Taurine protects rat testes against doxorubicin-induced oxidative stress as well as p53, Fas and caspase 12-mediated apoptosis

Das, Joydeep; Ghosh, Jyotirmoy; Manna, Prasenjit; Sil, Parames C.

doi:10.1007/s00726-011-0904-4

Cited by 125 publications

(71 citation statements)

References 64 publications

(60 reference statements)

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“…The results showed that GPx was elevated and MDA was reduced when DXR was given in conjunction with taurine in comparison to administration of DXR only. The authors concluded that oxidative stress played a role in DXR-induced testicular toxicity and that taurine alleviated this toxicity [19]. When we compared the groups in our study with regard to MDA and GPx, we observed a similar relationship, in which the level of MDA was lower but that of GPx was higher in the DXR + RA group than the DXR group.…”

Section: Discussionsupporting

confidence: 68%

Protective Effects of Rosmarinic Acid on Doxorubicin-Induced Testicular Damage

Üyetürk

Üyetürk²,

Fırat³

et al. 2014

Chemotherapy

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Background: We investigated the protective effects of rosmarinic acid (RA) on testicular damage induced by doxorubicin (DXR) in rats. Methods: In total, 21 rats were divided into 3 groups: the control group that received no treatment, the DXR group that received intraperitoneal (i.p.) DXR on day 7 and the DXR + RA group that received intragastric RA for 10 days with i.p. DXR on day 7. The rats were sacrificed on day 11 for histological and biochemical analyses. To assess oxidative damage, glutathione peroxidase (GPx) and malondialdehyde (MDA) levels were measured. Results: The median modified Johnsen score of the DXR + RA group was higher than that of the DXR group (p = 0.002). The rats with the narrowest seminiferous tubules were in the DXR group (0.17 ± 0.03), and the difference between the DXR + RA and DXR groups was statistically significant (p = 0.002). The number of apoptotic cells in the DXR group was significantly higher than that in the control group, and there were significantly fewer apoptotic cells in the DXR + RA group than in the DXR group (p = 0.002). The MDA level was lowest in the control group and highest in the DXR group, and the level observed in the DXR + RA group significantly lower than that in the DXR group (p = 0.002). The GPx level was highest in the control group, with the level observed in the DXR + RA group significantly higher than that in the DXR group (p = 0.002). The testosterone level was lowest in the DXR group and highest in the control group, and that observed in the DXR + RA group was significantly higher than that in the DXR group (p = 0.018). Conclusions: RA can correct DXR-induced testicular damage through its antioxidant properties. However, the mechanism underlying the effects of RA requires further investigation, and long-term and comparative human studies are also needed.

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Section: Discussionsupporting

confidence: 68%

Protective Effects of Rosmarinic Acid on Doxorubicin-Induced Testicular Damage

Üyetürk

Üyetürk²,

Fırat³

et al. 2014

Chemotherapy

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“…Adding TA does not make it toxic in cells where it is already present in high concentration. Moreover, supplementation with TA (150 mg kg -1 or ~1.87 g L -1 ) in a recent study (20) prevented oxidative stress induced by doxorubicin. However, concentrations this high may lead to saturation.…”

Section: Discussionmentioning

confidence: 95%

“…These include various vitamins, propolis, sulphhydryl compounds, and plant products (15)(16)(17)(18)(19). Taurine (TA) (2-aminoethanesulfonic acid) is found in high concentrations in various mammalian tissues (20). Sung et al (21) reported that TA suppressed oxidant-induced tissue injuries by stabilising the biomembrane and by scavenging free radicals (21).…”

mentioning

confidence: 99%

The Effects of Taurine on Permethrininduced Cytogenetic and Oxidative Damage in Cultured Human Lymphocytes

