,

Al-khayat²

2022

J. Pure Appl. Microbiol.

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The heterogeneous etiology of asthma makes its diagnosis complicated. Measurement of cytokine levels could be relevant in determining the asthma phenotype, predicting severity, and identifying the treatment type. Enzyme-linked immunosorbent assay (ELISA) is one of the most reliable methods, with high sensitivity and specificity. This study aimed to determine the accuracy and utility of interleukin (IL)-13 and IL-17 A in diagnosing children with asthma. A total of 74 asthmatic and 75 healthy children were enrolled in this case-control study between 10/2019 and 3/2021. Sera were collected and analyzed for IL-13 and IL-17A using ELISA. Diagnostic utility assessment was performed using receiver operating characteristic (ROC) analysis. The results showed that both cytokines had a significant capacity to differentiate patients with asthma from the control group. The sensitivity and specificity for IL-17A were 97.3% and 52.0%, respectively, whereas for IL-13 it was 81.1% and 52.0%, respectively. Positive predictive values (PPV) were 66.7% and 62.5% for IL-17A and IL-13, respectively. In conclusion, although both biomarkers had low specificity, IL-17A was more sensitive in differentiating children with asthma from those in the control group and had a higher sensitivity rate than IL-13.

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Section: Discussionsupporting

confidence: 92%

The Diagnostic Utility of Interleukin-13 and Interleukin-17A using the ELISA Technique in Asthmatic Children

AL-Hasnawi¹,

Al-khayat²

2022

J. Pure Appl. Microbiol.

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“…22 IL-6 is recognized as a marker of allergic asthma, 23 and is also the major regulator in the differentiation and function of Th17 cells, 24 which play an important role in the Th2-mediated allergic response through the production of IL-17. 25 The elevated levels of supernatant IL-33 and IL-6 from AR-NFs indicates an extensive immune-regulatory and also important proinflammatory roles of NFs in the development of AR. Inhibition the expression of these cytokines released from NFs is helpful to alleviate the progression of AR.…”

Section: Discussionmentioning

confidence: 99%

A comprehensive gene expression profile of allergic rhinitis-derived nasal fibroblasts and the potential mechanism for its phenotype

Zou

Sun

et al. 2022

Hum Exp Toxicol

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Background Allergic rhinitis (AR) is a common immunoglobulin E-mediated immune response involved various cell types, while the role of nasal fibroblasts (NFs) in the pathogenesis of AR is less understood. Purpose The study aimed to uncover the gene expression profile of AR-derived NFs and the potential mechanism for the changed phenotype of AR-NFs. Research Design The primary NFs were isolated from 3 AR patients (AR-NFs) and 3 controls (Ctrl-NFs), and the proliferation, migration and interleukins production abilities of NFs were detected respectively. RNA-sequence was used to identify differentially expressed genes (DEGs) in AR-NFs. Transcription factor (TF) regulatory network and bioinformatic analyses were both conducted to clarify the biological roles of DEGs including the TFs. The DEG with the highest validated |fold change (FC)| value, detected by qPCR, was selected for further confirmation. Results AR-NFs showed a higher proliferation and migration abilities as well as released higher levels of IL-33 and IL-6, compared to Ctrl-NFs. A total of 729 DEGs were screened out in AR-NFs. TF regulatory network indicated that BARX homeobox 1 (BARX1) and forkhead box L1 were the major node TFs. Bioinformatic analyses showed that a large number of DEGs including several target genes of BARX1 were both enriched cytokine-related GO terms, and immune- or inflammation-related pathways. BARX1 had the highest |FC| value, and silencing BARX1 in AR-NFs resulted in the significant downregulation of proliferation and migration abilities, and the production of interleukins. Conclusions Our study for the first time provided the gene expression profile of AR-derived NFs, and BARX1 could be developed as a potent target to alleviate the pathogenesis of AR.

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“…These allergies and B cells produce IgE, mast cell growth, and aggregation of eosinophil cells 16 . Eosinophil cells release histamine expression and induce conjunctival allergic reaction, such as hyperemia, microvascular permeability, cytokine secretion, etc 17 . It has been reported that PM 2.5 triggers AC by inducing serum IgE.…”

Section: Discussionmentioning

confidence: 99%

Air pollution and meteorological conditions significantly contribute to the worsening of allergic conjunctivitis: a regional 20-city, 5-year study in Northeast China

Liu

et al. 2021

Light Sci Appl

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This study is the first to explore the potential associations among allergic conjunctivitis (AC), air pollution, and meteorological conditions in Northeast China. Data of meteorology, ambient atmospheric pollutants, and the incidence of allergic conjunctivitis (IAC) in prefecture-level cities between the years 2014 and 2018 are analyzed. The results show an increasing trend in the AC of average growth rate per annum 7.6%, with the highest incidence in the provincial capitals. The IAC is positively correlated with atmospheric pollutants (i.e., PM2.5, PM10, CO, SO2, NO2, and O3) and meteorological factors (i.e., air temperature and wind speed), but negatively correlated with relative humidity. These results suggest that the IAC is directly proportional to pollution level and climatic conditions, and also the precedence of air pollution. We have further obtained the threshold values of atmospheric pollutants concentration and meteorological factors, a turning point above which more AC may be induced. Compared with the air quality standard advised by China and the World Health Organization (WHO), both thresholds of PM10 (70 μg m−3) and PM2.5 (45 μg m−3) are higher than current standards and pose a less environmental risk for the IAC. SO2 threshold (23 μg m−3) is comparable to the WHO standard and significantly lower than that of China’s, indicating greater environmental risks in China. Both thresholds of NO2 (27 μg m−3) and O3 (88 μg m−3) are below current standards, indicating that they are major environmental risk factors for the IAC. Our findings highlight the importance of atmospheric environmental protection and reference for health-based amendment.

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The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis

Cited by 15 publications

References 120 publications

The Diagnostic Utility of Interleukin-13 and Interleukin-17A using the ELISA Technique in Asthmatic Children

The Diagnostic Utility of Interleukin-13 and Interleukin-17A using the ELISA Technique in Asthmatic Children

A comprehensive gene expression profile of allergic rhinitis-derived nasal fibroblasts and the potential mechanism for its phenotype

Air pollution and meteorological conditions significantly contribute to the worsening of allergic conjunctivitis: a regional 20-city, 5-year study in Northeast China

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