Taurine, a conditionally essential amino acid, ameliorates arsenic-induced cytotoxicity in murine hepatocytes

Sinha, Mahua; Manna, Prasenjit; Sil, Parames C.

doi:10.1016/j.tiv.2007.05.010

Cited by 73 publications

(34 citation statements)

References 60 publications

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“…4) were more efficiently modulated by pretreatment, while posttreatment had a slight but promising effect on the enzyme activities. These results are consistent with previous studies on the beneficial effect of taurine [24,36,37,61]. Waters et al [21] reported that taurine administration before, simultaneously with, or an hour after acetaminophen resulted in significant improvement in hepatic injury, and this correlated with attenuation of lipid peroxidation.…”

Section: Discussionsupporting

confidence: 91%

“…Numerous studies have reported beneficial effects of taurine against toxic effects in liver induced by several xenobiotics such as ethanol [20], carbon tetrachloride [34], acetaminophen [21], thioacetamide [35], arsenic [36], and mercury [37] as well as in experimental liver fibrosis [38] and liver injury in chronic hepatitis patients [22]. The present study was undertaken to assess the effects of taurine pretreatment and posttreatment on oxidative stress parameters and chromium levels altered by Cr(VI) exposure in liver tissue of Swiss Albino mice.…”

Section: Discussionmentioning

confidence: 99%

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The Protective and Antidotal Effects of Taurine on Hexavalent Chromium-Induced Oxidative Stress in Mice Liver Tissue

Boşgelmez

Söylemezoğlu

Güvendik

2008

Biol Trace Elem Res

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Acute exposure to hexavalent chromium [Cr(VI)] compounds can cause hepatotoxicity. Reactive intermediates and free radicals generated during reduction process may be responsible for Cr(VI) toxicity. In this study, the effects of pretreatment or posttreatment of taurine on Cr(VI)-induced oxidative stress and chromium accumulation in liver tissue of Swiss Albino mice were investigated. Single intraperitoneal (ip) potassium dichromate treatment (20 mgCr/kg), as Cr(VI) compound, significantly elevated the level of lipid peroxidation as compared with control group ( p<0.05). This was accompanied by significant decreases in nonprotein sulfhydryls (NPSHs) level, superoxide dismutase (SOD), and catalase (CAT) enzyme activities as well as a significant chromium accumulation in the tissue ( p<0.05). Taurine administration (1 g/kg, ip) before or after Cr(VI) exposure resulted in reduction of lipid peroxidation ( p<0.05) showed rebalancing effect on tissue NPSH levels either in pretreatment or in posttreatment ( p<0.05). Enzyme activities of SOD and CAT were restored by taurine pretreatment ( p<0.05), whereas posttreatment had less pronounced effects on these parameters. On the other hand, taurine treatment, before or after exposure, could exert only slight decreases in tissue Cr levels ( p>0.05). In view of the results, taurine seems to exert some beneficial effects against Cr(VI)-induced oxidative stress in liver tissue.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

The Protective and Antidotal Effects of Taurine on Hexavalent Chromium-Induced Oxidative Stress in Mice Liver Tissue

Boşgelmez

Söylemezoğlu

Güvendik

2008

Biol Trace Elem Res

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“…Taurine modulates a variety of cellular functions, including antioxidation, ion movement, osmoregulation, modulation of neurotransmitters, conjugation of bile acids and membrane stabilization, regulates intracellular Ca 2? concentration, inhibits apoptosis and reduces the levels of pro-inflammatory cytokines (Aerts and Van Assche 2002;Das et al 2008Das et al , 2010aDas et al , b, 2011aGhosh et al 2009;Kontny et al 2000;Manna et al 2008aManna et al , b, 2009bRacasan et al 2004;Roy et al 2009;Roy and Sil 2012;Sinha et al 2007Sinha et al , 2008aSinha et al , b, 2009. Taurine inhibits nephrotoxicity, renal cell death (both apoptosis and necrosis), oxidative stress via increasing the activities of antioxidant enzymes and intracellular GSH and nitrosative stress, normalizes the Na ?…”

Section: Introductionmentioning

confidence: 99%

Taurine ameliorates alloxan-induced diabetic renal injury, oxidative stress-related signaling pathways and apoptosis in rats