Türkez

Aydın

2012

Archives of Industrial Hygiene and Toxicology

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The Effects of Taurine on Permethrininduced Cytogenetic and Oxidative Damage in Cultured Human LymphocytesPermethrin (PM) is a common pyrethroid pesticide used to control pests in agriculture, forestry, horticulture, health care, homes, and textile industry. It is confirmed as a strong mutagen in animals and humans. Taurine (TA) is an amino acid found in mammalian tissues that protects the cell against DNA damage. In this study, we investigated whether supplementation of human lymphocyte cultures with TA (in the concentrations of 25 μg mL-1, 50 μg mL-1and 100 μg mL-1) provided any protection against PM toxicity applied in the concentration of 200 μg mL-1. Genotoxicity was assessed using the micronucleus (MN) and sister chromatid exchanges (SCE) tests. In addition, we measured the total antioxidant capacity (TAC) and total oxidative stress (TOS) levels in the plasma to determine oxidative effects. PM increased SCE and MN levels and altered TAC and TOS levels. TA alone did not affect SCE and MN levels compared to controls, regardless of the concentration applied. In addition, it increased TAC levels without changing TOS levels. Moreover, it significantly buffered the negative cytogenetic and oxidative effects induced by PM in a clear dose-dependent manner. In conclusion, this study is the first to evidence the beneficial effects of TA against PM-induced DNA and oxidative damagesin vitro.

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“…Group II rats were exposed to NaF in drinking water at 15 mg/L alone [21]. Group III rats were orally administered taurine at a dose of 200 mg/kg using drinking water as vehicle [22]. Groups IV rats were co-administered with NaF and taurine at 100 mg/kg (TAU 1).…”

Section: Experimental Protocolmentioning

confidence: 99%

Taurine Ameliorates Renal Oxidative Damage and Thyroid Dysfunction in Rats Chronically Exposed to Fluoride

Adedara

Ojuade

Olabiyi

et al. 2016

Biol Trace Elem Res

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Excessive exposure to fluoride poses several detrimental effects to human health particularly the kidney which is a major organ involved in its elimination from the body. The influence of taurine on fluoride-induced renal toxicity was investigated in a co-exposure paradigm for 45 days using five groups of eight rats each. Group I rats received normal drinking water alone, group II rats were exposed to sodium fluoride (NaF) in drinking water at 15 mg/L alone, group III received taurine alone at a dose of 200 mg/kg group IV rats were co-administered with NaF and taurine (100 mg/kg), while group V rats were co-administered with NaF and taurine (200 mg/kg). Administration of taurine significantly reversed the fluoride-mediated decrease in absolute weight and organo-somatic index of the kidney in the exposed rats. Taurine significantly prevented fluoride-induced elevation in plasma urea and creatinine levels in the exposed rats. Moreover, taurine restored fluoride-mediated decrease in the circulatory concentrations of triiodothyronine, thyroxine, and the ratio of triiodothyronine to thyroxine. Taurine ameliorated fluoride-mediated decrease in renal antioxidant status by significantly enhancing the antioxidant enzyme activities as well as glutathione level in the exposed rats. Additionally, taurine inhibited fluoride-induced renal oxidative damage by markedly decreasing the hydrogen peroxide and malondialdehyde levels as well as improved the kidney architecture in the treated rats. Collectively, taurine protected against fluoride-induced renal toxicity via enhancement of thyroid gland function, renal antioxidant status, and histology in rats.

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Taurine protects rat testes against doxorubicin-induced oxidative stress as well as p53, Fas and caspase 12-mediated apoptosis

Cited by 125 publications

References 64 publications

Protective Effects of Rosmarinic Acid on Doxorubicin-Induced Testicular Damage

Protective Effects of Rosmarinic Acid on Doxorubicin-Induced Testicular Damage

The Effects of Taurine on Permethrininduced Cytogenetic and Oxidative Damage in Cultured Human Lymphocytes

Taurine Ameliorates Renal Oxidative Damage and Thyroid Dysfunction in Rats Chronically Exposed to Fluoride

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