Targeting PI3K/Akt/mTOR signaling pathway by polyphenols: Implication for cancer therapy

Mirza-Aghazadeh-Attari, Mohammad; Ekrami, Elyad; Mousavi-Aghdas, Seyed Ali; Mihanfar, Ainaz; Hallaj, Shahin; Yousefi, Bahman; Safa, Amin; Majidinia, Maryam

doi:10.1016/j.lfs.2020.117481

Cited by 80 publications

(55 citation statements)

References 249 publications

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“…The activation of mTOR phosphorylates the downstream P70S6K1 effector to initiate the translation process and promote the synthesis of RNA and proteins (24,25). This pathway participates in the occurrence and development of multiple tumors and angiogenesis, and is also considered as the primary pathway for cancer cell survival (26,27). Then, in vitro cell experiment indicated that the transfection with PI3K/AKT/mTOR pathway agonist IGF-1 recovered the pro-apoptotic effects of PTPRZ1 overexpression.…”

Section: Discussionmentioning

confidence: 99%

PTPRZ1 Inhibits the Cisplatin Resistance of Ovarian Cancer by Regulating PI3K/AKT/mTOR Signal Pathway

Wang

et al. 2020

Preprint

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Background: Cisplatin resistance (DDP resistance) is a major cause for poor prognosis of ovarian cancer patients. PTPRZ1 has been proven to participate in the occurrence and development of multiple tumors, including tumor resistance. This study was designed to investigate the roles of PTPRZ1 in DDP-resistant ovarian cancer cells and their possible mechanism.Methods: PTPRZ1 expression in ovarian cancer tissues and normal tissues was analyzed by GEPIA database and verified by qRT-PCR. PTPRZ1 expression in normal ovarian cancer cells and DDP-resistant ovarian cancer cells was also analyzed. Subsequently, qRT-PCR, western blot, MTT experiment and flow cytometry were used to assess the effects of PTPRZ1-PI3K/AKT/mTOR regulating axis on cisplatin resistance of ovarian cancer.Results: PTPRZ1 expression was abnormally low in ovarian cancer tissues, and notably reduced in DDP-resistant ovarian cancer cells. MTT experiment and flow cytometer indicated that overexpression of PTPRZ1 enhanced the cisplatin sensitivity of ovarian cancer cells and promoted the cell apoptosis. The results of mechanism research showed that PTPRZ1 exerted its biological effects possibly through blocking PI3K/AKT/mTOR pathway.Conclusion: PTPRZ1 suppresses the cisplatin resistance of ovarian cancer and induces the cytotoxicity by blocking PI3K/AKT/mTOR pathway.

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Section: Discussionmentioning

confidence: 99%

PTPRZ1 Inhibits the Cisplatin Resistance of Ovarian Cancer by Regulating PI3K/AKT/mTOR Signal Pathway

Wang

et al. 2020

Preprint

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“…98,99 Currently, metabolic pathways, especially aerobic glycolysis, could be modulated by PI3K/Akt signaling, which may provide evidence for clinical interventions in glioma. 100,101 Gathering evidence has confirmed the relevance of glycolysis with PI3K/Akt signaling in glioma. It has been found that the activities of glycolysis were modulated by PI3K/Akt signaling in regulating glucose uptake, lactic acid production, and nicotinamide adenine dinucleotide (NAD) level.…”

Section: Roles Of Main Signaling Pathways In Aerobic Glycolysis Pi3k/mentioning

confidence: 94%

<p>Emerging Roles and Therapeutic Interventions of Aerobic Glycolysis in Glioma</p>

Han¹,

Shi²,

Cao³

et al. 2020

OTT

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Glioma is the most common type of intracranial malignant tumor, with a great recurrence rate due to its infiltrative growth, treatment resistance, intra-and intertumoral genetic heterogeneity. Recently, accumulating studies have illustrated that activated aerobic glycolysis participated in various cellular and clinical activities of glioma, thus influencing the efficacy of radiotherapy and chemotherapy. However, the glycolytic process is too complicated and ambiguous to serve as a novel therapy for glioma. In this review, we generalized the implication of key enzymes, glucose transporters (GLUTs), signalings and transcription factors in the glycolytic process of glioma. In addition, we summarized therapeutic interventions via the above aspects and discussed promising clinical applications for glioma.

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“…The AKT/mTOR pathway regulates various cellular processes which include protein synthesis, cell proliferation, energy metabolism and autophagy. [24][25][26][27] mTOR inhibitor Rapa inhibits the expression of p-p70S6K and regulates downstream pathways. Thus, pS6K is used as a marker for mTOR1 activity.…”

Section: The Antitumor Mechanism Of Rapa Liposomes and 5-fu In Vitromentioning

confidence: 99%

Delivery of Rapamycin by Liposomes Synergistically Enhances the Chemotherapy Effect of 5-Fluorouracil on Colorectal Cancer

Chen

Zhu

Lin

et al. 2021

IJN

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Targeting PI3K/Akt/mTOR signaling pathway by polyphenols: Implication for cancer therapy

Cited by 80 publications

References 249 publications

PTPRZ1 Inhibits the Cisplatin Resistance of Ovarian Cancer by Regulating PI3K/AKT/mTOR Signal Pathway

PTPRZ1 Inhibits the Cisplatin Resistance of Ovarian Cancer by Regulating PI3K/AKT/mTOR Signal Pathway

<p>Emerging Roles and Therapeutic Interventions of Aerobic Glycolysis in Glioma</p>

Delivery of Rapamycin by Liposomes Synergistically Enhances the Chemotherapy Effect of 5-Fluorouracil on Colorectal Cancer

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