2012

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Hyperglycemia-induced oxidative stress plays a vital role in the progression of diabetic nephropathy. The renoprotective nature of taurine has also been reported earlier; but little is known about the mechanism of this beneficial action. The present study has, therefore, been carried out to explore in detail the mechanism of the renoprotective effect of taurine under diabetic conditions. Diabetes was induced in rats by alloxan (single i.p. dose of 120 mg/kg body weight) administration. Taurine was administered orally for 3 weeks (1% w/v in drinking water) either from the day on which alloxan was injected or after the onset of diabetes. Alloxan-induced diabetic rats showed a significant increase in plasma glucose, enhanced the levels of renal damage markers, plasma creatinine, urea nitrogen and urinary albumin. Diabetic renal injury was associated with increased kidney weight to body weight ratio and glomerular hypertrophy. Moreover, it increased the productions of reactive oxygen species, enhanced lipid peroxidation and protein carbonylation in association with decreased intracellular antioxidant defense in the kidney tissue. In addition, hyperglycemia enhanced the levels of proinflammatory cytokins (TNF-α, IL-6, IL-1β) and Na(+)--K(+)-ATPase activity with a concomitant reduction in NO content and eNOS expression in diabetic kidney. Investigation of the oxidative stress-responsive signaling cascades showed the upregulation of PKCα, PKCβ, PKCε and MAPkinases in the renal tissue of the diabetic animals. However, taurine administration decreased the elevated blood glucose and proinflammatory cytokine levels, reduced renal oxidative stress (via decrease in xanthine oxidase activity, AGEs formation and inhibition of p47phox/CYP2E1 pathways), improved renal function and protected renal tissue from alloxan-induced apoptosis via the regulation of Bcl-2 family and caspase-9/3 proteins. Taurine supplementation in regular diet could, therefore, be beneficial to regulate diabetes-associated renal complications.

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“…As a non-toxic endogenous antioxidant, taurine has become an attractive candidate for attenuating various toxin-and drug-induced pathophysiological conditions (Holloway et al 1999;Das et al 2008Das et al , 2009aDas et al , b, 2010aDas et al , b, c, 2011Ghosh et al 2009;Manna et al 2008aManna et al , b, 2009Roy et al 2009;Sinha et al 2007Sinha et al , 2008aSinha et al , b, 2009. Taurine (2-aminoethanesulfonic acid) is a free b-amino acid and is present in high concentrations in several cell types.…”

Section: Introductionmentioning

confidence: 99%

Taurine protects rat testes against doxorubicin-induced oxidative stress as well as p53, Fas and caspase 12-mediated apoptosis

et al. 2011

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The protective effect of taurine against doxorubicin-induced testicular oxidative stress and apoptosis was investigated in rats. Male rats 8 weeks of age were treated with doxorubicin alone (3 mg/kg, i.p. every other day for 3 doses), taurine alone (150 mg/kg, i.p. every other day for 3 doses) or taurine plus doxorubicin (each dose given 1 day post-taurine). After 28 days, rat testes were collected and analysed. Rats treated with doxorubicin alone displayed reduced body and testicular weights, decreased sperm counts, increased the extent of testicular toxicity (as evident from the decreased activity of testicular marker enzyme, SDH) and oxidative stress (reduced GSH, increased GSSG and MDA levels), decreased antioxidant (SOD, CAT, GST, GPx, GR) and membrane-bound (Na+-K+ and Ca2+ ATPases) enzyme activities as well as plasma testosterone. Reverse transcriptase-PCR analysis revealed that doxorubicin induced a marked decrease in the expression of key enzymes for testicular androgenesis (3β-HSD, 17β-HSD) and testicular steroidogenic acute regulatory (StAR) protein. Western blot analysis showed that doxorubicin administration markedly increased the levels of caspase-9, 3, -8, -12, Fas, Bid and disturbed the Bcl-2 family protein balance. These results suggest that doxorubicin can trigger intrinsic, extrinsic and endoplasmic reticulum-associated apoptotic pathways in testicular pathophysiology. Doxorubicin also triggered activation of JNK, p38MAP kinases and p53. However, taurine could effectively prevent nearly all of these doxorubicin-induced testicular abnormalities, thereby proving to be an effective cytoprotectant.

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Taurine, a conditionally essential amino acid, ameliorates arsenic-induced cytotoxicity in murine hepatocytes

Cited by 73 publications

References 60 publications

The Protective and Antidotal Effects of Taurine on Hexavalent Chromium-Induced Oxidative Stress in Mice Liver Tissue

The Protective and Antidotal Effects of Taurine on Hexavalent Chromium-Induced Oxidative Stress in Mice Liver Tissue

Taurine ameliorates alloxan-induced diabetic renal injury, oxidative stress-related signaling pathways and apoptosis in rats

Taurine protects rat testes against doxorubicin-induced oxidative stress as well as p53, Fas and caspase 12-mediated apoptosis

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