Taurine Attenuates Hepatic and Cardiac Damage and Apoptosis in Rabbits Fed a High-Fat Diet

Abdel-Rahman, Gamal Hasan

doi:10.3844/ojbsci.2014.12.20

Cited by 5 publications

(2 citation statements)

References 48 publications

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“…A clear hepatocyte radically arranged as cords or sheaths around central veins inside the portal lobule sinusoids were very clear between the cords of hepatocytes composed of endothelial and kupffer cells (figure 2a and b) in the present histological analysis of hepatic tissue in the normal group fed with a normal diet. The histological light microscopic analysis in the atherogenic group (rats fed a high-fat diet for 28 days) which shows certain changes in the liver structure, including congestion of the blood vessels and deposition of fat in the connective tissue between the lobules (figure 3 a and b), This observation was consistent with many studies that indicated that atherogenic diet induced fatty liver and hepatotoxicity [35,36] that suggested that hepatic tissue modifications were induced by a high cholesterol diet. In addition, other studies [37] indicate that atherogenic diets in rats with obesity have developed fatty liver disease.…”

Section: Liversupporting

confidence: 87%

The Effect of Saliva Officinalis L (Sage Tea) on Biochemical and Pathological Changes Improvment in Adult Male Rats Induced by a High Fat Diet

Naji¹,

Jabber²,

Jasim³

2021

Indian Journal of Forensic Medicine & Toxicology

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In order to investigate the physiological-protective effect of sage tea (Salvia officinalis L.) through its role in lipid profile regulation in male laboratory rats, current research has been carried out. In this study, sixty albino male laboratory rats (100-160 g) and older rats (4-7 weeks) were used. Based on the experimental nature of the study, animals were randomly divided into three main groups (six rats per group), a control group was considered to be the first group to be fed on a standard diet, and a 28-day atherogenic diet group was considered to be the second group to be fed on a standard diet (A). And the other group (B) (including subgroups) were previously fed 28 days on an atherogenic diet; oral administration was conducted as follows: the third group (B) included subgroups (B1) and (B2) administered 14 and 28 days of sage tea (S. officinalis) (0.086 mg/kg body weight) respectively. The measurement of changes in body weight and liver function enzymes (ALT, AST and ALP) and liver organ histopathology trials was done.In the results of the study, a significant increase (p ≤ 0.05) in the body weight of rats fed a high-fat diet (HFD) (group A) was seen compared to the control group fed a standard diet. Although body weights in The other groups were reduced in the sage tea treated group ( group B), the findings of the test of liver function enzymes in animals fed on an atherogenic diet (group A) revealed a substantial increase (p ≤ 0.05) in the level of the ALT enzyme associated with the non-changeable rate of the enzymes (AST) and (ALP), although they revealed a mild elevation relative to the control group. a slight decrease in all serum liver enzyme levels without significant difference in all experimental treatments (groups B) for both periods of 14 and 28 days. In relation to group (A), the increase and stabilization of liver enzyme levels at normal levels relative to control group values was reported, especially in the long term (28 days). In addition, histopathological examinations in the present sample showed histological changes in the liver organ compared with the control group due to feeding on a high fat diet (group A). These changes include blood vessels congestion, fat accumulation of liver connective tissue. In animals treated with sage tea (group A), a microscopic analysis of the liver showed typical histological characteristics with less fat deposition and minimal changes in histo-structural characteristics relative to the atherogenic diet group of animals. This indicates that improvement has been associated with long-term therapy (28 days). In conclusion, in reducing the functional performance and normal histological characteristics of long-term treatment-related liver and kidney organs, sage tea administration has an important synergistic protective role (28 days).

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Section: Liversupporting

confidence: 87%

The Effect of Saliva Officinalis L (Sage Tea) on Biochemical and Pathological Changes Improvment in Adult Male Rats Induced by a High Fat Diet

Naji¹,

Jabber²,

Jasim³

2021

Indian Journal of Forensic Medicine & Toxicology

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“…If left untreated, this can lead to liver necrosis and cirrhosis. In this study, the liver was also analyzed since it is the first organ to metabolize ingested cholesterol and is therefore the main target of the lipoxidative damage caused by an imbalance between generated free radicals and an ineffective antioxidant defense mechanism 71 .…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular and lipid-lowering effects of a marine lipoprotein extract in a high-fat diet-induced obesity mouse model

Carrera¹,

Corzo²,

Naidoo³

et al. 2023

Int. J. Med. Sci.

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Obesity is a major health challenge worldwide, with implications for diabetes, hypertension and cardiovascular disease (CVD). Regular consumption of dark-meat fish is linked to a lower incidence of CVD and associated metabolic disorders due to the presence of long-chain omega-3 fatty acid ethyl esters in fish oils. The aim of the present study was to determine whether a marine compound like a sardine lipoprotein extract (RCI-1502), regulates fat accumulation in the heart of a high-fat diet-induced (HFD) mouse model of obesity. To investigate its effects in the heart and liver, we conducted a randomized, 12-week placebo-controlled study in which we analyzed the expression of vascular inflammation markers, obesity biochemical patterns and related CVD pathologies. Male HFD-fed mice treated with a RCI-1502-supplemented diet showed reduced body weight, abdominal fat tissue and pericardial fat pad mass density without systemic toxicity. RCI-1502 significantly reduced triacylglyceride, low-density lipoprotein and total-cholesterol concentrations in serum, but increased HDL-cholesterol levels. Our data show that RCI-1502 is beneficial for reducing obesity associated with a long-term HFD, possibly by exerting a protective effect on lipidic homeostasis, indicated also by histopathological analysis. These results collectively indicate that RCI-1502 acts as a cardiovascular therapeutic nutraceutical agent, which modulates fat-induced inflammation and improves metabolic health.

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A synergistic protective effect of selenium and taurine against experimentally induced myocardial infarction in rats

Dallak

2017

Archives of Physiology and Biochemistry

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This study investigated the protective effect of subacute pre-adminsitration of either selenium (Se), taurine (Tau), or both drugs in combination against experimentally induced myocardial infarction (MI) in rats and illustrates the possible mechanisms of action. While solely pre-administration of Se or Tau resulted in partial amelioration in all of the measured parameters in MI rats, concomitant administration of both drugs to MI rats significantly restored contractility function by increasing LVSP and decreasing LVEDP and significantly normalized serum levels of LDH, CK-MB and BNP and restored normal cardiac architecture. This concomitant treatment acted by increasing the activity of major antioxidant enzymes (SOD and GPx), decreasing the levels of inflammatory markers including TNF-α, IL-6 as well as levels of Bcl-2 and caspase-3 and downregulating mRNA levels of Bax and P53, markers of apoptosis. In conclusion, a combination of Se and Tau provides a new strategy to alleviate MI-induced cardiac dysfunction.

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Taurine Attenuates Hepatic and Cardiac Damage and Apoptosis in Rabbits Fed a High-Fat Diet

Cited by 5 publications

References 48 publications

The Effect of Saliva Officinalis L (Sage Tea) on Biochemical and Pathological Changes Improvment in Adult Male Rats Induced by a High Fat Diet

The Effect of Saliva Officinalis L (Sage Tea) on Biochemical and Pathological Changes Improvment in Adult Male Rats Induced by a High Fat Diet

Cardiovascular and lipid-lowering effects of a marine lipoprotein extract in a high-fat diet-induced obesity mouse model

A synergistic protective effect of selenium and taurine against experimentally induced myocardial infarction in rats

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