Targeting B Lymphocytes Using Protein‐Functionalized Graphene Oxide

Muzi, Laura; Seifert, Cécile; Soltani, R.; Ménard‐Moyon, Cécilia; Dumortier, Hélène; Bianco, Alberto

doi:10.1002/anbr.202100060

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…Recently, Muzi functionalized GO with hen egg lysozyme (HEL) through a simple non-covalent conjugation method and used the nanocarrier for the selective targeting of B lymphocytes in autoimmune diseases. It was suggested that the same process could be used for other proteins or peptides capable of targeting certain new B cells ( Muzi et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Graphene-based nanomaterials for stimuli-sensitive controlled delivery of therapeutic molecules

Khakpour

Salehi²,

Naghib³

et al. 2023

Front. Bioeng. Biotechnol.

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Stimuli-responsive drug delivery has attracted tremendous attention in the past decades. It provides a spatial- and temporal-controlled release in response to different triggers, thus enabling highly efficient drug delivery and minimizing drug side effects. Graphene-based nanomaterials have been broadly explored, and they show great potential in smart drug delivery due to their stimuli-responsive behavior and high loading capacity for an extended range of drug molecules. These characteristics are a result of high surface area, mechanical stability and chemical stability, and excellent optical, electrical, and thermal properties. Their great and infinite functionalization potential also allows them to be integrated into several types of polymers, macromolecules, or other nanoparticles, leading to the fabrication of novel nanocarriers with enhanced biocompatibility and trigger-sensitive properties. Thus, numerous studies have been dedicated to graphene modification and functionalization. In the current review, we introduce graphene derivatives and different graphene-based nanomaterials utilized in drug delivery and discuss the most important advances in their functionalization and modification. Also, their potential and progress in an intelligent drug release in response to different types of stimuli either endogenous (pH, redox conditions, and reactive oxygen species (ROS)) or exogenous (temperature, near-infrared (NIR) radiation, and electric field) will be debated.

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Section: Introductionmentioning

confidence: 99%

Graphene-based nanomaterials for stimuli-sensitive controlled delivery of therapeutic molecules

Khakpour

Salehi²,

Naghib³

et al. 2023

Front. Bioeng. Biotechnol.

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“…GO has benefited manyfold in sensing applications: firstly, GO coating attracts reproducibly and homogeneously a large fraction of the molecules in the proximity of the hot spots thanks to the combination of a hydrophobic structure with oxygenated surface functional groups. The GO-lysozyme interaction is so strong that recently GO-lysozyme bio-conjugates have been proposed as nanocarriers for the targeted therapy of B-cell-mediated autoimmune diseases [44]. Secondly, the GO veil can be readily prepared by direct physisorption on the nanoparticles' assembly with precise control of surface coverage and thickness as opposed to complex vapor deposition techniques often used for graphene.…”

Section: Introductionmentioning

confidence: 99%

Graphene Oxide/Silver Nanoparticles Platforms for the Detection and Discrimination of Native and Fibrillar Lysozyme: A Combined QCM and SERS Approach

et al. 2022

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We propose a sensing platform based on graphene oxide/silver nanoparticles arrays (GO/AgNPs) for the detection and discrimination of the native and toxic fibrillar forms of an amyloid-prone protein, lysozyme, by means of a combination of Quartz Crystal Microbalance (QCM) and Surface Enhanced Raman Scattering (SERS) measurements. The GO/AgNPs layer system was obtained by Langmuir-Blodgett assembly of the silver nanoparticles followed by controlled adsorption of GO sheets on the AgNPs array. The adsorption of native and fibrillar lysozyme was followed by means of QCM, the measurements provided the kinetics and the mechanism of adsorption as a function of protein concentration as well as the mass and thickness of the adsorbed protein on both nanoplatforms. The morphology of the protein layer was characterized by Confocal Laser Scanning Microscopy experiments on Thioflavine T-stained samples. SERS experiments performed on arrays of bare AgNPs and of GO coated AgNP after native, or fibrillar, lysozyme adsorption allowed for the discrimination of the native form and toxic fibrillar structure of lysozyme. Results from combined QCM/SERS studies indicate a general construction paradigm for an efficient sensing platform with high selectivity and low detection limit for native and amyloid lysozyme.

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Development of Graphene‐Based Materials in Bone Tissue Engineaering

et al. 2021

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Currently, general treatments of criticalsized bone defects include autografts, allografts, and the use of bone regeneration biomaterials. [1] Autograft is the gold standard approach due to its satisfying osteogenicity. But it also faces drawbacks such as an invasive surgical operation for bone harvest and scarcity of available donor sites. [2] Allograft is accompanied by the risk of disease transmission and immunological rejection. [2] Therefore, significant efforts have been devoted to finding alternative approaches for bone regeneration. Bone tissue engineering (BTE) provides a promising alternative strategy to realize higher-level restoration of bone defects. BTE exploits the elaborate combination of scaffolds, seeding cells, and biological factors to form a functional substitute or assist in situ regeneration. In most BTE research, stem cells are implanted into defective bone sites with the support of a biomaterial-based scaffold and are supposed to proliferate and differentiate into osteoblasts to promote bone regeneration. However, the performances of many current BTE systems could not meet the therapeutic expectation due to problems such as insufficient osteogenic differentiation and limited vascularization. [3][4][5] Many studies tried to improve the performance of BTE via enhancing the properties of the biomaterial-based scaffold. [6] In addition to traditional macroor microscale forms of metals, ceramics, and polymers, their nanoscale counterparts have been extensively explored for BTE due to their unique properties. [7][8][9][10] Ever since Andre Geim and Konstantin Novoselov [11] discovered a simple and feasible method for graphene isolation, graphene family materials (GFMs) have attracted great interest in regenerative medicine and tissue engineering. In BTE, bGBMs show promising potentials such as mechanical strength, high specific surface, and adsorption ability. [12][13][14][15][16][17] According to the composition, bGBMs could be categorized into GFMs and GFMs-containing composite materials (GCMs). GFMs refer to graphene and its derivatives, containing 0D graphene quantum dots (GQDs), 2D graphene (GR), graphene oxide (GO), and reduced graphene oxide (rGO), 3D graphite, etc. Among them, GQDs, GR, GO, and rGO could be obtained by chemical approaches using graphite as the starting material. GCMs are composite materials consisting of GFMs and other materials such Bone regeneration-related graphene-based materials (bGBMs) are increasingly attracting attention in tissue engineering due to their special physical and chemical properties. The purpose of this review is to quantitatively analyze mass academic literature in the field of bGBMs through scientometrics software CiteSpace, to demonstrate the rules and trends of bGBMs, thus to analyze and summarize the mechanisms behind the rules, and to provide clues for future research. First, the research status, hotspots, and frontiers of bGBMs are analyzed in an intuitively and vividly visualized way. Next, the extracted important subjects such as fabricatio...

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Targeting B Lymphocytes Using Protein‐Functionalized Graphene Oxide

Cited by 3 publications

References 30 publications

Graphene-based nanomaterials for stimuli-sensitive controlled delivery of therapeutic molecules

Graphene-based nanomaterials for stimuli-sensitive controlled delivery of therapeutic molecules

Graphene Oxide/Silver Nanoparticles Platforms for the Detection and Discrimination of Native and Fibrillar Lysozyme: A Combined QCM and SERS Approach

Development of Graphene‐Based Materials in Bone Tissue Engineaering

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