Targeting arachidonic acid pathway by natural products for cancer prevention and therapy

Yarla, Nagendra Sastry; Bishayee, Anupam; Sethi, Gautam; Reddanna, Pallu; Kalle, Arunasree M.; Dhananjaya, Bhadrapura Lakkappa; Dowluru, Kaladhar Svgk; Chintala, Ramakrishna; Duddukuri, Govinda Rao

doi:10.1016/j.semcancer.2016.02.001

Cited by 285 publications

(180 citation statements)

References 491 publications

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“…Chlorogenic acid, which is a compound in foods, was observed to safeguard hepatic damage and exhibits an anti‐inflammatory effect (Jaeschke, ). The enzymes involved in the arachidonic acid mechanism are reported to have preventive activities against the disease related to a neural complication, respiratory disorders, hepatic injury and gastric lesions (Yarla et al ., ).…”

Section: Natural Productsmentioning

confidence: 97%

Natural remedies for non‐steroidal anti‐inflammatory drug‐induced toxicity

Simon

Sabina

2016

J of Applied Toxicology

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The liver is an important organ of the body, which has a vital role in metabolic functions. The non-steroidal anti-inflammatory drug (NSAID), diclofenac causes hepato-renal toxicity and gastric ulcers. NSAIDs are noted to be an agent for the toxicity of body organs. This review has elaborated various scientific perspectives of the toxicity caused by diclofenac and its mechanistic action in affecting the vital organ. This review suggests natural products are better remedies than current clinical drugs against the toxicity caused by NSAIDs. Natural products are known for their minimal side effects, low cost and availability. On the other hand, synthetic drugs pose the danger of adverse effects if used frequently or over a long period. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Natural Productsmentioning

confidence: 97%

Natural remedies for non‐steroidal anti‐inflammatory drug‐induced toxicity

Simon

Sabina

2016

J of Applied Toxicology

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“…Mother Nature is the origin of 70% of the pharmaceuticals, however, there is a need to explore this vast reserve further for identification of various novel phytochemicals and chemotherapeutic agents for better management of this disease [19,20,21,22,23,24,25,26,27,28,29,30,31,32]. These natural products display inherent anti-cancer properties which emanate from a range of phytochemicals such as alkaloids, diterpenoids, flavonoids, polyphenolic compounds and sesquiterpenes obtained from various medicinal plants, fruits and vegetables [23,27,33,34,35,36,37].…”

Section: Introductionmentioning

confidence: 99%

Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer

Ranaware¹,

Banik

Deshpande³

et al. 2018

IJMS

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134

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The past few decades have witnessed widespread research to challenge carcinogenesis; however, it remains one of the most important health concerns with the worst prognosis and diagnosis. Increasing lines of evidence clearly show that the rate of cancer incidence will increase in future and will create global havoc, designating it as an epidemic. Conventional chemotherapeutics and treatment with synthetic disciplines are often associated with adverse side effects and development of chemoresistance. Thus, discovering novel economic and patient friendly drugs that are safe and efficacious is warranted. Several natural compounds have proved their potential against this dreadful disease so far. Magnolol is a hydroxylated biphenyl isolated from the root and stem bark of Magnolia tree. Magnolol can efficiently prevent or inhibit the growth of various cancers originating from different organs such as brain, breast, cervical, colon, liver, lung, prostate, skin, etc. Considering these perspectives, the current review primarily focuses on the fascinating role of magnolol against various types of cancers, and the source and chemistry of magnolol and the molecular mechanism underlying the targets of magnolol are discussed. This review proposes magnolol as a suitable candidate that can be appropriately designed and established into a potent anti-cancer drug.

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“…Apigenin is a flavonoid compound distributed extensively in vegetables and fruits grown in the temperate and tropical zones. Its content is particularly high in celery (2). Its content is also high in some medicinal plants such as Semen Plantaginis and Chinese Star Jasmine Stem.…”

Section: Introductionmentioning

confidence: 99%

Apigenin in the regulation of cholesterol metabolism and protection of blood vessels

Zhang

Song

et al. 2017

Experimental and Therapeutic Medicine

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Hyperlipidemia is a major independent risk factor for atherosclerosis. Seeking natural compounds in medicinal plants capable of reducing blood fat and studying their mechanisms of action has been the focus of research in recent years. The aim of the present study was to analyze the mechanisms of apigenin in regulating cholesterol metabolism and protecting blood vessels, and to provide a theoretical basis for the clinical application of apigenin. The mouse model of hyperlipidemia was established to verify the efficacy of apigenin in improving hyperlipidemia and to observe the mechanism of action of apigenin in reducing cholesterol content. In vitro cell experiments were conducted to evaluate the role of apigenin in mediating reverse cholesterol transport. Additionally, H2O2-injured human umbilical venous endothelial cells (EA.hy926 cells) were used for further study on the roles of apigenin in resisting oxidization and protecting vascular endothelial cells. Apigenin significantly regulated blood fat, reduced animal weight, and reduced total cholesterol (P=0.024), triglyceride (P=0.031) and low-density lipoprotein cholesterol (P=0.014) in the serum of the high-fat diet mice. Apigenin improved the blood lipid metabolism of the hyper-lipidemia model mice. Body weight and serum cholesterol content increased abnormally (P=0.003) as a consequence of high-fat diet. Apigenin increased the activity of superoxide dismutase in EA.hy926 cells (P=0.043) and increased the amount of nitric oxide secreted by the cells (P=0.038). Apigenin also inhibited the proliferation of vascular smooth muscle cells in a dose-dependent manner (P=0.036). In conclusion, apigenin can regulate cholesterol metabolism in vivo and plays a role in reducing the level of blood fat by promoting cholesterol absorption and conversion, and accelerating reverse cholesterol transport. Apigenin also has a role in resisting oxidization and protecting blood vessels.

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Targeting arachidonic acid pathway by natural products for cancer prevention and therapy

Cited by 285 publications

References 491 publications

Natural remedies for non‐steroidal anti‐inflammatory drug‐induced toxicity

Natural remedies for non‐steroidal anti‐inflammatory drug‐induced toxicity

Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer

Apigenin in the regulation of cholesterol metabolism and protection of blood vessels

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