The Protective and Antidotal Effects of Taurine on Hexavalent Chromium-Induced Oxidative Stress in Mice Liver Tissue

Abstract

Acute exposure to hexavalent chromium [Cr(VI)] compounds can cause hepatotoxicity. Reactive intermediates and free radicals generated during reduction process may be responsible for Cr(VI) toxicity. In this study, the effects of pretreatment or posttreatment of taurine on Cr(VI)-induced oxidative stress and chromium accumulation in liver tissue of Swiss Albino mice were investigated. Single intraperitoneal (ip) potassium dichromate treatment (20 mgCr/kg), as Cr(VI) compound, significantly elevated the level of lipid peroxidation as compared with control group ( p<0.05). This was accompanied by significant decreases in nonprotein sulfhydryls (NPSHs) level, superoxide dismutase (SOD), and catalase (CAT) enzyme activities as well as a significant chromium accumulation in the tissue ( p<0.05). Taurine administration (1 g/kg, ip) before or after Cr(VI) exposure resulted in reduction of lipid peroxidation ( p<0.05) showed rebalancing effect on tissue NPSH levels either in pretreatment or in posttreatment ( p<0.05). Enzyme activities of SOD and CAT were restored by taurine pretreatment ( p<0.05), whereas posttreatment had less pronounced effects on these parameters. On the other hand, taurine treatment, before or after exposure, could exert only slight decreases in tissue Cr levels ( p>0.05). In view of the results, taurine seems to exert some beneficial effects against Cr(VI)-induced oxidative stress in liver tissue.

Oxidative Stress Markers and Histological Analysis in Diverse Organs from Rats Treated with a Hepatotoxic Dose of Cr(VI): Effect of Curcumin

“…K 2 Cr 2 O 7 i.p. administered leads to liver dysfunction [15,20] since the hepatic portal vein carries Cr(VI) to the liver making it susceptible to the first and persistent exposition [21]. Moreover, Bosgelmez et al [20] revealed that a single intraperitoneal Cr(VI) administration caused a significant chromium accumulation in liver tissue.…”

“…administered leads to liver dysfunction [15,20] since the hepatic portal vein carries Cr(VI) to the liver making it susceptible to the first and persistent exposition [21]. Moreover, Bosgelmez et al [20] revealed that a single intraperitoneal Cr(VI) administration caused a significant chromium accumulation in liver tissue. Once Cr(VI) enters the body, it can efficiently penetrate cellular membranes through channels for isoelectric and isostructural anions, such as SO 4 2− and HPO 4 2− [22].…”

Investigation of biomarkers of early taurine deficiency in Florida pompano Trachinotus carolinus

“…Previous observation in fish (Espe and Holen, 2013;Goto et al, 2001Goto et al, , 2003Takagi et al, 2005) and mammals (Bosgelmez et al, 2008;Nandhini et al, 2002;Pasantes-Morales et al, 1980;Sawosz et al, 2004) identified the liver as a primary importance for taurine metabolism. Although the absence of significant change in AST and ALT activities suggests an absence of liver damage by the end of the present experiment, this is likely due to the short duration of this experiment.…”

Taurine: a critical nutrient for future fish feeds

“…Taurine has been linked to a number of health benefits, including tissue repair (Gupta et al, 2006;Kingston et al, 2004;Motawi et al, 2007;Sahin et al, 2011;Seki et al, 2005;Shiny et al, 2005;Takatani et al, 2004;Tong et al, 2006;Zhang et al, 2008;Zhang et al, 2010), alleviation of metal toxicity (Aydogdu et al, 2007;Bosgelmez and Guvendik, 2004;Bosgelmez et al, 2008;Gulyasar et al, 2010;Gurer et al, 2001) and bacterial lipopolysaccharide hepatotoxicity (Kim and Kim, 2002). Many of these actions result from two, cascading mechanisms.…”