Targeting Tumor Metabolism to Overcome Radioresistance

Wahl, Daniel R.; Petronek, Michael; Rashmi, Ramachandran; Floberg, John M.; Allen, Bryan G.; Schwarz, Julie K.

doi:10.1007/978-3-030-49701-9_10

Cited by 2 publications

(2 citation statements)

References 268 publications

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“…Apart from the inhibition of mitochondrial functions, other potential targets for radiosensitization in the network of tumor metabolism include for example α-KG as a rate-limiting substrate of the PHD family of enzymes [ 288 ], and a broad spectrum of enzymes involved in glycolysis and the PPP (reviewed in [ 26 , 153 , 289 ]). Overall, current mechanistic insights indeed support the role of numerous metabolic entities in the development of radioresistance, however the effects of interference with these entities as targets in the context of radiotherapy remains to be investigated.…”

Section: Radiotherapy and Tumor Hypoxiamentioning

confidence: 99%

Interfering with Tumor Hypoxia for Radiotherapy Optimization

Telarovic

Wenger

Pruschy

2021

J Exp Clin Cancer Res

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Hypoxia in solid tumors is an important predictor of treatment resistance and poor clinical outcome. The significance of hypoxia in the development of resistance to radiotherapy has been recognized for decades and the search for hypoxia-targeting, radiosensitizing agents continues. This review summarizes the main hypoxia-related processes relevant for radiotherapy on the subcellular, cellular and tissue level and discusses the significance of hypoxia in radiation oncology, especially with regard to the current shift towards hypofractionated treatment regimens. Furthermore, we discuss the strategies to interfere with hypoxia for radiotherapy optimization, and we highlight novel insights into the molecular pathways involved in hypoxia that might be utilized to increase the efficacy of radiotherapy.

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Section: Radiotherapy and Tumor Hypoxiamentioning

confidence: 99%

Interfering with Tumor Hypoxia for Radiotherapy Optimization

Telarovic

Wenger

Pruschy

2021

J Exp Clin Cancer Res

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“…Also, this molecule facilitates nanocarrier's internalization within the cancer cells [108]. MTX is helpful in many malignancies, such as leukemia, hematologic malignancies, osteosarcoma, breast and cervical cancer, and even rheumatoid arthritis [109]. Nosrati et al designed and fabricated a drug delivery system via conjugation of MTX on the surface of L-lysinecoated iron oxide magnetic nanoparticles (F-Lys-MTX NPs).…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

Applications of Iron Oxide Nanoparticles against Breast Cancer

Hosseinkazemi

Samani

O’Neill

et al. 2022

Journal of Nanomaterials

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Breast cancer is the most common cancer diagnosed in women, with an estimated 12% of women in the United States affected during their lifetime. Researchers have demonstrated that early detection, diagnosis, and treatment are pivotal to increasing survival. The advent of nanotechnology has yielded several novel advances and available modern methods within the clinic to detect and treat breast cancer. Inorganic nanoparticles are broadly utilized for cancer diagnosis and therapeutic purposes. Interestingly, these nanoparticles can also be attached to tumor-specific ligands and used to deliver chemotherapeutic or hormonal agents with high levels of tumor selectivity. Iron oxide nanoparticles are one of the most commonly used nanomaterials, which have attracted much attention to detect and treat breast cancers, owing to their superparamagnetic characteristics. Computerized tomography and magnetic resonance imaging (MRI) utilizing iron-based magnetic nanoparticles are promising approaches for the radiological detection of breast cancer. Here, we discuss the roles and recent applications of iron oxide nanoparticles in diagnosing and treating breast cancer.

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Targeting Tumor Metabolism to Overcome Radioresistance

Cited by 2 publications

References 268 publications

Interfering with Tumor Hypoxia for Radiotherapy Optimization

Interfering with Tumor Hypoxia for Radiotherapy Optimization

Applications of Iron Oxide Nanoparticles against Breast Cancer

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