Graphene-based nanomaterials for stimuli-sensitive controlled delivery of therapeutic molecules

Khakpour, Elnaz; Salehi, Saba; Naghib, Seyed Morteza; Ghorbanzadeh, Sadegh; Zhang, Wei

doi:10.3389/fbioe.2023.1129768

Cited by 12 publications

(5 citation statements)

References 76 publications

(101 reference statements)

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“… 47 Furthermore, the presence of π-orbitals throughout the sp2-hybridized GQDs lattice improves drug delivery. 48,49 Therefore, GQDs are potentially promising materials for biomedical applications.…”

Section: Graphene Quantum Dots (Gqds)mentioning

confidence: 99%

Photothermal therapy using graphene quantum dots

Dar,

Tabish,

Thorat

et al. 2023

APL Bioengineering

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The rapid development of powerful anti-oncology medicines have been possible because of advances in nanomedicine. Photothermal therapy (PTT) is a type of treatment wherein nanomaterials absorb the laser energy and convert it into localized heat, thereby causing apoptosis and tumor eradication. PTT is more precise, less hazardous, and easy-to-control in comparison to other interventions such as chemotherapy, photodynamic therapy, and radiation therapy. Over the past decade, various nanomaterials for PTT applications have been reviewed; however, a comprehensive study of graphene quantum dots (GQDs) has been scantly reported. GQDs have received huge attention in healthcare technologies owing to their various excellent properties, such as high water solubility, chemical stability, good biocompatibility, and low toxicity. Motivated by the fascinating scientific discoveries and promising contributions of GQDs to the field of biomedicine, we present a comprehensive overview of recent progress in GQDs for PTT. This review summarizes the properties and synthesis strategies of GQDs including top-down and bottom-up approaches followed by their applications in PTT (alone and in combination with other treatment modalities such as chemotherapy, photodynamic therapy, immunotherapy, and radiotherapy). Furthermore, we also focus on the systematic study of in vitro and in vivo toxicities of GQDs triggered by PTT. Moreover, an overview of PTT along with the synergetic application used with GQDs for tumor eradication are discussed in detail. Finally, directions, possibilities, and limitations are described to encourage more research, which will lead to new treatments and better health care and bring people closer to the peak of human well-being.

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Section: Graphene Quantum Dots (Gqds)mentioning

confidence: 99%

Photothermal therapy using graphene quantum dots

Dar,

Tabish,

Thorat

et al. 2023

APL Bioengineering

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“…The distinctive functional groups and distinctive hexagonal carbon structural composition contribute to the diverse surface chemistry of GO. Covalent and non-covalent bonds can be created because of this chemistry [110]. The loading technique for pharmaceuticals with NGO may be divided into three main categories: non-covalent bonds, covalent bonds, and mixtures of these two methods (Figure 6).…”

Section: Drug-loading Approachesmentioning

confidence: 99%

Graphene Oxide Nanostructures as Nanoplatforms for Delivering Natural Therapeutic Agents: Applications in Cancer Treatment, Bacterial Infections, and Bone Regeneration Medicine

AbouAitah,

Sabbagh,

Kim

2023

Nanomaterials

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Graphene, fullerenes, diamond, carbon nanotubes, and carbon dots are just a few of the carbon-based nanomaterials that have gained enormous popularity in a variety of scientific disciplines and industrial uses. As a two-dimensional material in the creation of therapeutic delivery systems for many illnesses, nanosized graphene oxide (NGO) is now garnering a large amount of attention among these materials. In addition to other benefits, NGO functions as a drug nanocarrier with remarkable biocompatibility, high pharmaceutical loading capacity, controlled drug release capability, biological imaging efficiency, multifunctional nanoplatform properties, and the power to increase the therapeutic efficacy of loaded agents. Thus, NGO is a perfect nanoplatform for the development of drug delivery systems (DDSs) to both detect and treat a variety of ailments. This review article’s main focus is on investigating surface functionality, drug-loading methods, and drug release patterns designed particularly for smart delivery systems. The paper also examines the relevance of using NGOs to build DDSs and considers prospective uses in the treatment of diseases including cancer, infection by bacteria, and bone regeneration medicine. These factors cover the use of naturally occurring medicinal substances produced from plant-based sources.

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“…Carbon-based nanomaterials have great potential in lymphatic drug delivery due to their large internal space for high drug loading and the ability to provide personalized active functional groups through chemical covalent modification [ 84 ]. Currently, graphene nanoparticles and carbon nanotubes are widely used as carbon-based nanodelivery materials.…”

Section: Lymphatic Diagnosis and Treatment Nanomedicinesmentioning

confidence: 99%

Advances in nanomedicines for lymphatic imaging and therapy

He,

Tang,

Zheng

et al. 2023

J Nanobiotechnol

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Lymph nodes play a pivotal role in tumor progression as key components of the lymphatic system. However, the unique physiological structure of lymph nodes has traditionally constrained the drug delivery efficiency. Excitingly, nanomedicines have shown tremendous advantages in lymph node-specific delivery, enabling distinct recognition and diagnosis of lymph nodes, and hence laying the foundation for efficient tumor therapies. In this review, we comprehensively discuss the key factors affecting the specific enrichment of nanomedicines in lymph nodes, and systematically summarize nanomedicines for precise lymph node drug delivery and therapeutic application, including the lymphatic diagnosis and treatment nanodrugs and lymph node specific imaging and identification system. Notably, we delve into the critical challenges and considerations currently facing lymphatic nanomedicines, and futher propose effective strategies to address these issues. This review encapsulates recent findings, clinical applications, and future prospects for designing effective nanocarriers for lymphatic system targeting, with potential implications for improving cancer treatment strategies.

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Graphene-based nanomaterials for stimuli-sensitive controlled delivery of therapeutic molecules

Cited by 12 publications

References 76 publications

Photothermal therapy using graphene quantum dots

Photothermal therapy using graphene quantum dots

Graphene Oxide Nanostructures as Nanoplatforms for Delivering Natural Therapeutic Agents: Applications in Cancer Treatment, Bacterial Infections, and Bone Regeneration Medicine

Advances in nanomedicines for lymphatic imaging and therapy

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