Taurine provides antioxidant defense against NaF-induced cytotoxicity in murine hepatocytes

Das, Joydeep; Ghosh, Jyotirmoy; Manna, Prasenjit; Sil, Parames C.

doi:10.1016/j.pathophys.2008.06.002

Cited by 66 publications

(36 citation statements)

References 31 publications

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“…This has been supported by other studies that associate its protective antioxidant properties with direct scavenging of free radicals and indirect preserving of membrane permeability (22,23). TA has therefore become a promising option to treat chemically induced illnesses (14,(24)(25)(26)(27). Recent investigations have shown that TA protects cells from the toxic effects of cadmium (Cd), paracetamol, and arsenic (As) that are mediated by free-radical attack (28)(29)(30)(31).…”

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confidence: 75%

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The Effects of Taurine on Permethrininduced Cytogenetic and Oxidative Damage in Cultured Human Lymphocytes

Türkez

Aydın

2012

Archives of Industrial Hygiene and Toxicology

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The Effects of Taurine on Permethrininduced Cytogenetic and Oxidative Damage in Cultured Human LymphocytesPermethrin (PM) is a common pyrethroid pesticide used to control pests in agriculture, forestry, horticulture, health care, homes, and textile industry. It is confirmed as a strong mutagen in animals and humans. Taurine (TA) is an amino acid found in mammalian tissues that protects the cell against DNA damage. In this study, we investigated whether supplementation of human lymphocyte cultures with TA (in the concentrations of 25 μg mL-1, 50 μg mL-1and 100 μg mL-1) provided any protection against PM toxicity applied in the concentration of 200 μg mL-1. Genotoxicity was assessed using the micronucleus (MN) and sister chromatid exchanges (SCE) tests. In addition, we measured the total antioxidant capacity (TAC) and total oxidative stress (TOS) levels in the plasma to determine oxidative effects. PM increased SCE and MN levels and altered TAC and TOS levels. TA alone did not affect SCE and MN levels compared to controls, regardless of the concentration applied. In addition, it increased TAC levels without changing TOS levels. Moreover, it significantly buffered the negative cytogenetic and oxidative effects induced by PM in a clear dose-dependent manner. In conclusion, this study is the first to evidence the beneficial effects of TA against PM-induced DNA and oxidative damagesin vitro.

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confidence: 75%

“…Two hypotheses could explain the modulating effect of TA against PMinduced genotoxicity. The fi rst is that TA acts as an antioxidant in a dose-dependent manner (24). Through antioxidative pathways it seems to modify both target and receptor cell homeostasis (64)(65)(66).…”

Section: Discussionmentioning

confidence: 99%

The Effects of Taurine on Permethrininduced Cytogenetic and Oxidative Damage in Cultured Human Lymphocytes

Türkez

Aydın

2012

Archives of Industrial Hygiene and Toxicology

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“…It has been shown that taurine improves endothelial function and inhibits apoptosis of endothelial cell as well as decreases plasma level of LDL, which prevents initiation and progression of atherosclerosis (Fennessy et al, 2003;Murakami et al, 2002). Taurine exhibits antioxidative properties, membrane stabilizing effect, regulates intracellular Ca2+ concentration, inhibits apoptosis, reduces the levels of pro-inflammatory cytokines in various organs and controls blood pressure (Das et al, 2008;Manna et al, 2008;2009). Additionally, the protective effects of taurine against cyclosporine-A-induced oxidative stress and hepatotoxicity have been documented previously (Hagar et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Taurine Attenuates Hepatic and Cardiac Damage and Apoptosis in Rabbits Fed a High-Fat Diet

Abdel-Rahman¹

2014

OnLine Journal of Biological Sciences

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A hypercholesterolemia diet has been associated with the hepatic and cardiac abnormalities and the pathological changes. The present work was designed to investigate the histological and immunohistochemical changes in the liver and heart of rabbits when fed high fat diet and the possible protective role of an antioxidant "taurine". Twenty-four male white New Zealand rabbits were divided into four groups, 6 rabbits each. Group 1, served as a control, rabbits fed with a normal diet. Group 2, (taurine group), rabbits were given orally taurine (10 mg Kg −1 b.w/day) for 8 weeks. Group 3 (hypercholesterolemic group), rabbits fed (2% cholesterol-enriched diet for 8 weeks. Group 4, rabbits fed 2% cholesterol-enriched diet plus taurine (10 mg Kg −1 b.w/day) orally for the same period. Histopathological examinations revealed that high cholesterol diet caused hepatic and myocardial tissue changes compared with rabbits fed with a normal diet. Including fatty degeneration, inflammations and necrosis of Hepatocytes and vacuolar degeneration, disorganization of myofibrils and necrosis of myocardial cells. Immunohistochemistry for caspase-3 for apoptosis were performed. Caspase-3 positive cells in the liver tissue and Caspase-3 positive area in myocardial tissue increased in high cholesterol diet group. Taurine markedly attenuate hypercholesterolemia-induced cardiac and hepatic histopathological changes in the cholesterol plus taurine group compared to the cholesterol group. Thus, the results suggest that taurine could play a beneficial role against hypercholesterolemiainduced complications in the liver and heart of the rabbits.

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“…Taurine has an antioxidant effect and plays protective role against various toxic substances (for example lead and cadmium) [38,39,40,41]. Additionally, supplementation with taurine has been shown to prevent oxidative stress induced by exercise [42].…”

Section: Taurinementioning

confidence: 99%

Pharmacological Value of Caffeine, Taurine and Arginine in Nutritional Supplements and their Relation to Well Known Socially Important Diseases

Yotova¹

2015

IJNFS

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Email address: M_jotova@mu-pleven Abstract: Caffeine, Taurine and Arginine are one of the most widely used supplements from people of all ages. There are lot of controversial information about their proper use and effects and side effects. Our goal is to determine the reasonable boundaries of using these supplements in healthy people and more important in people with socially important diseases like high blood pressure, diabetes and dementia.

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Taurine provides antioxidant defense against NaF-induced cytotoxicity in murine hepatocytes

Cited by 66 publications

References 31 publications

The Effects of Taurine on Permethrininduced Cytogenetic and Oxidative Damage in Cultured Human Lymphocytes

The Effects of Taurine on Permethrininduced Cytogenetic and Oxidative Damage in Cultured Human Lymphocytes

Taurine Attenuates Hepatic and Cardiac Damage and Apoptosis in Rabbits Fed a High-Fat Diet

Pharmacological Value of Caffeine, Taurine and Arginine in Nutritional Supplements and their Relation to Well Known Socially Important Diseases

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